Effect of the homogeneity of the column set on the performance of a simulated moving bed unit

9.08 Use of Industrial Scale Chromatography in Pharmaceutical Manufacturing

“…Moreover, because each column will be rotating through all the positions, they all must be identical as the SMB performance is strongly linked to the performance of the worst column. 40,41 The 'train' of columns defines four zones that are delimited by the inlet/outlet streams (eluent and feed inlet, extract and raffinate outlet). The two middle zones (II and III) are the separation zones.…”

BioSMB™ Technology: Continuous Countercurrent Chromatography Enabling a Fully Disposable Process

“…The reason is that lower -resolution processes require more consistency and similarity in the performance of the different beds in the process [32] . …”

Simulated Moving Bed Chromatography: From Concept to Proof‐of‐Concept

“…The most common modeling strategies assume that all SMB columns have identical characteristics, however, the packing procedure can be quite irreproducible [206], which might play a main role in the quality of SMB separations [207,208]. Consequently, once the operator runs an SMB unit with the theoretically optimized operating parameters, the differences between columns arise and different values from the expected ones can appear.…”