Effect of the Basidiomycete Poria cocos on Experimental Dermatitis and Other Inflammatory Conditions.

Cuéllar, M. J.; Giner, Rosa M.; Recio, M. C.; Just, María José; Máñez, Salvador; Rı́os, José Luis

doi:10.1248/cpb.45.492

Cited by 50 publications

(37 citation statements)

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“…Moreover, it has become clear that Hoelen has inhibitory activities on TPA induced inflammation (Nukaya et al, 1996;Cuellar et al, 1997) and phospholipase A 2 (Cuellar et al, 1996) that induces the liberation of arachidonic acid, which is the precursor of many eicosanoids responsible for inflammatory responses. So, Hoelen, inhibitor of phospholipase A 2 , may have a favorable action on certain diseases such as rheumatoid arthritis, psoriasis, autoimmune uveitis, septic shock and bronchial asthma (Kaiser et al, 1990;Mukherjee et al, 1992) The direct protection of RBC membrane from freeradical attack as observed in the present study would provide an important pathophysiological basis for making use of helpful hemorrheological and anti-atherosclerotic effects of Hoelen.…”

Section: Discussionmentioning

confidence: 99%

Inhibitory effects of triterpenes isolated from Hoelen on free radical‐induced lysis of red blood cells

Sekiya

Goto

Shimada

et al. 2003

Phytotherapy Research

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Hoelen, sclederma of Poria cocos Wolf, has long been used as a sedative and diuretic in traditional medicine. Formerly, we demonstrated that Hoelen in vitro protects red blood cells from AAPH-induced hemolysis. In this study, tests were carried out to identify the main ingredient of Hoelen that has the scavenging effect on free-radicals. Triterpene carboxylic acids isolated from the methanol extract of Hoelen, i.e. pachymic acid, polyporenic acid, 3-epidehydrotumulosic acid, 3beta-hydroxylanosta-7,9(11), 24-trien-21-oic acid and 3-o-acetyl-16 alpha -hydroxytrametenolic acid, were found to have inhibitory activities against AAPH-induced lysis of red blood cells.

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Section: Discussionmentioning

confidence: 99%

Inhibitory effects of triterpenes isolated from Hoelen on free radical‐induced lysis of red blood cells

Sekiya

Goto

Shimada

et al. 2003

Phytotherapy Research

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“…Por su parte, la fracción en éter de petróleo de hojas a 100 mg/Kg de peso dio un 60.77 % y la fracción de diclorometano en igual concentración dio un 50.48% de inhibición. La fracción con mayor actividad inhibitoria fue la de éter de petróleo de corteza a 100 mg/Kg de peso, que mostró un 70.02% de inhibición al compararse con el antiinfl amatorio comercial indometacina (5 mg/Kg) por el método del edema plantar inducida con carragenina (Cuellar et al, 1997). La actividad se le atribuye a la presencia de ácidos triterpénicos presentes en esta fracción y que fueron aislados de este estudio.…”

Section: Resultados Y Discusionunclassified

“…La actividad se le atribuye a la presencia de ácidos triterpénicos presentes en esta fracción y que fueron aislados de este estudio. Triterpenos tetraciclicos aislados de Burseraceas (Commiphora mukul) parecidos estructuralmente a los aquí obtenidos y conocidos como guggulteroles I y III tienen una signifi cativa actividad antiinfl amatoria (Chander et al, 1996), igualmente presentan actividad antiinfl amatoria compuestos como ácido 3β,16α-dihidroxilanosta-7,9(11)24-trien-21-oico aislados de Poria cocos (Cuellar et al, 1997).…”

Section: Resultados Y Discusionunclassified

Triterpenos aislados de corteza de Bursera graveolens (Burseraceae) y su actividad biologica

Robles¹,

Torrenegra²,

Gray³

et al. 2005

Rev. bras. farmacogn.

