Effect of sustained pharmacologic vitamin E levels on incidence and severity of retinopathy of prematurity: A controlled clinical trial

Johnson, Lois; Quinn, Graham E.; Abbasi, Soraya; Otis, Chari; Goldstein, Donald J.; Sacks, Linda M.; Porat, Rachel; Fong, Elizabeth; Delivoria‐Papadopoulos, Maria; Peckham, George J.; Schaffer, David B.; Bowen, Frank W.

doi:10.1016/s0022-3476(89)80149-0

Cited by 87 publications

(50 citation statements)

References 56 publications

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“…The effect of vitamin E for the prophylaxis of retinopathy is still controversial [22]. Our study has shown that vitamin E has a favorable influence.…”

Section: Discussionmentioning

confidence: 67%

Risk Factors in Retinopathy of Prematurity

Seiberth

Linderkamp²

2000

Ophthalmologica

146

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Objective: To analyze risk factors in retinopathy of prematurity (ROP). Patients and Methods: Four hundred forty-seven surviving very-low-birth-weight infants (birth weight ≤1,500 g) were enrolled in a retrospective study. Clinical data underwent multivariate analysis using stepwise logistic forward regression. Results: For 402 of the babies a complete dataset of 38 possible risk factors was available. Multivariate analysis showed 10 factors to be independently significant variables. Low birth weight, low gestational age, artificial ventilation for more than 7 days, high volume of blood transfusion and surfactant therapy were risk factors associated with higher rates of ROP. Necrotizing enterocolitis, maternal pre-eclampsia, lung maturation by antepartum betamethasone application, vitamin E and phototherapy were accompanied by a lower incidence of ROP. Conclusions: This study confirms several risk factors recognized by previous statistical analysis. In addition, this study reveals maternal pre-eclampsia, which is associated with chronic intrauterine stress, as a statistically independent factor and as having an influence on the incidence of ROP.

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“…The effect of vitamin E for the prophylaxis of retinopathy is still controversial [22]. Our study has shown that vitamin E has a favorable influence.…”

Section: Discussionmentioning

confidence: 67%

Risk Factors in Retinopathy of Prematurity

Seiberth

Linderkamp²

2000

Ophthalmologica

146

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“…4 Several major controlled clinical trials of vitamin E therapy have produced inconsistent findings. 5,6 Inositol administration to preterm infants, however, has resulted in a lower incidence of ROP. 7 Inositol is a naturally occurring component of human milk and is not routinely added to infant formula.…”

Section: Original Articlementioning

confidence: 99%

Association of Human Milk Feedings With a Reduction in Retinopathy of Prematurity Among Very Low Birthweight Infants

et al. 2001

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“…Although a meta-analysis of 6 randomized trials administering vitamin E to preterm infants concluded that there was a 50% reduction in severe ROP by use of this antioxidant [23], the dose of vitamin E needed to protect infants from severe ROP was associated with significant increases in the risk of sepsis and necrotizing enterocolitis, which precluded widespread use of this therapy [24]. D -Penicillamine has also been suggested to lower ROP incidence in high-risk preterm infants [25].…”

Section: Discussionmentioning

confidence: 99%

Reduction of Retinopathy of Prematurity in Extremely Low Gestational Age Newborns Treated with Recombinant Human Cu/Zn Superoxide Dismutase

Parad

Allred²,

Rosenfeld³

et al. 2012

Neonatology

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Background: Reactive oxygen species have been implicated in the pathogenesis of retinopathy of prematurity (ROP). Extremely low gestational age (GA) newborns (ELGANs) have the highest risk of ROP and might benefit most from treatment with antioxidants. Objectives: To determine whether recombinant human Cu/Zn superoxide dismutase (rhSOD) decreases the incidence or severity of ROP in ELGANs. Methods: A previous multicenter trial of intratracheal rhSOD for prevention of bronchopulmonary dysplasia randomized 302 preterm infants to receive intratracheal rhSOD or placebo at birth and every 48 h for 1 month. An analysis of the incidence and severity of ROP was performed in ELGANs. Results: The risk of ROP increased with decreasing GA. Within the entire cohort, no significant differences in ROP were found in the placebo versus rhSOD groups. Subgroup analysis on infants born at <26 weeks (n = 72) revealed a 22% reduction in ROP from 85% (placebo) to 66% (rhSOD) (p = 0.06). In subjects born at <25 weeks (n = 24), ROP was reduced by 53% from 85% (placebo) to 40% (rhSOD) (p = 0.03). ROP severity above stage 2 was found in 42% of placebo-treated infants but only 25% of rhSOD-treated subjects with ROP. Conclusions: This post hoc analysis suggests that rhSOD reduces the risk of developing ROP in ELGANs, although further studies are required to confirm this observation.

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Effect of sustained pharmacologic vitamin E levels on incidence and severity of retinopathy of prematurity: A controlled clinical trial

Cited by 87 publications

References 56 publications

Risk Factors in Retinopathy of Prematurity

Risk Factors in Retinopathy of Prematurity

Association of Human Milk Feedings With a Reduction in Retinopathy of Prematurity Among Very Low Birthweight Infants

Reduction of Retinopathy of Prematurity in Extremely Low Gestational Age Newborns Treated with Recombinant Human Cu/Zn Superoxide Dismutase

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