Tubulin inhibitors. Selected scaffolds and main trends in the design of novel anticancer and antiparasitic agents

Design, synthesis and cytotoxic activity of molecular hybrids based on quinolin-8-yloxy and cinnamide hybrids and their apoptosis inducing property

“…7,8 In recent decades, a wide range of natural compounds and synthetic components have been identified as anticancer drugs that interfere with tubulin-microtubule dynamics. 9–11 The clinical success of such agents demonstrates that enormous potential of this target to the design and development of new anti-tubulin polymerization compounds as effective targeted anticancer regimens. 12…”