Effect of sweet fennel seed extract capsule on knee pain in women with knee osteoarthritis

Alazadeh, Marzieh; Azadbakht, Mohammad; Niksolat, Fatemeh; Asgarirad, Hossein; Moosazadeh, Mahmood; Ahmadi, Amirhossein

doi:10.1016/j.ctcp.2020.101219

Cited by 6 publications

(2 citation statements)

References 21 publications

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“…Marzieh Alazadeh et al ( Alazadeh et al, 2020 ) conducted an RCTs to obsrerve the effect of Foeniculum vulgare Mill [ Apiaceae ] (commonly known as Fennel) seed extract capsules in relieving knee OA pain. Sixty-six 66) patients were randomized to the sweet fennel seed extract capsule group and the placebo group.…”

Section: Introductionmentioning

confidence: 99%

Safety Evaluation of Natural Drugs in Chronic Skeletal Disorders: A Literature Review of Clinical Trials in the Past 20 years

et al. 2022

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Chronic skeletal disorders (CSDs), including degenerative diseases such as osteoporosis (OP) and autoimmune disorders, have become a leading cause of disability in an ageing society, with natural drugs being indispensable therapeutic options. The clinical safety evaluation (CSE) of natural drugs in CSDs has been given priority and has been intensively studied. To provide fundamental evidence for the clinical application of natural drugs in the elderly population, clinical studies of natural drugs in CSDs included in this review were selected from CNKI, Web of Science, PubMed, Science Direct and Google Scholar since 2001. Seventeen randomized controlled trials (RCTs) met our inclusion criteria: four articles were on OP, seven on osteoarthritis (OA), four on rheumatoid arthritis (RA) and two on gout. Common natural drugs used for the treatment of OP include Epimedium brevicornu Maxim [Berberidaceae], Dipsacus asper Wall ex DC [Caprifoliaceae] root, and Phalaenopsis cornu-cervi (Breda) Blume & Rchb. f[ Orchidaceae], which have been linked to several mild adverse reactions, such as skin rash, gastric dysfunction, abnormal urine, constipation and irritability. The safety of Hedera helix L [Araliaceae] extract, Boswellia serrata Roxb [Burseraceae] extract and extract from perna canaliculus was evaluated in OA and upper abdominal pain, and unstable movements were obsrerved as major side effects. Adverse events, including pneumonia, vomiting, diarrhoea and upper respiratory tract infection, were reported when RA was treated with Tripterygium wilfordii, Hook. F [Celastraceae][TwHF] polyglycosides and quercetin (Capsella bursa-pastoris (L.) Medik [Brassicaceae]). The present review aimed to summarize the CSE results of natural drugs in CSDs and could provide evidence-based information for clinicians.

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Section: Introductionmentioning

confidence: 99%

Safety Evaluation of Natural Drugs in Chronic Skeletal Disorders: A Literature Review of Clinical Trials in the Past 20 years

et al. 2022

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“…Recent study reported that 300 μg/μl FS ethanolic extract inhibited Influenza virus H5N1 by 82.8% [89]. Moreover, Alazadeh et al, showed that oral administration of FS extract in capsular form ameliorated knee ostroarthritis [90]. In addition, methanol extract of FS showed significant anticancer potential against liver cancer cell line Hepg-2 (IC50 = 27.96 μg/mL) and breast cancer cell line MCF-7 (IC50 = 15.78 μg/mL) [80].…”

Section: Fennelmentioning

confidence: 99%

Spices-Reservoir of Health Benefits

Sachdeva¹,

Kaushik²

2022

Natural Medicinal Plants

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Spices contribute to the quality, nutritive value, and flavor of food. Since ancient times, they hold a great medicinal value. Their antimicrobial, antiviral, antibacterial, anti-inflammatory, and other numerous properties have made them a potent source of therapeutic agents. Phytochemical analysis revealed presence of active constituents such as eugenol, curcumin, carotenoids in clove, turmeric, saffron respectively that explains the efficacious nature of these spices. Owing to their easy availability and consumption, it is advised to make spices daily part of our diet though in balanced amount as sometimes excess usage bear few consequences. Evaluating multiple benefits offered by these as immunity boosters especially in times of pandemic and incorporating them in our routine diet would improve disease management strategies. This chapter discusses the reservoir of activities exhibited by few spices along with the components responsible for these activities. Here, we also discussed their negative effects if at all.

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Prevention and treatment of inflammatory arthritis with traditional Chinese medicine: Underlying mechanisms based on cell and molecular targets

Lei

et al. 2023

Ageing Research Reviews

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Effect of sweet fennel seed extract capsule on knee pain in women with knee osteoarthritis

Cited by 6 publications

References 21 publications

Safety Evaluation of Natural Drugs in Chronic Skeletal Disorders: A Literature Review of Clinical Trials in the Past 20 years

Safety Evaluation of Natural Drugs in Chronic Skeletal Disorders: A Literature Review of Clinical Trials in the Past 20 years

Spices-Reservoir of Health Benefits

Prevention and treatment of inflammatory arthritis with traditional Chinese medicine: Underlying mechanisms based on cell and molecular targets

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