Effect of tempol on the passive avoidance and novel object recognition task in diabetic rats

Jabbarpour, Zahra; Shahidi, Siamak; Saidijam, Massoud; Sarihi, Abdolrahman; Hassanzadeh, Taghi; Esmaeili, Rasoul

doi:10.1016/j.brainresbull.2013.12.013

Cited by 46 publications

(26 citation statements)

References 55 publications

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“…Glycated hemoglobin reflects the previous two to three months of glycemic control (37). These results confirm previous studies that tempol has hypoglycemic properties (25,38,39). Our results are similar to a previous study that demonstrated oral tempol treatment of diabetic mice during eight weeks, reduced plasma glucose (40).…”

Section: Discussionsupporting

confidence: 82%

The Effects of the Synthetic Antioxidant, Tempol, on Serum Glucose and Lipid Profile of Diabetic and Non-Diabetic Rats

Shahidi¹,

Jabbarpour²,

Saidijam³

et al. 2016

Avicenna J Med Biochem

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Background: Hyperlipidemia and low antioxidant levels is one the diabetes side effects. Some studies have indicated the possible effects of nutrients on the improvement of hyperlipidemia, by their antioxidants ingredients. Objectives: The aim of the present study was to evaluate the effect of the synthetic antioxidant, tempol, on blood lipid profiles and glucose levels in healthy and diabetic rats. Materials and Methods: Adult Wistar rats were randomly divided to four experimental groups including, healthy control, diabetic control, diabetic receiving tempol and healthy receiving tempol groups. Diabetes was induced by injection of streptozotocin (60 mg/kg, Intraperitoneally (IP)). The rats were then fed saline or tempol (30 mg/kg) by gavage for 60 days. Blood samples were collected by cardiac puncture. Next, glucose, high-density lipoprotein (HDL), low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), cholesterol, triglyceride and HbA1c were measured by specific kits. Also, the coronary risk index was calculated. Results: The blood glucose level increased following diabetes induction. The level of blood glucose in the diabetic receiving tempol group decreased compared to the control diabetic group. The comparison of LDL, VLDL, cholesterol, triglyceride, HbA1c and coronary risk index among experimental groups indicated the increase of these factors in the diabetic group. High-density lipoprotein in the diabetic groups was lower than the other groups. Conclusions: It can be concluded that tempol can improve dyslipidemia and may decrease hyperglycemia in diabetes. It seems that antioxidants such as tempol can improve dyslipidemia and may decrease hyperglycemia in diabetes.

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Section: Discussionsupporting

confidence: 82%

The Effects of the Synthetic Antioxidant, Tempol, on Serum Glucose and Lipid Profile of Diabetic and Non-Diabetic Rats

Shahidi¹,

Jabbarpour²,

Saidijam³

et al. 2016

Avicenna J Med Biochem

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“…However, in healthy young subjects, normal oxidative stress levels are significantly decreased by potent antioxidant treatment and memory and cognitive function are impaired. Normal oxidative stress is necessary for induction of signaling pathways in cognitive processing and if neutralized or not enough superoxide is generated, and this leads to deficient synaptic plasticity and cognitive problems [9, 27]. Therefore, the results of the present study may clarify the effectiveness of CoQ10 in improving cognitive function in healthy middle-aged and DM-induced rats.…”

Section: Introductionmentioning

confidence: 80%

“…Recognition memory is a form of declarative memory that measures the ability of animals to judge or discriminate between objects based on visual and tactile information. Basically, this test was performed according to our previous report [9]. It consists of a cubic open area and a video recording system.…”

Section: Methodsmentioning

confidence: 99%

“…Fasting blood glucose levels were determined before and 3 days after STZ injection and at the end of the experiment. Animals were considered diabetic if plasma glucose levels exceeded 250 mg/dL [6-9]. …”

Section: Methodsmentioning

confidence: 99%

“…DM affects the function of many organs and exerts significant effects on the structure and function of the nervous system [1-4]. Cognitive functions, learning, and memory are impaired in DM in humans and in diabetic animal models [5-9]. Healthy older subjects experience cognitive deficits, which are increased in diabetic adults [10].…”

Section: Introductionmentioning

confidence: 99%

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Influence of Chronic Coenzyme Q10 Supplementation on Cognitive Function, Learning, and Memory in Healthy and Diabetic Middle-Aged Rats

2018

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Diabetes mellitus can induce impairment in learning and memory. Cognitive and memory deficits are common in older adults and especially in those with diabetes. This is mainly because of hyperglycemia, oxidative stress, and vascular abnormalities. Coenzyme Q10 (CoQ10) can decrease oxidative stress, hyperglycemia, and inflammatory markers, and improve vascular function. Therefore, the aim of the present study was to investigate the possible effects of CoQ10 on cognitive function, learning, and memory in middle-aged healthy and diabetic rats. Adult middle-aged male Wistar rats (390–460 g, 12–13 months old) were divided into 6 experimental groups. Diabetes was induced by a single i.p. injection of streptozotocin (60 mg/kg). CoQ10 (20 or 120 mg/kg, orally by gavage) was administered for 45 days. The cognitive function and learning memory of rats were evaluated using novel object recognition (NOR) and passive avoidance tests. The discrimination index of the NOR test in the diabetic groups receiving CoQ10 (20 or 120 mg/kg) and the healthy group receiving CoQ10 (120 mg/kg) was significantly higher than that in the control group. In addition, the step through latency was significantly longer and the time spent in the dark compartment was significantly shorter in the diabetic groups receiving CoQ10 than in the control group. CoQ10 supplementation can improve learning and memory deficits induced by diabetes in older subjects. In addition, CoQ10 at higher doses can improve cognitive performance in older healthy subjects.

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The effect of chronic stimulation of serotonin receptor type 7 on recognition, passive avoidance memory, hippocampal long-term potentiation, and neuronal apoptosis in the amyloid β protein treated rat

et al. 2018

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Effect of tempol on the passive avoidance and novel object recognition task in diabetic rats

Cited by 46 publications

References 55 publications

The Effects of the Synthetic Antioxidant, Tempol, on Serum Glucose and Lipid Profile of Diabetic and Non-Diabetic Rats

The Effects of the Synthetic Antioxidant, Tempol, on Serum Glucose and Lipid Profile of Diabetic and Non-Diabetic Rats

Influence of Chronic Coenzyme Q10 Supplementation on Cognitive Function, Learning, and Memory in Healthy and Diabetic Middle-Aged Rats

The effect of chronic stimulation of serotonin receptor type 7 on recognition, passive avoidance memory, hippocampal long-term potentiation, and neuronal apoptosis in the amyloid β protein treated rat

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