Effect of Telmisartan on Ambulatory Blood Pressure Monitoring, Plasma Brain Natriuretic Peptide, and Oxidative Status of Serum Albumin in Hemodialysis Patients

Shimada, Hirokazu; Kitamura, Kenichiro; Anraku, Makoto; Miyoshi, Takuji; Adachi, Masataka; Tuyển, Đỗ Gia; Wakamatsu, Shiho; Nonoguchi, Hiroshi; Tanaka, Motoko; Tomita, Kimio

doi:10.1291/hypres.28.987

Cited by 16 publications

(16 citation statements)

References 53 publications

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“…As in previous studies (6,20), the Kolmogorov-Smirnov algorithm was used to determine whether each variable had a normal distribution. Comparisons of baseline data among the groups were performed with unpaired Student's t test.…”

Section: Discussionmentioning

confidence: 99%

Telmisartan Shows an Equivalent Effect of Vitamin C in Further Improving Endothelial Dysfunction After Glycemia Normalization in Type 1 Diabetes

Ceriello

Piconi²,

Esposito

et al. 2007

Diabetes Care

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OBJECTIVE -Long-lasting hyperglycemia in type 1 diabetic patients induces permanent alterations of endothelial function by increased oxidative stress, even when glycemia is normalized.RESEARCH DESIGN AND METHODS -In this study, 36 type 1 diabetic patients and 12 control subjects were enrolled. The diabetic patients were divided into three groups. The first group was treated for 24 h with insulin, achieving a near normalization of glycemia. After 12 h of this treatment, vitamin C was added for the remaining 12 h. The second group was treated for 24 h with vitamin C. After 12 h of this treatment, insulin was started, achieving a near normalization of glycemia for the remaining 12 h. The third group was treated for 24 h with both vitamin C and insulin, achieving near normalization of glycemia. The same protocols were performed after 1 month of telmisartan or placebo.RESULTS -Neither normalization of glycemia nor vitamin C treatment alone was able to normalize endothelial dysfunction or oxidative stress. Combining insulin and vitamin C normalized endothelial dysfunction and decreased oxidative stress to normal levels. Telmisartan significantly improved basal endothelial function and decreased nitrotyrosine plasma levels. In patients treated with telmisartan, a near normalization of both flow-mediated vasodilation and oxidative stress was achieved when glycemia was normalized, whereas adding vitamin C infusion did not show further effect on endothelial function or nitrotyrosine plasma levels.CONCLUSIONS -These data indicate that combining the normalization of glycemia with an antioxidant can normalize endothelial function in type 1 diabetic patients and that telmisartan works as an antioxidant like vitamin C. Diabetes Care 30:1694-1698, 2007A n increase in the incidence of macrovascular diseases in type 1 diabetes has long been recognized (1). The acceleration of macrovascular disease is partly due to the increased incidence of classical risk factors such as hypertension and dyslipidemia (2). However, recent evidence suggests that hyperglycemia also plays a significant role (3).The endothelium is a major organ involved in the development of cardiovascular disease (CVD), even in diabetes, and the presence of endothelial dysfunction has often been reported in diabetes and been found to be an independent predictor of future CVD (4).Several studies have shown that hyperglycemia induces endothelial dysfunction in both diabetic and nondiabetic subjects (5-7); however, in type 1 diabetic patients, endothelial dysfunction has been reported to be present, even when normoglycemia is achieved (8,9).Evidence indicates that hyperglycemia induces endothelial dysfunction through the generation of oxidative stress (10), which has been suggested to be the key player in the generation of both micro-and macrovascular diabetes complications (11). We have recently demonstrated that a near normalization of endothelial dysfunction can be achieved in type 1 diabetic patients by combining an optimal control of glycemia with the infusion of t...

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Section: Discussionmentioning

confidence: 99%

Telmisartan Shows an Equivalent Effect of Vitamin C in Further Improving Endothelial Dysfunction After Glycemia Normalization in Type 1 Diabetes

Ceriello

Piconi²,

Esposito

et al. 2007

Diabetes Care

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show abstract

“…We recently demonstrated that telmisartan effectively lowered the extent of BP and reduced oxidative stress and that it is safe and well-tolerated by HD patients (17). Interestingly, the reduction of oxidative stress by olmesartan was slightly higher than that by telmisartan.…”

Section: Discussionmentioning

confidence: 97%

“…Then 5 μL aliquots of serum were analyzed on a Shodex Asahipak ES-502N column (Showa Denko Co., Ltd., Tokyo, Japan). From the HPLC profile, the content of each albumin fraction (human mercaptalbumin, f[HMA]; human nonmercaptalbumin-1, f[HNA-1]; human nonmercaptalbumin-2, f[HNA-2]) was estimated as the area of the HNA fraction divided by the HMA fraction of the serum albumin peak (17).…”

Section: Chromatography Of Serum Albuminmentioning

confidence: 99%

“…The radiation-generated H2O2 was removed by treatment with catalase (154 U/ mL). After the addition of the assay reagents and standing at room temperature for 30 min, absorbances were measured at 560 nm and converted to concentrations using the molar absorption coefficient of 3.70 × 10 4 mol/L/cm (17).…”

Section: Protein Hydroperoxidesmentioning

confidence: 99%

“…The aim of this study was to examine the possible antioxidant and free radical-scavenging properties of olmesartan in in vitro studies. We also evaluated the effect of once daily administration of 40 mg of olmesartan on BP and on oxidized serum albumin, a marker of protein oxidation, in HD patients (16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

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