Effect of teriparatide on early sinus graft healing in the ovariectomized rabbit

Abstract

Objectives The purpose of this study was to determine the effect of administering intermittent parathyroid hormone 1–34 [teriparatide, (PTH)] on the maxillary sinus lift and bone grafting in osteoporotic rabbits induced by ovariectomy and glucocorticoid. Materials and methods Ovariectomies were performed on 20 female New Zealand white rabbits that were randomly divided into two groups: (a) the PTH group (n = 10), in which 10 μg kg−1 day−1 PTH was injected subcutaneously 5 days a week for 5 weeks (from 1 week before until 4 weeks after sinus surgery), and (b) the saline group (n = 10), in which saline substituted PTH at the same dose, mode of administration, and duration. Bone grafting with bovine bone mineral was augmented into 13 sinuses, and bone grafts and implants were simultaneously performed in seven sinuses, in both groups. Animals were sacrificed at 4 weeks after surgery. To determine whether PTH was an effective treatment for osteoporosis, we measured the bone mineral density (BMD) of the right femur using micro‐computed tomography and performed radiographic and histometric analyses of the maxillary sinus surgery site. The Mann–Whitney test was used for statistical analysis. Results It was found that BMD increased in the femur, whereas none of the radiographic and histometric parameters differed significantly between the groups in the sinus, while there were large interindividual variations within groups. Conclusions These findings suggest that intermittent PTH does not promote new bone formation in the augmented maxillary sinus of ovariectomized rabbits.

Preventive effect of teriparatide on medication-related osteonecrosis of the jaw in rats

“…TPD consists of 34 amino-terminals and has high sequence conservation in rats and humans; hence, the experiment was conducted in rats 31 . Moreover, because mice and humans show similar calcium metabolism 18 , they are most often used as animal models for bone metabolic disease studies 16 , 32 . In this study, radiological and histological evaluations were performed on the proximal tibia to evaluate the systemic effect of the drug.…”

Different responses of heterogeneous graft presentations in bone reconstructions during sinus lift elevation surgery: an immunolabeling and histomorphometric study performed in rabbits

“…Animal models are considered the first choice for preclinical testing of productions that seek to improve bone repair (21). Rabbits were selected here because of their maxillary sinus model, because they have similar characteristics to human maxillary sinuses, and because they allow the reproduction of maxillary sinus elevation as well as its grafting (22). However, bone healing in rabbits can be completed quickly, given a high metabolic rate that is higher than that found in humans.…”

Hypoxia Pathway in Osteoporosis: Laboratory Data for Clinical Prospects

“…Treatment can be divided into drug therapy, physical therapy and other measures. Drugs include antiresorptive drugs, osteogenesis drugs and other researched drugs or small molecular compounds such as bisphosphonates and their derivatives, cathepsin K inhibitors, calcitonin, estrogen, selective estrogen receptor modulators [ 25 , 26 , 27 ], calcium-sensitive receptor antagonists, the sclerosing protein antibody EVENITY, Wnt signal agonists and antibody therapy, endogenous Wnt signal inhibitors, parathyroid hormone analogues [ 28 , 29 , 30 , 31 ], metformin, vitamin K2, strontium salt, active VD and its analogues and so on [ 32 , 33 , 34 , 35 ]. Physical therapies include mechanical stimulation, damp-heat therapy, electromagnetic therapy and static magnetic field therapy [ 17 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 ].…”