2013
DOI: 10.1155/2013/131372
|View full text |Cite
|
Sign up to set email alerts
|

Effect of theCopaifera langsdorffiiDesf. Leaf Extract on the Ethylene Glycol-Induced Nephrolithiasis in Rats

Abstract: The potential of the Copaifera langsdorffii leaves extract to prevent stone formation was analyzed by means of an ethylene glycol (EG) animal model of nephrolithiasis and an in vitro crystallization assay. Different doses of the C. langsdorffii leaves extract were administered to rats treated with EG. Urine biochemical parameters were quantified. CaOx deposits count and analysis of osteopontin expression were conducted on kidneys fixed in formalin. The in vitro assay was performed by turbidimetry. Phytochemica… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
15
0
5

Year Published

2015
2015
2023
2023

Publication Types

Select...
7
1

Relationship

1
7

Authors

Journals

citations
Cited by 25 publications
(24 citation statements)
references
References 30 publications
1
15
0
5
Order By: Relevance
“…(De Oliveira et al, 2013;Akyol et al, 2016). Karahindiba bitkisinde bulunan asidik gruplarının (fenolik asitlerin) kristalin aktif büyüyen yüzeylerine adsorpsiyonunun ve de -COOH grupları ile Ca 2+ kristalitlerinin etkileşiminin kalsiyum oksalat çökmesini engellediği düşünülmektedir.…”
Section: Bulgular Ve Tartişmaunclassified
See 1 more Smart Citation
“…(De Oliveira et al, 2013;Akyol et al, 2016). Karahindiba bitkisinde bulunan asidik gruplarının (fenolik asitlerin) kristalin aktif büyüyen yüzeylerine adsorpsiyonunun ve de -COOH grupları ile Ca 2+ kristalitlerinin etkileşiminin kalsiyum oksalat çökmesini engellediği düşünülmektedir.…”
Section: Bulgular Ve Tartişmaunclassified
“…Ayrıca, torexacin, retinol, levulin, inulin gibi bileşikler içerir (Anonim, 2016). Karahindiba kristalizasyon engelleyici olarak etkili olduğu düşünülen fenolik asit bakımından da zengin bir bitkidir (Oliveira et al, 2013;Ivanov, 2014).…”
Section: Introductionunclassified
“…kidney stone formation, in vaginal cream on the reproductive performance of female rats among others [6,[8][9][10][11][12]. Nevertheless, there is no data concerning its effect on human immune cells.…”
Section: Introductionmentioning
confidence: 99%
“…Sendo assim, animais tratados com extrato hidroalcoólico de C. langsdorffii demonstraram que a média da massa total dos cálculos foi discretamente menor em comparação ao grupo controle (BRANCALION et al, 2012). Em outro estudo foi avaliado o potencial profilático do extrato no tratamento de pedras renais em ratos induzidos a nefrolitíase por etilenoglicol (OLIVEIRA et al, 2013).…”
Section: Figura 1 Copaifera Langsdorffii Medindo Cerca De 7 M De Altunclassified
“…De acordo com Schimidt; Gonzalez & Derendorf (2010) é possível prever a atividade farmacológica de uma substância, quando a mesma é encontrada na forma livre no seu sítio de ação. Contextualizando esta afirmação, pode-se inferir que a presença de metabólitos secundário de C. langsdorffii nos rins dos animais, pode estar relacionada com a cura/prevenção (BRANCALION et al, 2012;OLIVEIRA et al, 2013) da urolitíase.…”
Section: Estudos Farmacocinéticosunclassified