Effect of Synthetic Organoselenium Drug on the Degree of Pathological Changes in the Organs of White Mice Immunized with Tularemia and Brucellosis Vaccines

Yurieva, Olga; Дубровина, В. И.; Потапов, В. А.; Мусалов, М. В.; Старовойтова, Т. П.; Иванова, Т. А.; Gromova, Arina; Шкаруба, Т. Т.; Балахонов, С. В.

doi:10.1007/s10517-019-04648-0

Cited by 16 publications

(21 citation statements)

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“…results, 2,6-dipyridiumyl-9-selenabicyclo[3.3.1]nonane dibromide was proposed as a promising drug for metabolic correction in the vaccination process [69].…”

Section: 1]nonanementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…We studied nucleophilic substitution reaction of bromine in compound 2 by pyridine [ 69 , 70 ]. Dipiridinium salt, 2,6-dipyridiumyl-9-selenabicyclo[3.3.1]nonane dibromide, was obtained in near quantitative yield [ 69 , 70 ]. The biological activity of this compound as a medicine for metabolic correction in the vaccination process and its effect on immunogenesis were studied [ 69 ].…”

Section: Introductionmentioning

confidence: 99%

“…Dipiridinium salt, 2,6-dipyridiumyl-9-selenabicyclo[3.3.1]nonane dibromide, was obtained in near quantitative yield [ 69 , 70 ]. The biological activity of this compound as a medicine for metabolic correction in the vaccination process and its effect on immunogenesis were studied [ 69 ]. It was found that this compound considerably diminished the pathological effect caused by the action of the tularemia vaccine in experimental animals and significantly reduced the reactogenicity of the brucellosis vaccine.…”

Section: Introductionmentioning

confidence: 99%

“…It was found that this compound considerably diminished the pathological effect caused by the action of the tularemia vaccine in experimental animals and significantly reduced the reactogenicity of the brucellosis vaccine. Based on these results, 2,6-dipyridiumyl-9-selenabicyclo[3.3.1]nonane dibromide was proposed as a promising drug for metabolic correction in the vaccination process [ 69 ].…”

Section: Introductionmentioning

confidence: 99%

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Efficient Synthesis of a New Family of 2,6-Disulfanyl-9-Selenabicyclo[3.3.1]Nonanes

2021

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The efficient synthesis of a new family of 2,6-disulfanyl-9-selenabicyclo[3.3.1]nonanes in high yields has been developed based on 9-selenabicyclo[3.3.1]nonane-2,6-dithiolate anion generated from bis-isothiouronium salt of 2,6-dibromo-9-selenabicyclo[3.3.1]nonane. The derivatives of 2,6-disulfanyl-9-selenabicyclo[3.3.1]nonane containing alkyl, allyl and benzyl moieties have been prepared in 90–99% yields by nucleophilic substitution of 9-selenabicyclo[3.3.1]nonane-2,6-dithiolate anion with alkyl, allyl and benzyl halides. The reaction of nucleophilic addition of 9-selenabicyclo[3.3.1]nonane-2,6-dithiolate anion to alkyl propiolates afforded 2,6-di(vinylsulfanyl)-9-selenabicyclo[3.3.1]nonanes. The conditions for regio- and stereoselective addition of 9-selenabicyclo[3.3.1]nonane-2,6-dithiolate anion to a triple bond of alkyl propiolates have been found. To date, not a single representative of 2,6-disulfanyl-9-selenabicyclo[3.3.1]nonanes has been described in the literature.

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“…results, 2,6-dipyridiumyl-9-selenabicyclo[3.3.1]nonane dibromide was proposed as a promising drug for metabolic correction in the vaccination process [69].…”

Section: 1]nonanementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Efficient Synthesis of a New Family of 2,6-Disulfanyl-9-Selenabicyclo[3.3.1]Nonanes

2021

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Immunotropic Properties of an Experimental Synthetic Selenium-Organic Compound

et al. 2020

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Effect of a Synthetic Organoselenium Compound on Post-Vaccination Immunopoiesis in the Red Bone Marrow and Cell Composition of Peripheral Blood of White Mice Vaccinated with Yersinia pestis EV

et al. 2021

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We studied the effect of an experimental synthetic organoselenium compound 2,6-dipyridinium-9-selenabicyclo[3.3.1]nonane dibromide (974zh) on the cell composition of the red bone marrow and peripheral blood in white mice. The study drug co-administered with Yersinia pestis EV vaccine strain (10 3 CFU) potentiated maturation and migration of mature neutrophils from the bone marrow into the circulation. Reducing the dose of the live vaccine and the anti-inflammatory properties of the study drug made it possible to reduce the allergic reaction during the vaccination process.

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Effect of Synthetic Organoselenium Drug on the Degree of Pathological Changes in the Organs of White Mice Immunized with Tularemia and Brucellosis Vaccines

Cited by 16 publications

References 2 publications

Efficient Synthesis of a New Family of 2,6-Disulfanyl-9-Selenabicyclo[3.3.1]Nonanes

Efficient Synthesis of a New Family of 2,6-Disulfanyl-9-Selenabicyclo[3.3.1]Nonanes

Immunotropic Properties of an Experimental Synthetic Selenium-Organic Compound

Effect of a Synthetic Organoselenium Compound on Post-Vaccination Immunopoiesis in the Red Bone Marrow and Cell Composition of Peripheral Blood of White Mice Vaccinated with Yersinia pestis EV

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