Effects of the dietary inclusion of a probiotic or prebiotic on florfenicol pharmacokinetic profile in broiler chicken

Abstract

We evaluated the effect of prebiotic or probiotic as feed additives on florfenicol kinetic in broilers feed. Unsexed two hundred, thirty‐five‐day‐old broiler chickens, were put in four equal groups (n = 50). The first group was administrated florfenicol intravenous at 30 mg/kg body weight (BW) only once dosage without pre‐ or probiotic administration to determine the bioavailability. While, the second group was administrated florfenicol (intracrop routes; a dosage of 30 mg/kg BW for five progressive days) without pre‐ or probiotic co‐administration. The third and the fourth groups were administrated the same dose of florfenicol (intracrop route) for five successive days, followed by 10 days of prebiotic or probiotic treatment respectively. The plasma florfenicol % was identified by high‐pressure liquid chromatography (HPLC) after the first florfenicol administration (intravenous or intracrop routes) in all groups. Then, the residual levels of florfenicol were determined in liver, kidney and muscle tissues from the second, third and fourth groups which were exposed to florfenicol orally. Our results demonstrated that broilers pre‐treated with prebiotic or probiotic significantly increased Cmax, AUC0–t, AUC0–inf as well as AUMC values, while significant drop was recorded in V/F and CL/F. Prebiotic or probiotic influenced the cumulative effect of florfenicol in liver and kidney tissues of treated birds.

Dietary effect of probiotics and prebiotics on broiler performance, carcass, and immunity

“…Probiotics and prebiotics were supplemented with poultry diet to prevent diseases ( Elgeddawy et al., 2020 ). The use of probiotics and prebiotics in poultry feed can improve the immune status.…”

Probiotics in poultry feed: A comprehensive review

“…Feed additives are generally considered materials used to enhance the effectiveness of nutrients and exert their effects on improving poultry performance (Ashour et al., 2020; Farag & Alagawany, 2019; Saeed, Alagawany, et al., 2019). There are a number of feed additives used in poultry feed, such as antibiotics, probiotics, oligosaccharides, enzymes and organic acids (Bin‐Jumah et al., 2020; Elgeddawy et al., 2020; Hussein et al., 2020; Windisch et al., 2008). They are included in the diet of poultry and animals for promoting growth through their potential effect in increasing feed intake (FI; Demir et al, 2003; Mahrose et al., 2019; Wang et al., 2019; Yatoo et al., 2017).…”

Nutritional significance of amino acids, vitamins and minerals as nutraceuticals in poultry production and health – a comprehensive review

“…They include nutrients and non-nutrients, like amino acids, minerals, vitamins, fatty acids, enzymes, prebiotics, probiotics, synbiotics, pigments, medicinal herbs, herbal extracts, antioxidants, organic acids, flavouring agents, etc. (Narahari 2014;Alagawany et al 2018a;Elgeddawy et al 2020). Nutraceuticals have been in focus in poultry science quite recently due to the nutritional and healthier properties of feed ingredients and the adverse effects of chemical pharmaceuticals like antibiotic resistance and drug residues (Elnesr et al 2019a(Elnesr et al , 2020.…”