Effect of the Marine Polyketide Plocabulin on Tumor Progression

Abstract

Marine sponges represent one of the richest sources of natural marine compounds with anticancer potential. Plocabulin (PM060184), a polyketide originally isolated from the sponge Lithoplocamia lithistoides, elicits its main anticancer properties binding tubulin, which still represents one of the most important targets for anticancer drugs. Plocabulin showed potent antitumor activity, in both in vitro and in vivo models of different types of cancers, mediated not only by its antitubulin activity, but also by its ability to block endothelial cell migration and invasion. The objective of this review is to offer a description of plocabulin’s mechanisms of action, with special emphasis on the antiangiogenic signals and the latest progress on its development as an anticancer agent.

Ten Years of Research on Fucoidan and Cancer: Focus on Its Antiangiogenic and Antimetastatic Effects

“…Numerous studies have indicated the important role of natural products in the oncological area [ 5 , 6 ]. In particular, several natural compounds have been found to target tumor-angiogenesis-associated cytokines, and apoptotic signaling pathways, such as curcumin, artemisinin, epigallocatechin gallate, resveratrol, emodin, celastrol, thymoquinone, plocabulin, and tocotrienols, have all shown prominent anti-angiogenic effects in the preclinical models of tumor angiogenesis [ 7 , 8 , 9 , 10 , 11 ].…”

“…Mar. Drugs 2023, 21, 307 2 of curcumin, artemisinin, epigallocatechin gallate, resveratrol, emodin, celastrol, thymoqu none, plocabulin, and tocotrienols, have all shown prominent anti-angiogenic effects the preclinical models of tumor angiogenesis [7][8][9][10][11].…”