Effect of the form of the sesame-based diet on the absorption of lignans

Papadakis, Emmanouil-Nikolaos; Lazarou, Despina; Grougnet, Raphaë͏l; Magiatis, Prokopios; Skaltsounis, Alexios Léandros; Papadopoulou‐Mourkidou, Euphemia; Papadopoulos, Andrew

doi:10.1017/s0007114508978272

Cited by 14 publications

(17 citation statements)

References 21 publications

(31 reference statements)

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“…Twenty percent of sesame or flaxseed in the experimental diets used might be considered a high amount for typical western diets. However, if consistent amount of sesame in the order of tens of grams/meal is consumed, it might be close to human intake when consuming Middle Eastern diets, where sesame can be eaten in form of spread (tahina) or dietary oil [35], although the form of the sesame preparations may affect the absorption of lignans [41]. Flaxseed can also be consumed at higher amount in far eastern diets as boiled seeds and as flour in bread or biscuits [36].…”

Section: Discussionmentioning

confidence: 99%

Oilseeds ameliorate metabolic parameters in male mice, while contained lignans inhibit 3T3-L1 adipocyte differentiation in vitro

et al. 2014

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Purpose and background The focus was directed to the study of two of the most lignan-rich food sources: sesame and flaxseeds. Recent epidemiological and experimental evidences suggesting that these foods may improve metabolic functions underlying metabolic syndrome (MetS). Methods To characterize the effect of these oilseeds on metabolic functions, we conducted an experimental study aimed at preventing adiposity and metabolic imbalance in a mouse model of high-fat diet (HFD)-induced MetS. Statistical analysis was performed by two-way analysis of variance test followed by post hoc Bonferroni analysis. Results We studied the effect of the oilseeds sesame and flaxseed on metabolic parameters in mice on a HFD. When the HFD was integrated with 20 % of sesame or flaxseed flours, the mice showed a decrease in body fat, already at day 15, from time 0. The size of the adipocytes was smaller in epididymal fat, liver steatosis was inhibited, and insulin sensitivity was higher in mice on the supplemented diets. The supplemented diets also resulted in a significant increase in the serum levels of the lignan metabolites enterodiol and enterolactone compared with the controls. The expression of genes associated with the inflammatory response, glucose metabolism, adipose metabolism and nuclear receptor were altered by the oilseed-supplemented diets. Some of the most abundant lignans in these oilseeds were studied in 3T3-L1 preadipocyte cells and were effective in inhibiting adipocyte differentiation at the minimal dose of 1 nM. Conclusions The consumption of sesame and flaxseed may be beneficial to decrease metabolic parameters that are generally altered in MetS.

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Section: Discussionmentioning

confidence: 99%

Oilseeds ameliorate metabolic parameters in male mice, while contained lignans inhibit 3T3-L1 adipocyte differentiation in vitro

et al. 2014

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“…17 In humans, flavonoids, such as quercetin, as well as the lignan sesamin, are absorbed in the gut, and their bioavailability is much greater than previously believed. [63][64][65] Systolic blood pressure and plasma-oxidized, low-density lipoprotein concentrations are reduced on quercetin intake in overweight subjects. 66 Recent studies have reported the powerful properties of various natural polyphenols against oxidative stress in several cellular and in vivo paradigms of neurodegenerative disease.…”

Section: Discussionmentioning

confidence: 99%

Quercetin and Sesamin Protect Neuronal PC12 Cells from High-Glucose-Induced Oxidation, Nitrosative Stress, and Apoptosis

