Effect of the oral absorption of benzenesulfonanilide-type cyclooxygenase-1 inhibitors on analgesic action and gastric ulcer formation

Zheng, Xueli; Oda, Hiroyuki; Harada, Shun; Sugimoto, Yukihiko; Tai, Akihiro; Sasaki, Kenji; Kakuta, Hiroki

doi:10.1002/jps.21388

Cited by 3 publications

(2 citation statements)

References 28 publications

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“…Involvement of exogenous and endogenous prostaglandin in mucosal protection has well known (36,37). Cross-talks between the HO-1 system and the cyclooxygenase (COX) system have been demonstrated.…”

Section: Discussionmentioning

confidence: 99%

Polaprezinc (Zinc L-Carnosine) Is a Potent Inducer of Anti-oxidative Stress Enzyme, Heme Oxygenase (HO)-1 — a New Mechanism of Gastric Mucosal Protection

et al. 2009

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Abstract. Heme oxygenase (HO)-1 is implicated in cytoprotection in various organs. We tested a possibility that polaprezinc (PZ), an anti-ulcer drug, could induce HO-1 in the gastric mucosa. Male 6-week-old Wistar rats were intragastrically administered PZ. Gastric expression of HO-1 was assessed by real time RT-PCR and western blotting, and localization of HO-1 was observed by in situ hybridization and immunohistochemistry. The levels of HO-1 mRNA were increased in a dose-dependent manner. The levels of HO-1 mRNA were increased 4-fold by PZ at the dose of 200 mg/ kg at 3 h as compared with control levels. The levels of immunoreactive HO-1 were increased 3-fold at 6 h. Signals for HO-1 mRNA and immunoreactivity were detected strongly in the surface gastric mucosal cells and moderately in the gastric macrophages. Treatment with an HO-1 inhibitor, stannous mesoporphyrin (SnMP) significantly worsened the HCl-induced acute gastric mucosal lesions and increased the apoptosis of mucosal cells. Mucosal lesions were decreased by pretreatment with PZ, while they were increased by co-administration with SnMP. These data indicate for the first time that PZ is an effective inducer of HO-1 in the stomach. PZinduced HO-1 functions as a part of the mucosal protective effects of PZ.

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Section: Discussionmentioning

confidence: 99%

Polaprezinc (Zinc L-Carnosine) Is a Potent Inducer of Anti-oxidative Stress Enzyme, Heme Oxygenase (HO)-1 — a New Mechanism of Gastric Mucosal Protection

et al. 2009

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“…Cyclooxygenase-II is induced and expressed during inflammation, cell proliferation and angiogenesis. Cyclooxygenase-III is identified as a COX-I variant, and it's known to be inhibited by paracetamol [123][124][125]. Conventional COX inhibitors along with ibuprofen are acknowledged to have low selectivity and as a result might also result in ulcer, bleeding and gastroduodenal erosion.…”

Section: Iii-hcv Inhibitorsmentioning

confidence: 99%

Sulfonamides: Synthesis and the recent applications in Medicinal Chemistry

et al. 2020

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This review spotlights on sulfonamides from different sides, including history, structure-activity relationship, chemistry, methods of classification and up to date ways for their synthesis. Moreover, the review includes a discussion of the varied pharmacological effects of sulfonamides. Sulfonamides have a good range of pharmacological activities like oral diuretics (furosemide, indapamide, chlorthalidone, thiazides); anticancer (E7070), carbonic anhydrase (CA) inhibitors (CAIs) (acetazolamide, dichlorophenamide, dorzolamide and brinzolamide), antiepileptics (zonisamide and sulthiame), for rheumatoid arthritis (Sulfasalazine) antiviral (Darunavir) anti-inflammatory (celecoxib), antibacterial (Sulfadizine), as ophthamologicals (Dorzolamide) anticonvulsant (Zonisamide) cycloxygenase 2 (COX2) inhibitors (valdecoxib). These days, novel pills are launched, like apricoxib and pazopanib, which additionally include this organization. The sulfonamides competitively inhibit vitamin Bc synthesis in microorganisms and subsequently inhibit multiplication of bacteria but donot actively kill them. They need been used against most gram-positive and lots of gram-negative bacteria, also as some fungi.

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