The change of serum tumor necrosis factor alpha in patients with type 1 diabetes mellitus: A systematic review and meta-analysis

Abstract

ObjectiveThe aim of this study was used meta-analysis to investigate changes of serum tumor necrosis factor-alpha (TNF-α) in patients with type 1 diabetes mellitus (T1DM).MethodsRelevant literatures were identified from PubMed, Cochrane Library, CNKI, WanFang and Chinese-Cqvip databases (published from January 1, 1999 to September 30, 2016). Eligible reports were included for pooled analysis of serum TNF-α level and subgroup analysis was performed in relation with age, disease duration and ethnicity.ResultsA total of 23 articles (1631 T1DM cases, 1429 healthy controls) were included for this meta-analysis. Compared with the controls, the patients had significantly increased serum TNF-α level (P < 0.001). Similar results were also found among all subgroup analysis of different age, disease duration and ethnicity (with the exception of Asian) (all P < 0.05). Regression analysis indicated that age (P = 0.680), disease duration (P = 0.957), and ethnicity (P = 0.526) of patients were not significant impact factors for the high heterogeneity. The results were stable according to the sensitivity analysis and no publication bias existed in this meta-analysis.ConclusionsSerum TNF-α level in T1DM patients has significantly elevated among all age, disease duration and ethnicity groups.

Soluble CD163 correlates with lipid metabolic adaptations in type 1 diabetes patients during ketoacidosis

“…However, in these studies, approximately twofold higher concentrations of sCD163 were measured (3.5 mg/L vs 7.0 mg/ L) 10,25 . The lower peak concentration found might to some extent be explained by the negative feedback from TNF-a, which is chronically elevated in type 1 diabetes, hence a downregulation of CD163 on macrophages and less shedding in response to LPS 26,27 . Furthermore, sCD163 correlated positively with the two associated inflammatory cytokines, IL-6 and IL-10, in line with previous findings in septic patients 28 .…”

Elevated Serum TNF-α Is Related to Obesity in Type 2 Diabetes Mellitus and Is Associated with Glycemic Control and Insulin Resistance

“…Moreover, TNF-α by inducing serine phosphorylation of insulin receptor substrate-1 can act as an inhibitor of peripheral insulin action which leads to insulin resistance [4]. Two recent meta-analyses indicated that both patients with type 1 and type 2 DM have significantly elevated levels of serum TNF-α which showed a positive correlation with insulin resistance [5,6]. In obese T2DM patients, the TNF-α plasma level is related to the amount of visceral fat and is not instantly affected in poorly controlled diabetic patients by acute lowering of blood glucose level [7].…”

Co-morbidity of type 1 diabetes and endometriosis: bringing a new paradigm into focus

“…Tumor necrosis factor-alpha (TNF-α) is implicated in the pathogenesis of ENDO, since its levels are increased in peritoneal fluids of ENDO women by virtue of activated peritoneal macrophages infiltrating lesions and correlate with disease severity and with size and numbers of active lesions (Birt et al 2013, Kocbek et al 2016. Similarly, serum TNF-α levels are elevated in T1DM patients, regardless of age, disease duration, and ethnicity (Qiao et al 2017). By using non-obese diabetic mice, Lee et al (2005) demonstrated that TNF-α initiates T1DM autoimmunity by regulating the maturation of dendritic cells, leading to the activation of islet-specific pancreatic lymph node T-cells.…”