Effect of the new immunostimulator HAB 439 on cell-mediated immunity against intracellular bacteria

Dickneite, Gerhard; Schwab, W.; Schorlemmer, H. U.; Gebert, U.; Sedlacek, H.H.

doi:10.1016/0192-0561(91)90074-h

Cited by 5 publications

(1 citation statement)

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“…Immunostimulatory actions of therapeutics are equally important as immunosuppressive ones, and they are invaluable in the restoration of immune functions in immunocompromised individuals that are subjected to antibiotics and chemotherapy. In a study with HAB-439 isoxazoline derivative the compound appeared to be an inhibitor of aminopeptidase [ 33 ]. HAB-439 stimulated the DTH response to Salmonella typhimurium and Listeria monocytogenes .…”

Section: Resultsmentioning

confidence: 99%

Isoxazole Derivatives as Regulators of Immune Functions

2018

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In this review, we present reports on the immunoregulatory properties of isoxazole derivatives classified into several categories, such as immunosuppressive, anti-inflammatory, immunoregulatory, and immunostimulatory compounds. The compounds were tested in various models using resident cells from rodents and humans, cell lines, and experimental animal disease models corresponding to human clinical situations. Beneficial features of the described isoxazole derivatives include low toxicity and good bioactivity at low doses. In a majority of studies, the activities of investigated compounds were comparable or even higher than registered reference drugs. Whenever possible, a plausible mechanism of action of the investigated compounds and their potential therapeutic utility were proposed. Among the described compounds, particular attention was paid to the class of immune stimulators with a potential application in chemotherapy patients.

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Section: Resultsmentioning

confidence: 99%

Isoxazole Derivatives as Regulators of Immune Functions

2018

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Synthesis of 5‐Phosphonoisoxazoline N‐Oxides by Selective O‐Alkylation of Nitronate Anions

2015

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A series of 5‐phosphonoisoxazoline N‐oxides were prepared in good to excellent yields by selective O‐alkylation of nitronate anions with (α‐tosyloxyvinyl)phosphonates. A comprehensive study was undertaken to limit the competitive formation of the (β‐nitrocyclopropyl)phosphonate resulting from C‐alkylation of the ambident nitronate anions. The 5‐phosphonoisoxazoline N‐oxides thus formed were reduced to the corresponding 5‐phosphonoisoxazolines.

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Treatment of pregnant mice with antibiotics modulates the humoral response of the offspring: Role of prenatal and postnatal factors

Dostál

Soukupová

Horká

1994

International Journal of Immunopharmacology

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Effect of the new immunostimulator HAB 439 on cell-mediated immunity against intracellular bacteria

Cited by 5 publications

References 37 publications

Isoxazole Derivatives as Regulators of Immune Functions

Isoxazole Derivatives as Regulators of Immune Functions

Synthesis of 5‐Phosphonoisoxazoline N‐Oxides by Selective O‐Alkylation of Nitronate Anions

Treatment of pregnant mice with antibiotics modulates the humoral response of the offspring: Role of prenatal and postnatal factors

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Effect of the new immunostimulator HAB 439 on cell-mediated immunity against intracellular bacteria

Cited by 5 publications

References 37 publications

Isoxazole Derivatives as Regulators of Immune Functions

Isoxazole Derivatives as Regulators of Immune Functions

Synthesis of 5‐Phosphonoisoxazol­ine N‐Oxides by Selective O‐Alkylation of Nitronate Anions

Treatment of pregnant mice with antibiotics modulates the humoral response of the offspring: Role of prenatal and postnatal factors

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Synthesis of 5‐Phosphonoisoxazoline N‐Oxides by Selective O‐Alkylation of Nitronate Anions