Effect of three polyether ionophores on pharmacokinetics of florfenicol in male broilers

Wang, G.-Y.; Tu, Piao-Han; Chen, X.; Guo, Yong-gang; Jiang, Shanxiang

doi:10.1111/jvp.12020

Cited by 24 publications

(26 citation statements)

References 40 publications

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“…Florfenicol pharmacokinetics in broiler chickens have been investigated (Afifi & El-Sooud, 1997;Gharaibeh et al, 2010;Shen, Hu, Wu, & Coats, 2003;Shen, Wu, Hu, & Jiang, 2002) and ducks (El-Banna, 1998). Initial studies were recorded on the pharmacokinetic DDIs of florfenicol and anthelmintics as ivermectin and rafoxanide, and albendazole in goats (Atef, El-Gendi, Amer, & El-Aty, 2010), or polyether ionophore antibiotics group as monensin, salinomycin and maduramycin in broilers (Wang et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Effects of the dietary inclusion of a probiotic or prebiotic on florfenicol pharmacokinetic profile in broiler chicken

Elgeddawy¹,

Shaheen

El‐Sayed

et al. 2020

Animal Physiology Nutrition

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We evaluated the effect of prebiotic or probiotic as feed additives on florfenicol kinetic in broilers feed. Unsexed two hundred, thirty‐five‐day‐old broiler chickens, were put in four equal groups (n = 50). The first group was administrated florfenicol intravenous at 30 mg/kg body weight (BW) only once dosage without pre‐ or probiotic administration to determine the bioavailability. While, the second group was administrated florfenicol (intracrop routes; a dosage of 30 mg/kg BW for five progressive days) without pre‐ or probiotic co‐administration. The third and the fourth groups were administrated the same dose of florfenicol (intracrop route) for five successive days, followed by 10 days of prebiotic or probiotic treatment respectively. The plasma florfenicol % was identified by high‐pressure liquid chromatography (HPLC) after the first florfenicol administration (intravenous or intracrop routes) in all groups. Then, the residual levels of florfenicol were determined in liver, kidney and muscle tissues from the second, third and fourth groups which were exposed to florfenicol orally. Our results demonstrated that broilers pre‐treated with prebiotic or probiotic significantly increased Cmax, AUC0–t, AUC0–inf as well as AUMC values, while significant drop was recorded in V/F and CL/F. Prebiotic or probiotic influenced the cumulative effect of florfenicol in liver and kidney tissues of treated birds.

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Section: Introductionmentioning

confidence: 99%

Effects of the dietary inclusion of a probiotic or prebiotic on florfenicol pharmacokinetic profile in broiler chicken

Elgeddawy¹,

Shaheen

El‐Sayed

et al. 2020

Animal Physiology Nutrition

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“…The pharmacokinetics of FFC have been extensively studied in many species of animals [ 25 ], especially in rabbits [ 1 , 18 , 23 ]. The pharmacokinetic DDIs of FFC and other drugs such as anthelmintics (ivermectin, albendazole, and rafoxanide) in goats [ 3 ] or polyether ionophore antibiotics (salinomycin, monensin, and maduramycin) in broiler chickens [ 32 ] have also been investigated.…”

Section: Introductionmentioning

confidence: 99%

Influence of three coccidiostats on the pharmacokinetics of florfenicol in rabbits

et al. 2015

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In-feed Medication has been used for a long time to prevent coccidiosis, a worldwide protozoal disease in rabbits. Florfenicol (FFC) has been widely used in veterinary clinics for bacterial diseases treatment. Therefore, the use of combinations of coccidiostats with FFC in rabbits is common. In the present study, we aimed to evaluate the effect of three coccidiostats, sulfaquinoxaline (SUL), robenidine (ROB), and toltrazuril (TOL), as feed additives on the pharmacokinetic profile of FFC in rabbits. The disposition kinetics of FFC in rabbits were investigated after a single intravenous injection (25 mg/kg) in rabbits fed anticoccidial-free diets or feeds containing SUL (250 ppm), ROB (66 ppm), or TOL (2 ppm), respectively, for 20 days. Plasma FFC concentrations were determined by the high performance liquid chromatography (HPLC) method. The pharmacokinetic parameters of FFC were analyzed using a non-compartmental analysis based on the statistical moment theory. The results demonstrated that ROB feeding resulted in an obvious decrease in plasma FFC level as compared with anticoccidial-free feeding. The terminal elimination half-life (t1/2z), area under the concentration–time curve (AUC), area under the first moment curve (AUMC), and mean residence time (MRT) significantly decreased, whereas the elimination rate constant (λz) and total body clearance (CLz) obviously increased in rabbits pretreated with ROB. However, we did not find that SUL or TOL feeding had any effect on the pharmacokinetic profile of FFC. Our findings suggested that more attention should be paid to the use of FFC in rabbits supplemented with ROB.

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“…Florfenicol is a synthetic broad-spectrum antibiotic with activities like that of chloramphenicol; the drug is widely used to control bacterial infection in veterinary practice [27,30,32]. Florfenicol has low toxicity and better antibacterial activity than does chloramphenicol or thiamphenicol [3,12,25].…”

Section: Introductionmentioning

confidence: 99%

“…Florfenicol has low toxicity and better antibacterial activity than does chloramphenicol or thiamphenicol [3,12,25]. The pharmacokinetics of florfenicol has been documented in many animal species [1,2,6,22,29,32]. A few studies have also reported on the possible metabolic pathways and mechanisms of florfenicol in vivo.…”

Section: Introductionmentioning

confidence: 99%

Effects of anemoside B4 on pharmacokinetics of florfenicol and mRNA expression of CXR, MDR1, CYP3A37 and UGT1E in broilers

Yang

et al. 2019

The Journal of Veterinary Medical Science

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pulsatillae radix, a traditional Chinese medicine (TCM), is often used in combination with florfenicol for treatment of intestinal infection in Chinese veterinary clinics. Anemoside B4 (AB4) is the major effective saponin in Pulsatillae radix. This study aimed to investigate whether the pharmacokinetics of florfenicol in broilers was affected by the combination of AB4. In this study, broilers were given AB4 (50 mg/kg BW), or 0.9% sodium chloride solution by oral administration for 7 days. They were then fed florfenicol orally (30 mg/kg BW) on the eighth day. The results showed that the AUC (0-∞) , MRT (0-∞) , t 1/2z and C max of florfenicol were significantly decreased, and the Vz/F and CLz/F were significantly increased by AB4; the mRNA expression levels of CXR, CYP3A37 and MDR1 (except CXR and CYP3A37 in the liver) were up-regulated by AB4. In conclusion, AB4 altered the pharmacokinetics of florfenicol, resulting in lower plasma concentrations of florfenicol, this was probably related to the mRNA expression of CXR, CYP3A37 and MDR1 in the jejunum and liver (except CXR and CYP3A37) increased by AB4. The implications of these findings on the effect of traditional Chinese medicine containing AB4 on the effectiveness of florfenicol in veterinary practice deserve study.

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Effect of three polyether ionophores on pharmacokinetics of florfenicol in male broilers

Cited by 24 publications

References 40 publications

Effects of the dietary inclusion of a probiotic or prebiotic on florfenicol pharmacokinetic profile in broiler chicken

Effects of the dietary inclusion of a probiotic or prebiotic on florfenicol pharmacokinetic profile in broiler chicken

Influence of three coccidiostats on the pharmacokinetics of florfenicol in rabbits

Effects of anemoside B4 on pharmacokinetics of florfenicol and mRNA expression of CXR, MDR1, CYP3A37 and UGT1E in broilers

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