Effect of Synthesis Technique and Carbonate Content on the Crystallinity and Morphology of Carbonated Hydroxyapatite

Kee, Chia Ching; Ismail, Hanafi; Noor, Ahmad Fauzi Mohd

doi:10.1016/j.jmst.2013.05.016

Cited by 48 publications

(30 citation statements)

References 32 publications

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“…HPO 22 at 876, 1417 cm 21 , respectively. 6,8,[11][12][13][14][15] FT-IR spectra and XRD patterns of the powders milled in ethanol revealed the remaining of CaCO 3 and CaHPO 4 Á2H 2 O. This shows that rotation speed and time used in this study have not effected on phase transformation.…”

Section: Resultsmentioning

confidence: 66%

“…

{HPO}_{4}^{2 -}

, OH − ,

{PO}_{4}^{3 -}

, and

{CO}_{3}^{2 -}

are the functional groups corresponding to CaHPO 4 ·2H 2 O and CaCO 3 , respectively. Characteristic peaks of CaHPO 4 ·2H 2 O and CaCO 3 correspond to

{PO}_{4}^{3 -}

at 528, 562, and 1069–1129 cm −1 , OH − at 3272–3478 cm −1 ,

{HPO}_{4}^{3 -}

at 876 cm −1 , and H 2 O at 712 and 1641 cm −1 ,

{CO}_{3}^{2 -}

at 876, 1417 cm −1 , respectively . FT‐IR spectra and XRD patterns of the powders milled in ethanol revealed the remaining of CaCO 3 and CaHPO 4 ·2H 2 O.…”

Section: Resultsmentioning

confidence: 99%

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Hydroxyapatite nanoparticles formed under a wet mechanochemical method

Kosachan

Jaroenworaluck

Jiemsirilers

et al. 2015

J. Biomed. Mater. Res.

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Hydroxyapatite (HA) nanoparticles were synthesized using a wet mechanochemical method without a calcination process. Dicalcium phosphate dihydrate (CaHPO ·2H O) and calcium carbonate (CaCO ) were mixed and milled in a planary mill using ethanol or water as liquid media in the two different synthesized routes. Effects of rotation speed and milling time on the final products formed have been studied. Experimental results showed that HA phase having a characteristic of low crystallinity could be formed under the synthesis route using water. The original phases of both starting chemicals were remained without HA formation in the synthesis route using ethanol. Particle size and morphology of HA nanoparticles were obviously depended on optimum conditions of rotation speed and milling time. Differences on phase formation in both synthesized routes have been considered and discussed based on occurring chemical reaction possibilities. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 679-688, 2017.

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Section: Resultsmentioning

confidence: 66%

“…

{HPO}_{4}^{2 -}

, OH − ,

{PO}_{4}^{3 -}

, and

{CO}_{3}^{2 -}

are the functional groups corresponding to CaHPO 4 ·2H 2 O and CaCO 3 , respectively. Characteristic peaks of CaHPO 4 ·2H 2 O and CaCO 3 correspond to

{PO}_{4}^{3 -}

at 528, 562, and 1069–1129 cm −1 , OH − at 3272–3478 cm −1 ,

{HPO}_{4}^{3 -}

at 876 cm −1 , and H 2 O at 712 and 1641 cm −1 ,

{CO}_{3}^{2 -}

at 876, 1417 cm −1 , respectively . FT‐IR spectra and XRD patterns of the powders milled in ethanol revealed the remaining of CaCO 3 and CaHPO 4 ·2H 2 O.…”

Section: Resultsmentioning

confidence: 99%

Hydroxyapatite nanoparticles formed under a wet mechanochemical method

Kosachan

Jaroenworaluck

Jiemsirilers

et al. 2015

J. Biomed. Mater. Res.

View full text Add to dashboard Cite

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“…[6][7][8][9] The biological apatites are uniquely similar in that they all comprise carbonate (CO 3 ) in varying amounts of 2-8 wt %, preferentially substituting the PO 4 site (B-type) compared with OH (A-type) ions in the apatite lattice. [9][10][11][12][13] The composition of CO 3 depends on bone age, site, sex, and health of the individual. 8,14,15 The beneficial impact of CO 3 substitution into PO 4 and/ or OH site in HA structure has been reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

