Effect of the difference of bone turnover on peri‐titanium implant osteogenesis in ovariectomized rats

Abstract

High and low bone turnover situations, both of which are typically observed as postmenopausal and senile osteoporosis, were created by ovariectomy (OVX), and then an investigation of whether or not the difference of bone turnover affected peri-titanium (Ti) implant osteogenesis in rats was conducted. Female rats were divided into four groups. The experimental and control groups underwent OVX or sham operations at 15 or 27 weeks of age, as high or low bone turnover groups, respectively. Ti implants were inserted into the tibiae at 30 weeks, then fluorochromes were injected 10 or 20 days after the implantation for histometry. The implants were retained for 30 days and then ground sections were prepared. Afterward, the cortical bone growth rate, bone contact ratio (BCR) of the implant in both the cortical bone area and medullary canal area, and the average trabecular bone thickness around the implant were evaluated. Biochemical markers of bone turnover were also measured. Biochemical measurements indicated both increasing osteocalcin production in OVX rats and decreasing tartrate-resistant acid phosphatase activity in the low-turnover group. Histometrical measurements showed decreasing cortical growth and low BCR in the medullary canal of the low-turnover group. The high-turnover group demonstrated BCR as high as that of the control group. There was no significant difference in the average trabecular bone thickness around the implant among the groups. As a result, two types of osteoporotic situations were confirmed and it was shown that the difference of bone turnover was clearly due to the diverse osteogenesis around the Ti implant.

The Alternation of Peri-Implant Bone Response Exposed to Static Lateral Load

“…These results imply that after 1 days, bone turnover increased with both osteoblastic and osteoclastic promotion; however, bone resorption is supposed to be more strongly promoted than formation. This is similar to findings in rats with ovariectomy-induced osteoporosis (39) . After 7 days, only BMP-2 indicated slight decrease in its expression and the expression of other proteins showed no differences from control.…”

Osteogenicity of titanium implants coated with calcium phosphate or collagen type-I in osteoporotic rats

“…Interestingly, animal experiments already demonstrated that estrogen deficiency induced osteoporosis significantly influences the contact as made by the newly formed bone with an implant surface [10,11].…”

Histological comparison between implants retrieved from patients with and without osteoporosis

“…The successful outcome of dental implantation is influenced by a number of confounding factors such as the boneremodeling response, implant design and topography, clinical protocols, and the patient's level of physical activity 6,19 . Bone quality is another important factor, with a higher failure rate having been observed in implants placed at type IV bone 12,14,23 .…”