Olmesartan protects endothelial cells against oxidative stress-mediated cellular injury

Kadowaki, Daisuke; Anraku, Makoto; Sakaya, Moe; Hirata, Sumio; Maruyama, Toru; Otagiri, Masaki

doi:10.1007/s10157-015-1111-5

Cited by 14 publications

(13 citation statements)

References 34 publications

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“…On the contrary, olmesartan, an AT1 receptor blocker (ARB), was also shown to have high antioxidant activity, with effects similar to those reported previously [ 18 – 20 ] in model rats with ANG-II-induced hypertension. However, ARBs can elevate serum uric acid levels [ 33 ].…”

Section: Discussionsupporting

confidence: 73%

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Benzbromarone Attenuates Oxidative Stress in Angiotensin II‐ and Salt‐Induced Hypertensive Model Rats

Muraya

Kadowaki

Miyamura

et al. 2018

Oxidative Medicine and Cellular Longevity

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Oxidative stress induced by hyperuricemia is closely associated with the renin-angiotensin system, as well as the onset and progression of cardiovascular disease (CVD) and chronic kidney disease (CKD). It is therefore important to reduce oxidative stress to treat hyperuricemia. We previously found that benzbromarone, a uricosuric agent, has a direct free radical scavenging effect in vitro. The antioxidant effects of benzbromarone were evaluated in vivo via oral administration of benzbromarone for 4 weeks to model rats with angiotensin II- and salt-induced hypertension. Benzbromarone did not alter plasma uric acid levels or blood pressure but significantly reduced the levels of advanced oxidation protein products, which are oxidative stress markers. Furthermore, dihydroethidium staining of the kidney revealed a reduction in oxidative stress after benzbromarone administration. These results suggest that benzbromarone has a direct antioxidant effect in vivo and great potential to prevent CVD and CKD.

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Section: Discussionsupporting

confidence: 73%

“…The results were then compared with those of model rats treated with olmesartan, an AT1 receptor blocker with antioxidant activity. These rats served as a positive control [ 18 – 20 ].…”

Section: Introductionmentioning

confidence: 99%

Benzbromarone Attenuates Oxidative Stress in Angiotensin II‐ and Salt‐Induced Hypertensive Model Rats

Muraya

Kadowaki

Miyamura

et al. 2018

Oxidative Medicine and Cellular Longevity

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“…This may give another explanation for the anti-arthritic effect of ramipril which was shown in the current study to have anti-inflammatory and antioxidant potentials represented as corrected serum MPO, CRP, MDA and GSH levels. In agreement, interference with RAS activation was reported to have anti-inflammatory and antioxidant effects in different animal models (Chandran et al, 2014;Li et al, 2014;Kadowaki et al, 2015). Recently, the AT-1 receptor blocker telmisartan was reported to exert anti-inflammatory and anti-osteoclastic activity in mice with RA (Queiroz-Junior et al, 2015), and even in other models with inflammatory reactions like bronchial asthma (Abdel-Fattah et al, 2015).…”

Section: -Discussionmentioning

confidence: 77%

Ramipril and haloperidol as promising approaches in managing rheumatoid arthritis in rats

Wahba

Messiha

Abo-Saif

2015

European Journal of Pharmacology

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“…Many pathological conditions are linked to the accumulation of AOPPs, including osteoarthritis [30], uremia, Fig. 1 Schematic diagram of the roles and mechanisms of AOPPs in atherosclerosis.…”

Section: The Roles Of Aopps In Atherosclerosismentioning

confidence: 99%

The Characteristics and Roles of Advanced Oxidation Protein Products in Atherosclerosis

Huang

Zhang

et al. 2016

Cardiovasc Toxicol

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Advanced oxidation protein products (AOPPs) are novel biomarkers of oxidative damage to proteins and a novel class of inflammatory mediators. AOPPs can promote oxidative stress (OS) and inflammation and thus participate in many pathophysiological disease processes. Atherosclerosis is a chronic inflammatory disease of blood vessels that is characterized by low-density lipoprotein infiltration into the endothelial intima and the formation of atherosclerotic plaques. Inflammation and OS are established risk factors for the formation of atherosclerosis. Accumulated studies show that AOPPs can accelerate the progression of atherosclerosis through OS and inflammation. Additionally, AOPPs can accelerate the formation of atherosclerotic plaques by inhibiting high-density lipoprotein receptor scavenger receptor class B type I-mediated high-density lipoprotein cholesterol reverse transport, leading to metabolic disturbances. Some studies have suggested that plasma AOPPs levels are independently positively correlated with blood pressure and are also independent risk factors for cardiovascular disease. AOPPs can trigger oxidative bursts of neutrophils, monocytes and phagocytic cells, increase the generation of reactive oxygen species and promote the secretion of cytokines to accelerate endothelial cell injury. Detecting the levels and inhibiting the formation of AOPPs may provide a novel approach to monitor the progress and improve the prognosis of atherosclerosis.

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Olmesartan protects endothelial cells against oxidative stress-mediated cellular injury

Abstract: These results demonstrated that the antioxidant activity of olmesartan might contribute to both its vasculoprotective and anti-hypertensive effects.

Cited by 14 publications

References 34 publications

Benzbromarone Attenuates Oxidative Stress in Angiotensin II‐ and Salt‐Induced Hypertensive Model Rats

Benzbromarone Attenuates Oxidative Stress in Angiotensin II‐ and Salt‐Induced Hypertensive Model Rats

Ramipril and haloperidol as promising approaches in managing rheumatoid arthritis in rats

The Characteristics and Roles of Advanced Oxidation Protein Products in Atherosclerosis

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