Development of multisubstituted hydroxyapatite nanopowders as biomedical materials for bone tissue engineering applications

Ismail

Wimpenny

Bretcanu

et al. 2017

J Biomedical Materials Res

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Ionic substitutions have been proposed as a tool to control the functional behavior of synthetic hydroxyapatite (HA), particularly for Bone Tissue Engineering (BTE) applications. The effect of simultaneous substitution of different levels of carbonate (CO 3 ) and silicon (Si) ions in the HA lattice was investigated. Furthermore, human bone marrow-derived mesenchymal stem cells (hMSCs) were cultured on multi-substituted HA (SiCHA) to determine if biomimetic chemical compositions were osteoconductive. Of the four different compositions investigates, SiCHA-1 (0.58wt% Si) and SiCHA-2 (0.45wt% Si) showed missing bands for CO 3 and Si using FTIR analysis, indicating competition for occupation of the phosphate site in the HA lattice. 500°C was considered the most favourable calcination temperature as: (i) the powders produced possessed a similar amount of CO 3 (2-8wt%) and Si (<1.0wt%) as present in native bone; and (ii) there was a minimal loss of CO 3 and Si from the HA structure to the surroundings during calcination. Higher Si content in SiCHA-1 led to lower cell viability and at most hindered proliferation, but no toxicity effect occurred.While, lower Si content in SiCHA-2 showed the highest ALP/DNA ratio after 21 days culture with hMSCs, indicating that the powder may stimulate osteogenic behaviour to a greater extent than other powders.

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“…Similarly, other studies have also reported that b-TCP could be detected as an unstable minor phase when CHA was heated between 600 and 800°C [46,47]. This lowtemperature phase transition could be related to the fact that CHA was less crystalline than the stoichiometric HA [48].…”

Section: Discussionmentioning

confidence: 63%

Microwave rapid conversion of sol–gel-derived hydroxyapatite into β-tricalcium phosphate

Hassan

Mahmoud

El-Fattah

et al. 2015

J Sol-Gel Sci Technol

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Calcium phosphate-based biomaterials are of great interest due to their use in various biomedical applications. Current preparation methods of b-tricalcium phosphate (b-TCP) require the processing of calcium phosphate precursors at high temperatures for long periods. Sol-gel-derived calcium-deficient carbonated hydroxyapatite (CHA) samples were synthesized and then aged at different times (24 and 90 h), while other freshly prepared samples were subjected to microwave (MW) radiation for 10 min in order to prepare b-TCP. All samples were calcined (at 750°C) and then were characterized using scanning electron microscopy, Fourier transform infrared spectroscopy and X-ray diffraction. The 24-h-aged samples showed complete degradation into b-TCP and calcium pyrophosphate (CPP) phases. However, only b-TCP phase was detected in the 90-h-aged samples. Furthermore, b-TCP as the major phase was also obtained in the 10-min MW-treated unaged samples. The aging of sol-gelderived CHA samples for 90 h had a positive effect on the conversion of CHA into b-TCP phase. Furthermore, the MW treatment of the unaged CHA samples enhanced its total conversion into b-TCP in shorter time which could be attributed to the MW irradiation-induced effect on the CHA structure. Graphical Abstract Sol Gel SynthesisCarbonated Hydroxyapatite (CHA) Pure β-Tricalcium Phosphate (major phase) Aging for 90 Hours + Calcination at 750 o C Microwaves for 10 minutes + Calcination at 750 o C

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Effect of Synthesis Technique and Carbonate Content on the Crystallinity and Morphology of Carbonated Hydroxyapatite

Cited by 48 publications

References 32 publications

Hydroxyapatite nanoparticles formed under a wet mechanochemical method

Hydroxyapatite nanoparticles formed under a wet mechanochemical method

Development of multisubstituted hydroxyapatite nanopowders as biomedical materials for bone tissue engineering applications

Microwave rapid conversion of sol–gel-derived hydroxyapatite into β-tricalcium phosphate

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