Effect of the masseter muscle injection of botulinum toxin A on the mandibular bone growth of developmental rats

Jang

Park

et al. 2019

Background Botulinum toxin injection on the masticatory muscle induces the osteopenic condition on the ipsilateral condyle. Bisphosphonate suppresses bone resorption and is used to treat osteopenic or osteoporotic condition. This study aimed to evaluate the effect of bisphosphonate administration on prevention of condylar resorption and botulinum toxin A-induced disuse osteopenia in rats. Results The volume of the condyle and bone volume/tissue volume (BV/TV, %) showed a strong tendency towards statistical significance ( p = 0.052 and 0.058). Trabecular thickness (Tb.Th, mm) and trabecular number (Tb.N, 1/mm) were significantly smaller in the Botox group than in the other groups ( p < 0.05). The volume of the condyle and BV/TV in the bisphosphonate 100 and bisphosphonate 200 groups showed similar values when compared with the control group. Conclusion Bisphosphonate administration after botulinum toxin A injection in the masticatory muscles appears to prevent condyle resorption and botulinum toxin-induced disuse osteopenia in rats.

Section: Discussionmentioning

confidence: 99%

Effect of bisphosphonate on temporomandibular joint in osteopenia-induced rats by botulinum toxin A injection on masticatory muscle: a preliminary study

Jang

Park

et al. 2019

“…Injection of BTX-A on the anterior belly of the digastric muscle showed favorable results on preventing relapse of anterior open bite after trauma [ 5 ]. BTX-A injection into the masticatory muscle in growing rats has shown changes in jaw bone morphology [ 21 ]. Based on these results, BTX-A injection has been used for preventing relapse after orthognathic surgery [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

The effect of botulinum toxin-A injection into the masseter muscles on prevention of plate fracture and post-operative relapse in patients receiving orthognathic surgery

Shin

Kang

2018

Self Cite

BackgroundBotulinum toxin-A (BTX-A) injection into muscle reduces muscular power and may prevent post-operative complication after orthognathic surgery. The purpose of this study was (1) to evaluate BTX-A injection into the masseter muscle on the prevention of plate fracture and (2) to compare post-operative relapse between the BTX-A injection group and the no injection group.MethodsSixteen patients were included in this study. Eight patients received BTX-A injection bilaterally, and eight patients served as control. All patients received bilateral sagittal split ramus osteotomy for the mandibular setback and additional surgery, such as LeFort I osteotomy or genioplasty. Post-operative plate fracture was recorded. SNB angle, mandibular plane angle, and gonial angle were used for post-operative relapse.ResultsTotal number of fractured plates in patients was 2 out of 16 plates in the BTX-A injection group and that was 8 out of 16 plates in the no treatment group (P = 0.031). However, there were no significant differences in post-operative changes in SNB angle, mandibular plane angle, and gonial angle between groups (P > 0.05).ConclusionsBTX-A injection into the masseter muscle could reduce the incidence of plate fracture.

“…This study was approved by the Institutional Animal Care and Use Committee of the Gangneung-Wonju National University, Gangneung, Korea (2016-24). The experimental design and detailed procedure was in accord to our previous publication [15]. Ten Sprague Dawley rats were used in this study and divided into control and experimental groups, with five rats being used in each group.…”

Section: Methodsmentioning

confidence: 99%

“…Soft tissue originated tensional force may induce appositional bone growth [13]. In contrast, reduced tensional force by BTX injection may result in reduced bone growth [14, 15].…”

Section: Introductionmentioning

confidence: 99%

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Botulinum toxin A injection into the anterior belly of the digastric muscle increased the posterior width of the maxillary arch in developing rats

Ahn

et al. 2019

Self Cite

Background The purpose of this study was to evaluate the effects of botulinum toxin A (BTX) injection into the anterior belly of the digastric muscle on a growing rat. Methods Ten Sprague Dawley rats were used in this study. When the rats were 13 days old, 0.5 units of BTX was injected into the anterior belly of the digastric muscle for the experimental group ( n = 5). For the control, the same volume of normal saline was injected ( n = 5). The rats were sacrificed at 60 days old, and the skulls were harvested for micro-computed tomography (μCT) analysis. Results In anthropometric analysis, the zygomatic arch and mandibular bi-condylar width were significantly lower in the experimental group than those in the control group ( P = 0.025 and 0.027, respectively). The maxillary point width was significantly higher in the experimental group than that in the control group ( P = 0.020). Conclusion BTX injection into the anterior belly of the digastric muscle had effects on the maxillofacial bony width in growing rats.