Effect of sympathetic denervation on the 5-hydroxytryptamine levels of the submaxillary glands of rats

Klingman, Gerda I.; Klingman, Jack D.

doi:10.1016/0006-2952(69)90310-4

Cited by 6 publications

(4 citation statements)

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“…I n several earlier studies, it was reported that avulsion of the superior cervical ganglion is followed by a significant reduction of the biogenic amines noradrcnaline, adrenaline and dopamine. Although, supported by earlier studies in adult glands (Klingman & Klingman 1969), the present results indicating that neonatal avulsion of the superior cervical ganglion caused an increase in 5-HT and 5-HIAA are somewhat surprising.…”

Section: Discussionsupporting

confidence: 76%

“…T h e effect of 5-HT is in many ways similar to that described for the /jl-adrenoceptor agonists, which are potent inducers of exocytotic amylase release, whereas almost no effect is seen on the potassium efflux (Carlsiio et al 1981, Danielsson 81 Sehlin 1983. T h e present results give no further information regarding the existence of more than one 5-HT receptor subtype (Rerridge & Heslop 1981, Peroutka & Snyder 1983, Roth & Chuang 1987). I n several earlier studies, it was reported that avulsion of the superior cervical ganglion is followed by a significant reduction of the biogenic amines noradrcnaline, adrenaline and dopamine.…”

Section: Discussioncontrasting

confidence: 57%

“…Klingman & Klingman (1969) suggested that the absence of sympathetic innervation by itself is directly responsible for the increase in 5-HT levels in salivary glands. Obviously, the present results indicate that there exist no 5-HT nerves innervating parotid tissue from the superior cervical ganglion, i.e.…”

Section: Discussionmentioning

confidence: 99%

“…1973, Carlsoo et al 1974) and fluid secretion from salivary glands of the blowfly (Berridge & Patel 1968). T h e existence of at least two distinct populations of 5-HT receptors in salivary tissues as well as in other tissues has been suggested (Berridge & Heslop 1981, Peroutka & Snyder 1983, Roth & Chuang 1987. Although these results suggest a specific role of 5-HT in salivary glands, the serotoninergic system has attracted less interest as compared with the sympa-Correspondencc ; Dr Roger IIenriksson, Department of Histology and Cell Biology, University of Umei, S-90185 Umei, Sweden.…”

mentioning

confidence: 99%

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Secretory effects of 5‐hydroxytryptamine following neonatal sympathectomy in rat parotid gland

Henriksson

Sundström

Danielsson

et al. 1990

Acta Physiologica Scandinavica

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Unilateral sympathetic denervation of rat parotid glands was performed within 4 h after birth. Nine weeks later the glands were used for in-vitro studies of amylase secretion, and 86Rb+ was used as a marker for potassium efflux. The non-denervated contralateral glands served as controls. The tissue concentrations of 5-hydroxytryptamine and its metabolite 5-hydroxyindole acetic acid were also measured. 5-Hydroxytryptamine caused a significant dose-dependent increase in amylase secretion, which was inhibited by methysergide. There was no difference between controls and denervated glands. 5-Hydroxytryptamine was without effect on potassium efflux from either denervated or control glands. The sympathectomy caused increased levels of 5-hydroxytryptamine and 5-hydroxyindole acetic acid as compared with contralateral controls. The results suggest that 5-hydroxytryptamine influences the two main secretory processes in rat parotid gland differently. A significant amylase discharge was seen following 5-hydroxytryptamine stimulation, whereas no effect was seen on 86Rb+ efflux. Although it is also proposed that there are no 5-hydroxytryptamine-associated nerves in the superior cervical ganglion innervating parotid tissue, it seems that there is a complex connection between the sympathetic pathway and the serotoninergic system.

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Section: Discussionsupporting

confidence: 76%

Section: Discussioncontrasting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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