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INTRODUCCIONLas plantas de la familia Burseraceas se caracterizan por ser árboles o arbustos con sustancias resinosas en casi todos los órganos, presentan canales resiníferos y balsamíferos en el interior de la corteza (Cuatrecasas J. 1957;Swart 1942).Ocho géneros están representados en América, seis de los cuales son endémicos y entre los que se encuentra el género Bursera, que alberga cuatro especies entre ellas Bursera graveolens que es conocida comúnmente como caraño, sasafrás o tatamaco (Cuatrecasas 1957).B. graveolens se encuentra distribuida desde Yucatán por Centroamérica hasta Colombia y Perú. La resina producida por esta especie es usada en medicina popular en el tratamiento de hernias, tronchaduras de los pies y para extraer cuerpos extraños de la piel (García-Barriga, 1992). Según Mendieta (1981) los extractos en ron de hojas y cortezas son aplicados localmente para lavar heridas y en forma oral son usados contra el asma, la diarrea, cálculos en el riñón (Bernal et al., 1990).Según García-Barriga (1992), de esta especie se han realizado algunos estudios fi toquímicos que reportan la presencia de aceites esenciales ricos en monoterpenos y sesquiterpenos, ácido elémico (C 35 H 45 O 4 ), ácido resínico I y II. Bernal; Correa (1990) comenta también la obtención de un compuesto oleánico (ácido 2,3-secoolean-12-en-2,3,28-tricarboxilico) y algunos de sus derivados además de una lactona.En este artículo nosotros describimos el aislamiento y la identifi cación de tres triterpenos tetraciclicos derivados del esqueleto del tirucalano que se caracterizan por tener una oxidación en el C-3, un ácido carboxílico en el C-21 y una insaturación en el C-24, y que no han sido reportados con anterioridad para esta especie. Además, la presencia de estos triterpenos del tipo tirucalano, mostrando oxidación en el C-21 tienen una importancia quimiotaxonómica, debido a que son los precursores de un grupo de compuestos modifi cados a partir de ellos que se han aislado de las familias relacionadas a las Burseraceae, mientras estos se han aislados de esta familia Gray, 1987;.Algunas evaluaciones de actividad antimicrobiana y antiinfl amatoria tanto de los extractos etanólicos como de algunas fracciones de hojas y cortezas de B. graveolens, se realizaron basados en algunos reportes que indican la presencia de triterpenos tetraciclicos responsables de la actividad antimicrobiana mostrada por resinas de especies del género Protium y Tetragastris (Gray et al., ABSTRACT: Bursera graveolens (Burseraceae), known in Colombia as "sasafrás", is useful for its medicinal properties and is rich in secondary metabolites. In our research, we carried out antimicrobial tests of several fractions and ethanolic extracts from aerial parts against Bacillus subtilis and Staphylococcus aureus, that showed growth inhibitory activity when applied at 250 mg/mL for extracts and 150 mg/mL for fractions. We carried out an antiinfl amatory assay also, that showed 71% of inhibition by extracts (81% of Indomethacin) and 70% of inhibition by fractions (78% of I...

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“…Previous studies have demonstrated that the surface layer of P. cocos has a remarkable diuretic effect (Zhao et al 2012;Feng et al 2013a), which has been tested for treatment of early renal injury and chronic kidney disease in rats (Zhao et al 2013a-c); Furthermore, dried sclerotia of P. cocos was verified to have anti-inflammatory and hypoglycemic effects in prediabetes mellitus rats (Lee et al 2014). Triterpenes as the major active compounds of P. cocos are mainly derived from a lanostane skeleton (Rios 2011), which have been reported to manage psoriasis, rheumatoid arthritis, septic shock, autoimmune uveitis and bronchial asthma (Cuellar et al 1997;Giner et al 2000;Spelman et al 2006). However, the antiepileptic effects of triterpenes as well as underlying mechanisms remain to be determined.…”

Section: Introductionmentioning

confidence: 99%

Antiepileptic activity of total triterpenes isolated fromPoria cocosis mediated by suppression of aspartic and glutamic acids in the brain

Gao

Yan

Jin³

et al. 2016

Pharmaceutical Biology

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Context: Triterpenes from Poria cocos Wolf (Polyporaceae) have been used to treat various diseases in traditional Chinese medicine. However, the antiepileptic effects and mechanism are not fully understood. Objective: The objective of this study is to investigate the antiepileptic properties of total triterpenes (TTP) from the whole P. cocos. Materials and methods: The ethanol extract TTP was identified by HPLC fingerprint analysis. Male ICR mice were gavaged (i.g.) with TTP (5, 20, 80 or 160 mg/kg) or reference drugs twice a day for 7 d. Antiepileptic activities of TTP were evaluated by maximal electroshock (MES)-and pentylenetetrazole (PTZ)-induced seizures in mice for 30 and 60 min, respectively. Locomotor activity and Rota-rod tests were performed for 60 min and 5 min, respectively. The levels of glutamic acid (Glu), aspartic acid (Asp), c-aminobutyric acid (GABA) and glycine (Gly) in convulsive mice were estimated. The chronic epileptic model of Wistar rats was built to measure expressions of glutamate decarboxylase 65 (GAD65) and GABA A in rat brain after TTP treatment. Results: The LC 50 of TTP (i.g.) was above 6 g/kg. TTP (5-160 mg/kg) protected mice against MES-and PTZinduced convulsions at 65.0% and 62.5%, respectively, but have no effect on rota-rod treadmill; TTP (20-160 mg/kg) significantly reduced the locomotor activities, shortened the onset of pentobarbital sodium-induced sleep; TTP decreased Glu and Asp levels in convulsive mice, but increased the GAD65 and GABA A expressions in chronic epileptic rats at doses usage. Discussion and conclusion: TTP extracted from P. cocos possessed potential antiepileptic properties and is a candidate for further antiepileptic drug development. ARTICLE HISTORY

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Effect of the Basidiomycete Poria cocos on Experimental Dermatitis and Other Inflammatory Conditions.

Cited by 50 publications

References 1 publication

Inhibitory effects of triterpenes isolated from Hoelen on free radical‐induced lysis of red blood cells

Inhibitory effects of triterpenes isolated from Hoelen on free radical‐induced lysis of red blood cells

Triterpenos aislados de corteza de Bursera graveolens (Burseraceae) y su actividad biologica

Antiepileptic activity of total triterpenes isolated fromPoria cocosis mediated by suppression of aspartic and glutamic acids in the brain

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