Effect of the treatment of root surface-adhered necrotic periodontal ligament with propolis or fluoride in delayed rat tooth replantation

Abstract

Under the tested conditions, the application of fluoride or propolis on root surface-adhered necrotic periodontal ligament did not favor the healing process in delayed tooth replantation.

Anti‐inflammatory and anti‐resorptive efficacy of adrenergic blockers on late replanted rat incisors

“…Rats are a commonly used animal model for reproducing tooth avulsion and replantation, and a 30‐day experimental time that was chosen to evaluate the in vivo effects of the tested medications is sufficient to observe the inflammatory and repair processes . The findings of the present study suggest that the application of adrenergic blockers to the root surface may influence the process of the periodontal destruction of replanted teeth by reducing osteoclastogenesis.…”

“…Osteoclast recruitment is under the control of a system of receptors within the tumor necrosis factor (TNF) superfamily, including osteoprotegerin (OPG) and receptor activator of nuclear factor kappa‐B ligand (RANKL), which are both expressed on the surfaces of osteoblasts . Several treatment strategies have already been studied with the aim of preventing or delaying osteoclast‐mediated root resorption after replantation, such as the use of fluoride, zoledronic acid, acetazolamide, local or systemic antibiotics, Ledermix, indomethacin, bisphosphonates, and laser therapy . Although some drugs may make the root surface more resistant to resorption and slow down resorptive processes, to date, none have been able to completely inhibit these complications.…”

Influência do meio de conservação e efeito do tratamento de superfície na anquilose e na reabsorção de tecidos mineralizados após o reimplante de dentes avulsionados

“…Nesse sentido, o tratamento das superfícies radiculares tem sido amplamente investigado no intuito de favorecer o reparo do ligamento periodontal e aumentar as chances de sucesso após o reimplante Lam et al, 2004;Panzarini et al, 2005;Poi et al, 2007;Gulinelli et al, 2008;Loo et al, 2008;Panzarini et al, 2014a;Zanetta-Barbosa et al, 2014;Yoo et al, 2015), visando principalmente um prognóstico mais favorável para os dentes mantidos fora do alvéolo ou em meio inadequado. Para tanto, há uma vasta relação de substâncias na literatura que hipoteticamente poderiam ser utilizadas para conter essas complicações decorrentes do reimplante, tais como, a formalina e o álcool (Butcher, Vidair;1955), o ácido cítrico (Polson e Proye, 1982;Klinge et al,1984), os fluoretos (Shulman et al, 1973;Gulinelli et al, 2008;Panzarini et al, 2014a), a enzima hialuronidase associada ao ácido clorídrico (Nevins et al, 1980), os antibióticos locais e sistêmicos (Sae-Lim et al, 1998;Bryson et al, 2003;de Souza Gomes et al, 2015), os antiinflamatórios (Kum et al, 2003;Zanetta-Barbosa et al, 2014), a solução de hipoclorito de sódio (Lindskog et al, 1985), as proteínas derivadas da matriz do esmalte (Iqbal e Bamass, 2001; Wiegand e Attin, 2008;Baltacioglu et al, 2011;Barbizan et al, 2015), a acetazolamida (Mori et al, 2009 e os bisfosfonados (Thong et al, 2009;Komatsu et al, 2013;Yoo et al, 2015). No entanto, na maioria dos casos o tratamento não inibiu a ocorrência de reabsorção radicular externa Trope, 2002).…”