Effect of Terfenadine on Substance P and Vasoactive Intestinal Polypeptide Concentrations in Nasal Secretions from Patients with Nasal Allergy

Abstract

Before terfenadine treatment, the mean substance P and vasoactive intestinal polypeptide (VIP) concentrations in nasal secretions from nasal allergy patients tended to be higher than the values of healthy subjects. During terfenadine treatment, the mean substance P concentrations in nasal secretions from patients allergic to house dust or pollen were significantly decreased to 62 and 39% of the initial values, respectively. The mean VIP concentrations in nasal secretions from the house dust allergy patients and the pollen allergy patients were significantly decreased to 52 and 18% of the initial values, respectively. Plasma substance P and VIP concentrations were not affected by nasal allergic symptom and terfenadine treatment.

Elevated levels of substance P in tears of patients with allergic conjunctivitis and vernal keratoconjunctivitis

“…The elute was concentrated by spin vacuum evaporation, lyophilized, and stored at -40°C until assayed. Enzyme immunoassay for SP was performed as previously reporled [3,18]. Antiserum RA-08-095 (Cambridge Research Biochemicals Ltd, Cambridge.…”

Effect of terfenadine on TNFα release from peripheral blood mononuclear cells during cow's milk allergy

“…In addition, terfenadine down-regulates the expression of adhesion molecules such as ICAM-I on nasal epithelial cells 1111, thus decreasing the recruitment of inflammatory cells. Tertenadine also inhibits the release of neuropeptides such as substance P and vasoaetive intestinal polypeptide in nasal mucosa [4].…”