Effect of the dietary fiber glucomannan on chronic constipation in neurologically impaired children

Staiano, Annamaria; Simeone, Domenico; Giudice, Ennio Del; Miele, Erasmo; Tozzi, Arturo; Toraldo, Caterina

doi:10.1016/s0022-3476(00)90047-7

Cited by 106 publications

(73 citation statements)

References 14 publications

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“…6,8,10,12 Regarding total and segmental colonic transit times, it is difficult to compare our results with the few studies found in the literature, considering that distinct therapy regimens 14,16,24,25 or patients with constipation associated with neurological involvement were analyzed. 15 Regarding our patients with clinical symptoms improved upon Our data also show a higher probability of laxative need after 1 year of treatment in patients with persistence of delayed total colonic transit time at the sixth week of treatment, underscoring the importance of the initial phase of treatment. In Dutch children with functional constipation treated with a therapy regimen similar to that used in the present study, the authors observed that a negative evolution after 1 year of treatment was associated with a total colonic transit time higher than 100 hours.…”

Section: Discussionsupporting

confidence: 58%

“…Only a few articles have analyzed the evolution of the colonic transit time during conventional treatment of chronic constipation, some of them focusing on the effect of dietary fibers or prokinetic drugs on transit time. [12][13][14][15][16] Therefore, the objective of the present study is to analyze the effects of conventional treatment of chronic functional constipation in patients attending a referral outpatient clinic on clinical symptoms, total and segmental colonic transit times, and lactulose and bean test meal orocecal transit times. Chronic constipation was characterized by hard stools that were painful or difficult to pass, associated or not with longer intervals between evacuations, blood mixed with stools, fecal retention, and soiling for over a 3-month period.…”

Section: Introductionmentioning

confidence: 99%

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Efeito do tratamento convencional da constipação crônica funcional no tempo de trânsito orocecal e colônico total e segmentar

Soares¹,

Tahan²,

Morais³

2009

J. Pediatr. (Rio J.)

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No conflicts of interest declared concerning the publication of this article. Methods: A total of 34 consecutive patients with functional constipation attending a specialized outpatient clinic were included in the study. Total and segmental colonic transit times were assessed using radiopaque markers. Hydrogen breath test was used to evaluate lactulose and bean orocecal transit times. Treatment consisted of disimpaction, general and dietary fiber intake instruction, and mineral oil administration.Results: At admission, colonic dysmotility was found in 71.9% (23/32) of patients. All patients who complied with the treatment showed improvement of clinical symptoms after 6 weeks of treatment, when 82.6% (19/23) of those with dysmotility at admission returned to normal or reduced the severity of colonic transit patterns. Transit time decreased (medians) between admission and eighth week of treatment: lactulose orocecal transit (from 70 to 50 minutes, p = 0.002), bean orocecal transit (from 240 to 220 minutes, p = 0.002), and total colonic transit (from 69.5 to 37.0 hours, p = 0.001). The need for mineral oil therapy for constipation after a 12-month treatment was associated with persistence of total colonic transit higher than 62 hours at the eighth week of treatment (p = 0.014). Conclusion:The conventional therapeutic approach yielded good results regardless of the presence or not of colonic dysmotility at inclusion in the study. Digestive tract motility abnormalities in functionally constipated children may be reversed, and may be secondary to constipation.

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Section: Discussionsupporting

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Efeito do tratamento convencional da constipação crônica funcional no tempo de trânsito orocecal e colônico total e segmentar

Soares¹,

Tahan²,

Morais³

2009

J. Pediatr. (Rio J.)

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“…After giving glucomannan 100 mg/kg twice a day for 12 weeks, this study found improvements in the stool frequency and found no meaningful side effect after the therapy. 17 In this study, we found no nervous disorders. The subjects were given glucomannan with a dose of 100 mg/kg/day during 4 weeks, with average weight 25 kg, so each subjects have 2.5 grams glucomannan per day.…”

Section: Discussionmentioning

confidence: 41%

The role of glucomannan fiber in childhood functional constipation

Aulia

Supriatmo

Azlin

et al. 2016

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“…It has been demonstrated that this product is highly effective in the treatment of obesity due to the satiety sensation that it produces [10,11]; as a remedy for constipation, because it increases the feces volume [12]; as hypocholesterolemic agent, interfering in the transport of cholesterol and of bile acids [10,13]; and as hypoglycemic and hypoinsulinemic agent probably by delaying gastric emptying and slowing glucose delivery to the intestinal mucosa [14].…”

Section: Introductionmentioning

confidence: 99%

Effect of glucomannan and the dosage form on ethinylestradiol oral absorption in rabbits

González¹,

Fernández²,

Sahagún³

et al. 2004

Contraception

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To the beneficial properties of dietary fiber in human health, several disadvantages can be added as the possible modification of the bioavailability of other drugs when administered by the oral route. In this study, the influence of glucomannan in the oral bioavailability of ethinyl estradiol (EE), when administered to female rabbits in two different dosage forms (enteric capsules and dispersed in water), was established. To carry out the study, three groups of six animals each were used. All animals received 1 mg kg À1 oral EE, and rabbits in groups 2 and 3 received 1.5 g glucomannan dispersed in water or in enteric capsules, respectively, immediately before EE. When comparing the results obtained after the administration of EE/glucomannan dispersed in water with those obtained after the administration of this estrogen without fiber, we can see that C max is 1.4 times lower, AUC 1.9 times lower and that t max is identical (10 min). However, after the administration of fiber in enteric capsules, AUC and C max are higher (4.1 and 7.8 times, respectively) than when the estrogen was administered alone, and also, there is a delay in t max (20 min). After the administration of glucomannan in the enteric capsule, the fiber forms, as in the stomach, a highly viscous solution in the gut that would limit EE access to the mucosal surface delaying its absorption. However, this effect could be compensated by a reduction of EE metabolism in the intestinal wall, leading to a higher absorption of the estrogen. D 2004 Elsevier Inc. All rights reserved.

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Effect of the dietary fiber glucomannan on chronic constipation in neurologically impaired children

Cited by 106 publications

References 14 publications

Efeito do tratamento convencional da constipação crônica funcional no tempo de trânsito orocecal e colônico total e segmentar

Efeito do tratamento convencional da constipação crônica funcional no tempo de trânsito orocecal e colônico total e segmentar

The role of glucomannan fiber in childhood functional constipation

Effect of glucomannan and the dosage form on ethinylestradiol oral absorption in rabbits

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