Effect of taurine in chronic alcoholic patients

Abstract

A study was undertaken to investigate the dietary effect of taurine in chronic alcoholic patients. The 30 chronic alcoholic patients with 2 to 5 times greater than normal activities of aspartate transaminase (AST) or alanine transaminase (ALT) were selected and equally divided into taurine and control groups. In the taurine group, each patient took 6 g taurine per day, divided into 3 doses, for three months, and then stopped treatment for 1 month. In the control group, patients took a placebo without taurine for 4 months. It was found that the AST and ALT activities and levels of cholesterol, triglyceride (TG), bilirubin, and thiobarbituric acid reactive substances (TBARS) of serum plasma in the taurine group were all decreased, but increased alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) activities and serum vitamins concentrations. Except for the level of TG, all were significantly different after taking taurine for 2 or 3 months. It indicated that taurine plays an important role in the properties of antioxidation and has some improvement on the liver tests of chronic alcoholic patients.

Protective effects of Cholestin on ethanol induced oxidative stress in rats

“…Hepatic ADH activity was calculated by taking the extinction coefficient of NADH to be 6.22 × 10 L µmol −1 cm −1 . One unit of ADH was expressed as the amount of enzyme that produced 1 mol NADH min −1 at 25 °C …”

“…Hepatic ADH activity was calculated by taking the extinction coefficient of NADH to be 6.22 × 10 3 L μmol −1 cm −1 . One unit of ADH was expressed as the amount of enzyme that produced 1 mol NADH min −1 at 25 ∘ C. 26 For measurement of ALDH activity, two reaction tubes were prepared. One contained 100 μL of liver homogenate and 1 mL of 50 mmol L −1 sodium pyrophosphate buffer (pH 8.8) containing 1 mmol L −1 NAD + , 0.2 mmol L −1 4-methylpyrazole, 1 mmol L −1 MgCl 2 , 2μmol L −1 rotenone and 10 mL L −1 Triton X-100.…”

Oyster broth concentrate and its major component taurine alleviate acute alcohol‐induced liver damage

“…In addition, dietary taurine helps to reduce the liver inflammation and ER stress induced by high dietary carbohydrate intake (Zhang et al., 2021). Taurine administration also decreases the activity of aspartate transaminase (AST) and alanine transaminase (ALT), and increases that of ADH and ALDH in chronic alcoholic patients (Hsieh et al., 2014). Taurine shows beneficial effects on liver disease caused by chronic alcohol consumption in human and animal models (Hsieh et al., 2014; Song et al., 2021).…”

“…Taurine administration also decreases the activity of aspartate transaminase (AST) and alanine transaminase (ALT), and increases that of ADH and ALDH in chronic alcoholic patients (Hsieh et al., 2014). Taurine shows beneficial effects on liver disease caused by chronic alcohol consumption in human and animal models (Hsieh et al., 2014; Song et al., 2021). This study was performed to determine whether OBC rich in taurine had a hepatoprotective effect in a single‐EtOH‐binge mouse model.…”

Taurine mitigates the development of pulmonary inflammation, oxidative stress, and histopathological alterations in a rat model of bile duct ligation

“…Although the precise mechanism(s) of cholestasis-induced lung injury is far from clear, several studies noted the role of oxidative stress in this complication (Aruoma et al 1988;Cozzi et al 1995;Gürer et al 2001;Pushpakiran et al 2004;Acharya and Lau-Cam 2013;Hsieh et al 2014;Abdel-Moneim et al 2015;Alhumaidha et al 2015). In this context, severe biomembranes degradation (lipid peroxidation) and decreased cellular antioxidant capacity have been reported in the lung tissue in experimental models of cholestasis/cirrhosis (Salatti Ferrari et al 2012;Shikata et al 2014).…”