Effect of Tectona grandis on phenylhydrazine-induced anaemia in rats

Diallo, Aboudoulatif; Gbéassor, Messanvi; Vovor, A.; Eklu-Gadégbéku, Kwashie; Aklikokou, Kodjo; Agbonon, Amégnona; Abena, Ange Antoine; Souza, Comla de; Akpagana, Koffi

doi:10.1016/j.fitote.2008.02.005

Cited by 81 publications

(72 citation statements)

References 2 publications

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“…The evaluation of the haematological parameters is very important in toxicological studies. The hematopoietic system is a favorite target of toxic substances, and consequently an important parameter of humans' or animals' physiology (Oslon et al, 2000;Diallo et al, 2008). In our study P. pinnata has decreased significantly (p <0.05) some haematological parameters (MCV, MHC) and has increased the number of platelets and WBC.…”

Section: Subchronic Toxicity Testsupporting

confidence: 56%

Repeated toxicological study and cardiotoxicity of hydroalcoholic root extract of Paullinia pinnata L (Sapindaceae).

Mariame¹,

Diallo²,

Povi³

et al. 2016

J App Pharm Sci

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Paullinia pinnata L. is a plant widely used in African traditional medicine especially in the treatment of erectile dysfunction. This study aims to evaluate the cardiotoxicity of 50% hydroalcoholic extract of the roots of P. pinnata. The result of the acute toxicity test has shown a LD50 greater than 5000 mg/kg. During the 28 days subchronic administration, P. pinnata has increased significantly the relative weight of kidney. P. pinnata has induced also a microcytosis and an isolated hypochromia. Renal injuries were observed with doses of 400 mg/kg and 800 mg/kg; and are noted by the increase in blood urea, creatinine, potassium and chlorine. Cardiac disorders characterized by the increase of creatinine phosphokinase with P. pinnata at 800 mg/kg has been noted; as well as cholestasis, characterized by an increase in the ALP at 200, 400 and 800 mg/kg. The study conducted on the isolated auricle of guinea pigs, has shown that P. pinnata, at increasing concentrations (0.5 to 2.5 mg/mL) has caused an increase in the force of contraction (positive inotropic effect) and simultaneously a decrease in heart rate (negative chronotropic effect). The positive inotropic effect observed could justify the traditional use of this plant as an aphrodisiac.

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Section: Subchronic Toxicity Testsupporting

confidence: 56%

Repeated toxicological study and cardiotoxicity of hydroalcoholic root extract of Paullinia pinnata L (Sapindaceae).

Mariame¹,

Diallo²,

Povi³

et al. 2016

J App Pharm Sci

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show abstract

“…15,16 Anemia was considered to be induced when red blood cell (RBC) level as well as hemoglobin concentration of the blood reduced by about 30%.…”

Section: Induction Of Experimental Anemiamentioning

confidence: 99%

Protective Effects of Beetroot Extract against Phenyl Hydrazine Induced Anemia in Rats

Jaiswal¹,

Ganeshpurkar²,

Awasthi³

et al. 2014

Phcog J.

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Background: Anemia can be regarded as one of the oldest blood malformation known over a century. Megaloblastic anemia arises due to curtailed formation of erythrocytes, which leads to formation of a large number of underdeveloped erythrocytes. Proper nutritional supplementation may be useful in such condition. Beta vulgaris or beetroot is one of the important vegetables consumed worldwide. The aim of the present work was to evaluate anti-anemic potential of beetroot. Methods: Beetroot was extracted with ethanol. Phytochemical and phytoanalytical studies were performed on extract. Anemia was induced by phenyl-hydrazine. Animals were treated with extract throughout the study for 24 days. The red blood cell (RBC) number and hemoglobin concentration were determined every 3 days for 24 days. Results: Extract was found to be rich in folic acid, ascorbic acid, and iron. Following the induction of anemia, the number of erythrocytes and the hemoglobin concentration decreased by 62.51% and 69.64%, respectively. Administration of standard hematinic preparation and extract (200 mg/kg) resulted in signifi cant increase (P < 0.001; P < 0.01) in the number of RBCs as well as hemoglobin concentration when compared to the untreated phenyl hydrazine-induced anemic rats. Conclusion: Extract effectively raised the level of hemoglobin and erythrocyte count at dose 200 mg/kg. Vitamin and minerals found in beetroot are most likely active ingredients responsible for its hematinic effects. Still, methodical studies are obligatory to derive its effects on humans.

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“…and Arthrinium phaeospermum, the cause of wood decay [22,23] and also inhibited sporulation of Alternaria cajani and Helminthosporium species [24]. A number of pharmacological properties such as urinary discharge, bronchitis, cold and headache, in scabies, used as a laxative and sedative, as duretic, anti-diabetic, analgesic and anti-inflammatory etc, of this plant have been reported [25][26][27][28]. Various phytochemicals namely Juglone (5-Hydroxy-1,4-naphthalenedione) with anti-microbial activity [29], betulin [2-Hydroxy-3-(3-methylbut-2-enyl)-naphthalene-1,4-dione] aldehyde with anti-tumor activity [30] and lapachol [2-Hydroxy-3-(3-methylbut-2-enyl)-naphthalene-1,4-dione] with anti-ulcerogenic activity [31] have been isolated from Tectona grandis.…”

Section: Discussionmentioning

confidence: 99%

Cuticular Wax of Tectona grandis L. Leaves – A Resistance Marker against Plant Pathogens

Biswas¹,

Chakraborty²,

Bhowmik³

2017

Biochem Anal Biochem

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The leaf surface of higher plants is composed of varied profile of hydrocarbons which play a vital role in chemical recognition and potentially involved in plant-pathogen interactions and communication with nature. There is little evidence to the direction that plant cuticle play a major factor in plant defense against pathogens besides imparting physical barrier to the plant. Teak (Tectona grandis. L) is one such tree found with diverse geographical distribution. In the present work, our objective was to study the cuticular composition of the fresh leaves of teak which is responsible for its wide adaptation and its antimicrobial activity. Cuticular compounds from the hexane fraction of the teak leaves were isolated, purified and spectral analyses revealed a long chain unbranched heneicosane (C 21 ) with a mol. wt. of 296. This saturated hydrocarbon forms a continuous layer on the leaf surfaces which act as physical barrier to the micro-organisms and also possesses a strong defensing activity against a number of pathogens which implies its role in defensive mechanisms of the plant. The antifungal activity of heneicosane on each of the microbial species was statistically significant at P≤0.001 level. Its abundant recovery from teak leaves may justify its putative role as a resistance marker.

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Effect of Tectona grandis on phenylhydrazine-induced anaemia in rats

Cited by 81 publications

References 2 publications

Repeated toxicological study and cardiotoxicity of hydroalcoholic root extract of Paullinia pinnata L (Sapindaceae).

Repeated toxicological study and cardiotoxicity of hydroalcoholic root extract of Paullinia pinnata L (Sapindaceae).

Protective Effects of Beetroot Extract against Phenyl Hydrazine Induced Anemia in Rats

Cuticular Wax of Tectona grandis L. Leaves – A Resistance Marker against Plant Pathogens

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