Effect of the Normal Microbial Flora on Gastrointestinal Motility.

Abrams, Gerald D.; Bishop, Jane E.

doi:10.3181/00379727-126-32430

Cited by 220 publications

(94 citation statements)

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“…Gut flora is known to interact with gut mucosa by various metabolites such as short chain fatty acids, hydrogen, methane, and many other compounds (2,12,23). In his review Borriello (5) listed the following potential mechanisms: increased colonization, stimulation of cholecystokinin, possible increase of prostaglandin production.…”

Section: Discussionmentioning

confidence: 99%

Effects of Consumptionof a Milk Fermented by the Probiotic Strain Bifidobacterium animalis DN-173 010 on Colonic Transit Times in Healthy Humans

Bouvier¹,

Meance

Bouley

et al. 2001

Bioscience Microflora

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Section: Discussionmentioning

confidence: 99%

Effects of Consumptionof a Milk Fermented by the Probiotic Strain Bifidobacterium animalis DN-173 010 on Colonic Transit Times in Healthy Humans

Bouvier¹,

Meance

Bouley

et al. 2001

Bioscience Microflora

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“…The normal flora has been shown to accelerate the propulsion of gastro-intestinal contents (Abrams & Bishop, 1966, 1967, to reduce the volume of the caecum characteristically enlarged in germ-free and antibiotic-treated animals (Savage & Dubos, 1968; Waaij, 1969) and to produce volatile acids which are thought to inhibit the multiplication of Salmonella in the large bowel (Meynell, 1963;Bohnhoff, Miller & Martin, 1964a, b). In this respect it is important to note that the caecum volume of CRF-mice is normal and that the anaerobes isolated produce several volatile acids in vitro (Wensinck & Ruseler-van Embden, 1971).…”

Section: Discussionmentioning

confidence: 99%

Colonization resistance of the digestive tract in conventional and antibiotic-treated mice

Waaij

Vries

Wees

1971

J. Hyg.

778

378

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SUMMARYThe effect of oral administration of antibiotics on the intestinal flora of conventional mice and their resistance to colonization by orally introduced Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa was studied. Colonization resistance (CR) was expressed as the log of the oral bacterial dose followed by a persistent take in 50 % of the contaminated animals. The intestinal flora was virtually eliminated by the antibiotics and this elimination was accompanied by a precipitous fall of CR. CR gradually returned to normal values during the period of repopulation of the intestinal tract by the organisms surviving the treatment. Antibiotic treatment resulted in the disappearance of Enterobacteriaceae, enterococci, staphylococci and yeasts and, under appropriate housing conditions, the animals remained free of these organisms indefinitely. Germ-free mice contaminated with the intestinal flora of an antibiotic-treated animal and their offspring housed in a germ-free isolator showed high values of CR. Their intestinal flora consisted of anaerobic bacteria only. Apparently, these anaerobes are responsible for CR in these and in conventional mice.

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“…An important aspect of the indirect activity is the stimulation of intestinal peristaltic activity by the microflora (Abrams & Bishop, 1966).…”

Section: Introductionmentioning

confidence: 99%

Determination of the colonization resistance of the digestive tract of individual mice

Waaij

Berghuis

1974

J. Hyg.

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SUMMARYIt has been shown that it is possible to investigate the colonization resistance in individual mice by determining the concentration of a certain contaminant (s.R.-E. coli) in the faeces during the first 4 days after contamination. Experimental contamination is contra-indicated in many cases such as in individuals with decreased resistance to infection. Particularly in this group, the value of the colonization resistance should be determined. It appeared to be possible to determine the colonization resistance in such individuals by quantitative biotyping of the Enterobacteriaceae species in the faeces on several consecutive days.

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Effect of the Normal Microbial Flora on Gastrointestinal Motility.

Cited by 220 publications

References 0 publications

Effects of Consumptionof a Milk Fermented by the Probiotic Strain Bifidobacterium animalis DN-173 010 on Colonic Transit Times in Healthy Humans

Effects of Consumptionof a Milk Fermented by the Probiotic Strain Bifidobacterium animalis DN-173 010 on Colonic Transit Times in Healthy Humans

Colonization resistance of the digestive tract in conventional and antibiotic-treated mice

Determination of the colonization resistance of the digestive tract of individual mice

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