Bournival

Francoeur

Renaud

et al. 2012

Rejuvenation Research

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Complications of diabetes are now well-known to affect sensory, motor, and autonomic nerves. Diabetes is also thought to be involved in neurodegenerative processes characteristic of several neurodegenerative diseases. Indeed, it has been acknowledged recently that hyperglycemia-induced oxidative stress contributes to numerous cellular reactions typical of central nervous system deterioration. The goal of the present study was to evaluate the effects of the polyphenol quercetin and the lignan sesamin on high-glucose (HG)-induced oxidative damage in an in vitro model of dopaminergic neurons, neuronal PC12 cells. When incubated with HG (13.5 mg/mL), neuronal PC12 cells showed a significant increase of cellular death. Our results revealed that quercetin and sesamin defend neuronal PC12 cells from HG-induced cellular demise. An elevated level of reactive oxygen and nitrogen species is a consequence of improved oxidative stress after HG administration, and we demonstrated that this production diminishes with quercetin and sesamin treatment. We also found that quercetin and sesamin elicited an increment of superoxide dismutase activity. DNA fragmentation, Bax/Bcl-2 ratio, nuclear translocation of apoptosis-inducing factor, as well as poly(adenosine diphosphate [ADP]-ribose) polymerase cleavage were significantly reduced by quercetin and sesamin administration, affirming their antiapoptotic features. Also, HG treatment impacted caspase-3 cleavage, supporting caspase-3-dependent pathways as mechanisms of apoptotic death. Our results indicate a powerful role for these natural dietary compounds and emphasize preventive or complementary nutritional strategies for diabetes control.

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“…et al reported that the levels of enterolignans (i.e. enterolactone and enterodiole, which are the end metabolites of lignans in mammals and express strong phyto-oestrogenic activity) were increased dramatically in the plasma of Wistar rats receiving sesame for 8 weeks (26). In a same experiment on Wistar rats supplied for 8 weeks with a diet rich in sesame, Anagnostis A. et al evaluated the expression of oestrogen receptors (ERalpha and ERbeta) in the uterus tissue (27).…”

Section: Discussionmentioning

confidence: 99%

Sesame a Treatment of Menstrual Bleeding Cessation in Iranian Traditional Medicine: Results From a Pilot Study

et al. 2014

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Background:There is an increasing demand for alternative medicine methods in treatment of menstrual bleeding cessation and oligomenorrhea. Sesamum indicum L. is a well-known medication in the Avicenna traditional medicine to induce menstrual bleeding in women with oligomenorrhea. Objectives: This study is the first effort to evaluate the efficacy of this treatment on the patients suffers from oligomenorrhea. Patients and Methods: A pilot study was carried out on 21 cases of oligomenorrhea having complaint of menstruation retard for more than two weeks admitted to Beheshti hospital clinic. Patients who had not used hormonal chemical or herbal drugs and were not pregnant or lactating were enrolled and received sesame once daily for 7 days per oral. Patients were followed for 7 weeks after drug administration. Result: 85% of the patients experienced menstrual bleeding after receiving sesame treatment by two weeks. The mean interval before menstruation upon treatment was 9.8 days while the mean postponement time after the last patients' menstruation, before treatment, was 92 days. Blood flow and pain during menstruation were not significantly higher than past menstruation episodes. No untoward side effect was noticed during clinical trial. The next menstruation episode follow up demonstrated that 80% of the patients had menstruation without using any drug with a delay of less than 2 weeks. Conclusion: In conclusion, the results of this pilot study demonstrated that Sesamum indicum L. may be an effective choice in inducing bleeding in women with oligomenorrhea that has ignorable side effects compare to the current hormonal therapies. Thus, stronger clinical trials with control group are recommended to strength this hypothesis.

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Effect of the form of the sesame-based diet on the absorption of lignans

Cited by 14 publications

References 21 publications

Oilseeds ameliorate metabolic parameters in male mice, while contained lignans inhibit 3T3-L1 adipocyte differentiation in vitro

Oilseeds ameliorate metabolic parameters in male mice, while contained lignans inhibit 3T3-L1 adipocyte differentiation in vitro

Quercetin and Sesamin Protect Neuronal PC12 Cells from High-Glucose-Induced Oxidation, Nitrosative Stress, and Apoptosis

Sesame a Treatment of Menstrual Bleeding Cessation in Iranian Traditional Medicine: Results From a Pilot Study

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