Effect of the glycemic control on intracellular cytokine production from peripheral blood mononuclear cells of type 1 and type 2 diabetic patients

Foss‐Freitas, Maria Cristina; Foss, Norma T.; Donadi, Eduardo Antônio; Foss, Milton César

doi:10.1016/j.diabres.2008.09.003

Cited by 16 publications

(8 citation statements)

References 20 publications

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“…TNF-α is highly involved with macrophage activation and increased serum TNF-α level have been observed in insulin resistance stages and diabetes mellitus development [48], however, inconsistency still existed and no meta-analysis was conducted about the change of serum TNF-α level in T1DM patients. The results of this study clearly demonstrate that T1DM patients had significantly elevated serum level of TNF-α and significant correlation existed between TNF-α level and patients’ age, disease duration and ethnicity.…”

Section: Discussionmentioning

confidence: 99%

The change of serum tumor necrosis factor alpha in patients with type 1 diabetes mellitus: A systematic review and meta-analysis

et al. 2017

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ObjectiveThe aim of this study was used meta-analysis to investigate changes of serum tumor necrosis factor-alpha (TNF-α) in patients with type 1 diabetes mellitus (T1DM).MethodsRelevant literatures were identified from PubMed, Cochrane Library, CNKI, WanFang and Chinese-Cqvip databases (published from January 1, 1999 to September 30, 2016). Eligible reports were included for pooled analysis of serum TNF-α level and subgroup analysis was performed in relation with age, disease duration and ethnicity.ResultsA total of 23 articles (1631 T1DM cases, 1429 healthy controls) were included for this meta-analysis. Compared with the controls, the patients had significantly increased serum TNF-α level (P < 0.001). Similar results were also found among all subgroup analysis of different age, disease duration and ethnicity (with the exception of Asian) (all P < 0.05). Regression analysis indicated that age (P = 0.680), disease duration (P = 0.957), and ethnicity (P = 0.526) of patients were not significant impact factors for the high heterogeneity. The results were stable according to the sensitivity analysis and no publication bias existed in this meta-analysis.ConclusionsSerum TNF-α level in T1DM patients has significantly elevated among all age, disease duration and ethnicity groups.

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Section: Discussionmentioning

confidence: 99%

The change of serum tumor necrosis factor alpha in patients with type 1 diabetes mellitus: A systematic review and meta-analysis

et al. 2017

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“…Moreover, the finding of increased IL-8, and lack of changes in other cytokines, could argue that the degree of metabolic control has a more specific influence on the regulation of particular inflammatory mediators rather than on the general, pro-inflammatory state associated with T1DM. Indeed, IL-8 has most consistently been shown to be increased in both adults [27, 28] and children [29, 30] with TIDM. Additionally, MCP-1 was also increased in adults and children with T1DM and was associated with worse metabolic control [31, 32].…”

Section: Discussionmentioning

confidence: 99%

Increased circulating IL-8 is associated with reduced IGF-1 and related to poor metabolic control in adolescents with type 1 diabetes mellitus

et al. 2009

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Background-A dysregulated growth hormone (GH)/insulin-like growth factor 1 (IGF-1) axis is well-recognized in children and adolescents with type 1 diabetes mellitus (T1DM). Decreased IGF-1 levels can also be found in chronic inflammatory diseases, while hyperglycemia promotes inflammatory cytokine production. Therefore, inflammatory cytokines may link poor metabolic control with GH/IGF-1 axis changes. This study examined the relationship between serum inflammatory cytokines and IGF-1 in adolescents (age 13-18) with TIDM in chronic poor (n=17) or favorable (n=19) glucose control. Poor control (PC) was defined as ≥ 3, consistent HbA1C > 9% during the previous 2 years, while favorable control (FC) was consistent levels of HbA1C < 9%.Results-HbA1C (FC: 7.5±0.6%; PC: 10.5±0.9%, p<0.001) and interleukin (IL)-8 (FC: 3.7±4.0 pg/ml; PC: 7.4±4.3 pg/ml, p=0.01) were increased and IGF-1 (FC: 536.5±164.3 ng/ml; PC: 408.9 ±157.1 ng/ml, p=0.03) was decreased in patients with poor control compared to patients with favorable control. Moreover, IL-8 was inversely correlated with IGF-1 (r=−0.40, p=0.03) and positively correlated with HbA1C (r=0.36, p=0.03).Conclusions-In adolescents with T1DM and chronic, poor glucose control, increased serum IL-8 is associated with reduced IGF-1 suggesting a pro-inflammatory milieu that may contribute to alterations in the GH/IGF-1 axis.

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“…Many studies 43 demonstrate that glucotoxicity might also influence cytokine and chemokine production. Therefore, the higher levels of CXCL10 in the cholecalciferol group than in the placebo group may be explained by the higher HbA 1c level in the treatment vs placebo group at the beginning of the study.…”

Section: Commentmentioning

confidence: 99%

Effect of Cholecalciferol as Adjunctive Therapy With Insulin on Protective Immunologic Profile and Decline of Residual β-Cell Function in New-Onset Type 1 Diabetes Mellitus

Gabbay¹,

Sato²,

Finazzo³

et al. 2012

Arch Pediatr Adolesc Med

119

118

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Effect of the glycemic control on intracellular cytokine production from peripheral blood mononuclear cells of type 1 and type 2 diabetic patients

Cited by 16 publications

References 20 publications

The change of serum tumor necrosis factor alpha in patients with type 1 diabetes mellitus: A systematic review and meta-analysis

The change of serum tumor necrosis factor alpha in patients with type 1 diabetes mellitus: A systematic review and meta-analysis

Increased circulating IL-8 is associated with reduced IGF-1 and related to poor metabolic control in adolescents with type 1 diabetes mellitus

Effect of Cholecalciferol as Adjunctive Therapy With Insulin on Protective Immunologic Profile and Decline of Residual β-Cell Function in New-Onset Type 1 Diabetes Mellitus

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