Effect of the administration of flunixin meglumine on pregnancy rates in Holstein heifers

Güzeloğlu, Aydın; Erdem, Hüseyin; Saribay, Mustafa Kemal; Thatcher, W.W.; Tekeli, Tevfik

doi:10.1136/vr.160.12.404

Cited by 29 publications

(32 citation statements)

References 21 publications

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“…Failure of the conceptus to block luteolysis is one cause of pregnancy loss because administration of a PG synthesis inhibitor increased pregnancy rate in heifers (Guzeloglu et al 2007). The larger size and greater IFNT2 secretory activity of the CSF2-treated conceptus should improve its ability to prevent luteolysis and allow continuation of pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Consequences of conceptus exposure to colony-stimulating factor 2 on survival, elongation, interferon-τ secretion, and gene expression

Loureiro¹,

Block

Favoreto

et al. 2011

Reproduction

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Exposure of bovine conceptuses to colony-stimulating factor 2 (CSF2) from days 5 to 7 of development can increase the percentage of transferred conceptuses that develop to term. The purpose of this experiment was to understand the mechanism by which CSF2 increases embryonic and fetal survival. Conceptuses were produced in vitro in the presence or absence of 10 ng/ml CSF2 from days 5 to 7 after insemination, transferred into cows, and flushed from the uterus at day 15 of pregnancy. There was a tendency (PZ0.07) for the proportion of cows with a recovered conceptus to be greater for those receiving a CSF2-treated conceptus (35% for control versus 66% for CSF2). Antiviral activity in uterine flushings, a measure of the amount of interferon-t (IFNT2) secreted by the conceptus, tended to be greater for cows receiving CSF2-treated conceptuses than for cows receiving control conceptuses. This difference approached significance when only cows with detectable antiviral activity were considered (PZ0.07). In addition, CSF2 increased mRNA for IFNT2 (PZ0.08) and keratin 18 (P!0.05) in extraembryonic membranes. Among a subset of filamentous conceptuses that were analyzed by microarray hybridization, there was no effect of CSF2 on gene expression in the embryonic disc or extraembryonic membranes. Results suggest that the increase in calving rate caused by CSF2 treatment involves, in part, more extensive development of extraembryonic membranes and capacity of the conceptus to secrete IFNT2 at day 15 of pregnancy.

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Section: Discussionmentioning

confidence: 99%

Consequences of conceptus exposure to colony-stimulating factor 2 on survival, elongation, interferon-τ secretion, and gene expression

Loureiro¹,

Block

Favoreto

et al. 2011

Reproduction

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“…In the reproductive sphere, its use is reported in studies related to female bovine, reducing PGF 2α production, increasing pregnancy rates in heifers (GUZELOGLU et al 2007) and increasing in vitro production of embryos (KIM et al 2014). …”

Section: Resultsmentioning

confidence: 99%

“…One prostaglandin, Flunixin Meglumine, has stood out due to its modulation activity in the production of PGF 2α , which has been useful to extend the luteal phase in the estral cycle of sheep (AKÉ-LOPEZ et al, 2005) and to assist biotechniques, such as embryo transfer in bovines (CARDOSO, 2009) and to improve pregnancy rates in reproductive protocols of heifers (GUZELOGLU et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Effect of Flunixin Meglumine administration on seminal characteristics of male sheep and goat

