Effect of the roselle (<i>Hibiscus sabdariffa</i> L.) calyces drink on the physiological parameters of healthy adult subjects

Diantini, Ajeng; Rahmat, Syamsul; Alpiani, Annisa; Sumiwi, Sri Adi; Lubis, Leonardo; Levita, Jutti

doi:10.3892/br.2021.1465

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…Numerous observational studies indicated that polyphenol-rich foods were strongly associated with a lower incidence of cardiovascular diseases, metabolic syndrome, and diabetes [27][28][29]. Consistency with knowledge that Passion fruit and roselle calyces have been well-documented to improve serum HDL-C and reduce LDL-C levels [30][31][32]. This might be associated with the presence of quercetin and gallic acid [33][34][35] in RP jelly drink consumption.…”

Section: Discussionmentioning

confidence: 92%

Antidyslipidemic, Antioxidant, and Anti-inflammatory Effects of Jelly Drink Containing Polyphenol-Rich Roselle Calyces Extract and Passion Fruit Juice with Pulp in Adults with Dyslipidemia: A Randomized, Double-Blind, Placebo-Controlled Trial

Khongrum

Yingthongchai

Boonyapranai

et al. 2022

Oxidative Medicine and Cellular Longevity

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Oxidative stress and inflammation play key roles in the pathophysiology in the pathophysiology of dyslipidemia, which are positive risks that increase atherosclerosis leading to important healthcare problems. Therefore, we aimed to study the antioxidant, anti-inflammatory, and lipid-lowering effects of jelly drink containing polyphenol-rich roselle calyces extract and passion fruit juice with pulp concentrate (RP jelly drink) in comparison to a placebo jelly drink for 8 weeks. Forty-three adults with dyslipidemia were randomly assigned into two groups: the RP jelly drink group and the placebo group. Glucose, total cholesterol (TC) triglyceride (TG), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), oxidative stress biomarkers, inflammatory parameters, and monocyte chemotactic protein-1 (MCP-1) were measured with fasting blood samples at baseline, 4 weeks and 8 weeks of intervention. Results showed a significant decrease in LDL-C and TG, respectively, after 8 weeks of RP jelly drink consumption (LDL-C: 107.63 ± 22.98 m g / d L ; TG: 109.79 ± 38.83 m g / d L ) compared to baseline measurements (LDL-C: 128.43 ± 32.74 m g / d L ; TG: 132.33 ± 75.11 m g / d L ). These may be possible due to reduced inflammation and improvements in oxidative stress, as demonstrated by the reduction of tumor necrosis factor- (TNF-) α and malondialdehyde (MDA), and the enhancement of glutathione (GSH) after consuming the RP jelly drink for 8 weeks. However, no significant differences of treatment on glucose, total cholesterol, MCP-1, interleukin-6, and interleukin-10 were observed. In conclusion, daily consumption of RP jelly drink for 8 weeks resulted in significant improvement in lipid profiles in subjects with dyslipidemia. However, more research is needed to assess its nutritional and functional potential.

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Section: Discussionmentioning

confidence: 92%

Antidyslipidemic, Antioxidant, and Anti-inflammatory Effects of Jelly Drink Containing Polyphenol-Rich Roselle Calyces Extract and Passion Fruit Juice with Pulp in Adults with Dyslipidemia: A Randomized, Double-Blind, Placebo-Controlled Trial

Khongrum

Yingthongchai

Boonyapranai

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…Furthermore, the study demonstrated an adverse impact on LDL cholesterol levels, which exhibited an increase, and a favorable effect on triglyceride levels, which were lower at the 30-day mark compared to the baseline. It is important to note, however, that these changes did not achieve statistical significance [44]. Another study, as reported by Mozaffari-Khosravi et al, demonstrated that patients who ingested 240 mL of tea infused with a 2 g sachet of Roselle twice daily, for a duration of one month, experienced a significant elevation in HDL levels.…”

Section: Metabolic Health Blood Glucose and Lipid Profilementioning

confidence: 89%

Exploring the Health Benefits and Therapeutic Potential of Roselle (Hibiscus sabdariffa) in Human Studies: A Comprehensive Review

Almajid,

Bazroon,

AlAhmed

et al. 2023

Cureus

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Hibiscus sabdariffa (HS), commonly known as Roselle, has a rich history of traditional uses and is recognized for its diverse pharmacological properties, including antihypertensive, anti-inflammatory, antimicrobial, and more. This comprehensive review synthesizes the existing literature on the health benefits associated with the consumption of HS or its ingredients. Key areas of focus include metabolic health, blood sugar, and lipid regulation, wherein studies have reported varying effects on parameters such as fasting blood glucose, insulin sensitivity, and lipid profiles. Furthermore, Roselle exhibits anti-inflammatory properties, as evidenced by its impact on inflammatory markers such as MCP-1 and TNF-α. Additionally, HS extracts have shown notable antibacterial efficacy against various strains, with a potential role in urinary tract infection management. Studies also suggest potential benefits for renal function, with improvements in markers such as blood urea nitrogen and creatinine levels. In this article, we aim to review the existing literature on the health benefits of HS.

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Physiological Effects and Human Health Benefits of Hibiscus sabdariffa: A Review of Clinical Trials

et al. 2022

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Hibiscus sabdariffa Linn. Malvaceae (HS) is characterized by its edible calyxes. The HS calyxes are widely used for cosmetic, food, and medicinal applications. According to ethnobotanical evidence, decoction, infusion, or maceration extracts from HS calyxes have been used in folk medicine to treat many ailments. Moreover, several in vitro and in vivo studies have demonstrated the pharmacological properties and potential human health benefits of HS consumption. On the other hand, the evaluation of the physiological effects and health benefits of HS in clinical studies is most challenging. Therefore, this narrative review summarizes and discusses the physiological effects and health benefits of HS calyxes reported in clinical trials. Preparations obtained from HS calyxes (extracts, infusions, decoction, teas, beverages, capsules, and pills) are used as non-pharmacological therapies to prevent/control diverse chronic non-communicable diseases. The most-reported HS health benefits are its antihypertensive, antidyslipidemic, hypoglycemic, body fat mass reduction, nephroprotective, antianemic, antioxidant, anti-inflammatory, and anti-xerostomic activities; these effects are associated with the phytochemicals found in HS. Moreover, no adverse effects were reported during the clinical trials. However, clinical studies exhibited some limitations; thus, further studies are required to validate the clinical efficacy of HS in large-scale studies with higher doses and a good experimental design

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Effect of the roselle (Hibiscus sabdariffa L.) calyces drink on the physiological parameters of healthy adult subjects

Cited by 4 publications

References 18 publications

Antidyslipidemic, Antioxidant, and Anti-inflammatory Effects of Jelly Drink Containing Polyphenol-Rich Roselle Calyces Extract and Passion Fruit Juice with Pulp in Adults with Dyslipidemia: A Randomized, Double-Blind, Placebo-Controlled Trial

Antidyslipidemic, Antioxidant, and Anti-inflammatory Effects of Jelly Drink Containing Polyphenol-Rich Roselle Calyces Extract and Passion Fruit Juice with Pulp in Adults with Dyslipidemia: A Randomized, Double-Blind, Placebo-Controlled Trial

Exploring the Health Benefits and Therapeutic Potential of Roselle (Hibiscus sabdariffa) in Human Studies: A Comprehensive Review

Physiological Effects and Human Health Benefits of Hibiscus sabdariffa: A Review of Clinical Trials

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