Effect of Taurine and Coenzyme Q10 in Patients with Acute Myocardial Infarction

Pharmacokinetics of Oral Taurine in Healthy Volunteers

“…Protective effects of taurine against arteriosclerosis [5], lung injury by oxidant gases [6], deleterious effects of various drugs such as tauromustine, an antitumor agent, [7], hepatotoxicity of sulfolithocholate [8], and its promotion of the recovery of leukocytes in irradiated rats [9] have already been studied on animals. The therapeutic effects of taurine on epilepsy [10], ischemia [11], obesity [12], diabetes [13], hypertension [14], Congestive heart failure [15], noxious effect of smoking [16], toxicity of methotrexate [17] myocardial infarction [18], alcoholic craving [19], and neurodegeneration in elderly [20] have also been reported. Taurine may protect membranes by detoxification of destructive compounds and/or by directly preventing alterations in membrane permeability [21].…”

New Developments in Coenzyme Q10 Research Contributed by A Single Group. Editorial

“…Effect of hydrosoluble CoQ10 causing a decline in insulin levels in hypertensive patients with coronary artery disease and reduction in serum concentration of lipoprotein(a) among acute myocardial infarction (AMI) patients were also observed for the first time by Singh et al in 1999 [22,23]. In view of these beneficial effects of CoQ10 on vascular disease risk [24][25][26][27], Singh et al demonstrated for the first time in rabbits that CoQ10 can inhibit atherosclerosis and modulate the quality and chemical composition of atheroma [25]. This group also administered CoQ10 in other CVDs in conjunction with taurine [26,27].…”

“…In view of these beneficial effects of CoQ10 on vascular disease risk [24][25][26][27], Singh et al demonstrated for the first time in rabbits that CoQ10 can inhibit atherosclerosis and modulate the quality and chemical composition of atheroma [25]. This group also administered CoQ10 in other CVDs in conjunction with taurine [26,27].…”

Effect of tavamin on the content of free amino acids in rat heart under alcohol withdrawal syndrome conditions

“…The administration of taurine produced a cardioprotective action on experimental models with cardiomyopathy and chronic cardiac insufficiency [4]. Clinical investigations also showed the ability of taurine to improve cardiac function in myocardial infarction and chronic cardiac insufficiency [2,5]. Forming conjugates with bile acids, taurine decreased the level of cholesterol in animals kept on an atherogenic diet [6].…”