Neto

Rodrigues

Leles

et al. 2017

SCA

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Testicular degeneration is a multifactorial process increasing the concentration of prostaglandins in seminal plasma. Both increase and decrease of these hormones tend to promote loss of seminal quality. Flunixin meglumine is a potent anti-inflammatory drug capable of modulating the production of prostaglandins and is widely used in female reproduction. However, it is rarely used in males with the same objective. Therefore, this study aimed to evaluate the effects of this drug on seminal quality of male lambs and goats with spermatic characteristics unfavorable for reproduction. To this end, a total of 15 breeding animals were evaluated, of which six goats and four sheep with poor seminal quality were selected according to the criteria established by the Brazilian College of Animal Reproduction (CBRA). Three semen samples were collected from each animal. Then, the flunixin meglumine treatment was initiated and ejaculates were collected at two different periods after the drug was administered (from day 21 until day 35 and from day 49 to day 63). Macroscopic and microscopic parameters were assessed in semen samples and scrotal circumference and percentages of sperm pathologies were measured and compared between the three periods. Data with normal distribution were analyzed using ANOVA at 5% probability, and comparisons between periods within the same species were performed using the Tukey test. An improvement was observed in the analyses of mass motility, percentage motility, and sperm vigor. Scrotal circumference had no variation. Concerning sperm pathologies, an increase in the number of normal spermatozoids was observed due to a significant reduction in minor and major defects, and the latter remained low even after the treatment was finished. Therefore, flunixin meglumine presented beneficial effects on seminal parameters of male goats and lamb with unfavorable spermatic characteristics. These findings indicate this drug may be used in the treating of males with testicular injuries or of breeders with reduced seminal quality due to advanced age. Key words: Andrology. Animal Reproduction. Prostaglandins. Seminal Quality. ResumoA degeneração testicular é um processo multifatorial que leva ao aumento das prostaglandinas no plasma do ejaculado, sendo que tanto seu acréscimo quanto a redução baixam a qualidade seminal. A Flunixina Meglumine é um potente anti-inflamatório, capaz de modular a produção de prostaglandinas, amplamente difundido na reprodução de fêmeas, mas pouco utilizado em machos para esse fim. Por isso, esse trabalho buscou avaliar o efeito deste fármaco sobre a qualidade seminal de machos ovinos e caprinos que apresentem quadro espermático desfavorável à reprodução. Para tanto, um total de 15 reprodutores pertencentes à Universidade Federal do Ceará foram avaliados, dos quais foram selecionados seis bodes e quatro carneiros com sêmen de baixa qualidade, segundo os critérios do Colégio Brasileiro de Reprodução Animal (CBRA). Foram realizadas três colheitas prévias de cada animal, aplicado o ...

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“…Koblischke et al detected higher pregnancy rates of mares receiving flunixin meglumine and vedaprofen simultaneously when compared to untreated mares [5]. In cattle, administration of flunixin meglumine at the time of embryo transfer or before maternal recognition of gestation increased pregnancy rates according to Scenna et al [6] and Guzeloglu et al [11] although, similar studies did not show beneficial effects of flunixin meglumine treatment in bovines [12,13]. In mice, it has been shown that flunixin meglumine has no detrimental effects on embryonic survival and implantation [14], but possible beneficial effects of flunixin meglumine or other NSAIDs in pregnancy have not been reported yet.…”

Section: Introductionmentioning

confidence: 98%

Administration of the nonsteroidal anti-inflammatory drug tolfenamic acid at embryo transfer improves maintenance of pregnancy and embryo survival in recipient mice

Schlapp

Goyeneche

Fernandez

et al. 2015

J Assist Reprod Genet

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Purpose To evaluate the effect of the nonsteroidal antiinflammatory drugs tolfenamic acid and flunixin meglumine in pregnancy rate and embryo survival of recipient mice subjected to embryo transfer. Methods A total of 142 recipient females were transferred with 2,931 embryos and treated with a single injection of tolfenamic acid (1 mg/kg; n=54 females with 1,129 embryos), flunixin meglumine (2.5 mg/kg; n=46 females with 942 embryos), or bi-distilled water (10 mL/kg) as control group (n=42 females with 860 embryos). Pregnancy was checked 2 weeks after embryo transfer, delivery was registered on the due date, and litter size was recorded on Day 7 after birth. Results Pregnancy rate of tolfenamic acid treated females was significantly higher than flunixin group (P<0.05) and showed a tendency to be higher when compared to the control group (P=0.06). The number of pups born from transferred embryos in pregnant females was significantly higher for both treatment groups compared to controls (P<0.05). Number of pups from total transferred embryos was higher for both treatment groups (P<0.05) when compared to controls. Conclusion The use of tolfenamic acid at the time of embryo transfer improves both pregnancy rate and number of live pups in recipient mice, with optimal effects observed with flunixin meglumine. We suggest that the use of tolfenamic acid has beneficial effects on the maintenance of pregnancy and embryo survival in recipient mice, which should be taken into account for further studies in other mammalian females.

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Effect of the administration of flunixin meglumine on pregnancy rates in Holstein heifers

Cited by 29 publications

References 21 publications

Consequences of conceptus exposure to colony-stimulating factor 2 on survival, elongation, interferon-τ secretion, and gene expression

Consequences of conceptus exposure to colony-stimulating factor 2 on survival, elongation, interferon-τ secretion, and gene expression

Effect of Flunixin Meglumine administration on seminal characteristics of male sheep and goat

Administration of the nonsteroidal anti-inflammatory drug tolfenamic acid at embryo transfer improves maintenance of pregnancy and embryo survival in recipient mice

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