Effect of surface roughness and calcium phosphate coating on the implant/bone response

Hayakawa, Tohru; Yoshinari, Masao; Nemoto, Kimiya; Wolke, Joop G.C.; Jansen, John A.

doi:10.1034/j.1600-0501.2000.011004296.x

Cited by 79 publications

(59 citation statements)

References 25 publications

(29 reference statements)

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“…8 Various animal studies have proved that CaP-coated implants show greater bone contact than non-coated implants. 9,10 In addition to surface quality, growth factors can also stimulate bone healing around implants. The effect of osteoinductive factors like bone morphogenetic proteins or transforming growth factor (TGF)-b has been a topic of various experiments.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Platelet-Rich Plasma on the Bone Healing around Calcium Phosphate?Coated and Non-coated Oral Implants in Trabecular Bone

Nikolidakis¹,

Dolder²,

Wolke³

et al. 2006

Tissue Engineering

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The effect of local application of autologous platelet-rich plasma (PRP) on bone healing in combination with the use of titanium implants with 2 different surface configurations was investigated. PRP fractions were obtained from venous blood sample of 6 goats and applied via gel preparation and subsequent installation in the implant site or via dipping of the implant in PRP liquid before insertion. Thirty-six implants (18 non-coated and 18 calcium phosphate (CaP) coated) were placed into the goat femoral condyles (trabecular bone). The animals were sacrificed at 6 weeks after implantation, and implants with surrounding tissue were processed for light microscopical evaluation. In addition to subjective description of the histological findings, histomorphometrical variables were also evaluated (the boneimplant contact and the bone mass adjacent to the implant). Significantly more interfacial bone-to-implant contact was observed for all 3 groups of CaP-coated implants and the titanium / liquid group (non-coated implant with PRP liquid) than for the other 2 non-coated titanium groups (with PRP gel or without PRP). The evaluation of the bone mass close to implant surface indicated that all the groups induced a significant increase of the bone mass except the PRP gel groups. On the basis of the observations, it was concluded that magnetron-sputtered CaP coatings can improve the integration of oral implants in trabecular bone. The additional use of PRP did not offer any significant effect on the bone response to the CaP-coated implants, whereas PRP in a liquid form showed a significant effect on bone apposition to roughened titanium implants during the early post-implantation healing phase.

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Section: Introductionmentioning

confidence: 99%

The Effect of Platelet-Rich Plasma on the Bone Healing around Calcium Phosphate?Coated and Non-coated Oral Implants in Trabecular Bone

Nikolidakis¹,

Dolder²,

Wolke³

et al. 2006

Tissue Engineering

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“…They placed these implants in rabbits and evaluated histologically and histomorphometrically. They found that the coating had a beneficial effect on the bone response to the healing phase at an early stage after implant placement 47) . Ong et al used the sputtering method to coat hydroxyapatite with thicknesses of 1.4 m onto implants.…”

Section: Osteocalcinmentioning

confidence: 99%

“…Titanium-bone osseointegration under the hydroxyapatite coating can be accelerated depending on the thickness of the coating 46,47) .…”

Section: Osteocalcinmentioning

confidence: 99%

The Effect of Implant Surfaces sputter-coated with Hydroxyapatite Target

Sakai

Okamura

Watazu

et al. 2013

J. Hard Tissue Biology.

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The aim of this study was to develop experimental titanium implants sputter-coated from a hydroxyapatite target and to evaluate peri-implant tissue responses in an animal experiment. The experimental implants were prepared from plastic rods, each of which was 1.6 mm in diameter and 7 mm in length. A thin titanium film was deposited onto the rods by DC magnetron sputtering. The surface of each rod was subsequently sputter-coated from a hydroxyapatite target by RF magnetron sputtering. The experimental implants were placed in the tibiae of 8-week-old male SD rats. Titanium-coated implants were placed as controls using the same method. Tissue samples were obtained 3, 5, 7, 10, 14, and 28 days after implant placement. Histological evaluation was performed using a light microscope, and the bone-implant contact ratios (BICs) were measured. Microstructural observations of implant-bone interfaces were made using a transmission electron microscope (TEM). Peri-implant osteoblastic activity was evaluated using samples obtained 5, 7, and 10 days after implant placement. Immunohistochemical evaluation of type I collagen, osteopontin, and osteocalcin was performed. Uniform smoothness of experimental implant surfaces was confirmed by scanning electron microscope(SEM) images. In the calcium phosphate layer, the compositional ratio of the experimental implant surface was Ca:P:O=1.0:0.79:2.8 based on the results of X-ray photoelectron spectroscopy(XPS). In the trabecular bone region, the BIC ratio was significantly higher in the experimental group than in the control group at 5, 7, 10, and 28 days after implant placement. Type I collagen, osteopontin, and osteocalcin immunostaining revealed that the experimental group tended to show positive results earlier than the control group. The results of this study suggest that surface treatment using a hydroxyapatite target and RF magnetron sputtering can enhance new bone formation during implant osseointegration.

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“…Before surgery, all implants were sterilized in an autoclave. Cylindrical Ti and Laser-Ti implants were implanted into the cortical bone defect of left and right tibiae or the trabecular bone defect of left and right femoral condyles as previously described 22,23) . Each rabbit received two implants: one each in the left and right tibiae.…”

Section: Implantation Procedures For Rabbit Tibia and Femoral Condylementioning

confidence: 99%

Bone and Gingival Connective Tissue Responses towards Nanosecond-Pulsed Laser-Treated Titanium Implants

Fukayo

Amemiya

Nakaoka

et al. 2016

J. Hard Tissue Biology.

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:The aim of this study was to evaluate bone and gingival connective tissue responses towards nanosecond-pulsed laser-treated titanium implants. A Nd:YVO 4 nanosecond-pulse laser with a defocus technique was used to modify the surfaces of two types of cylindrical titanium implants. One had a 3.5 mm diameter and 7.0 mm length ( 3.5 Ti) to assess rabbit bone responses; the other a 1.0 mm diameter and 4.5 mm length ( 1.0 Ti) to assess rat gingival connective tissue responses. Laser-treated titanium implants, a 3.5 Laser-Ti and 1.0 Laser-Ti, were obtained by defocus irradiation. Collagen immobilized 1.0Laser-Ti ( 1.0 Coll/Laser-Ti) implants were obtained by a tresyl chloride-activated method. Laser-Ti surfaces had micro-scale roughened oxide layers and parallel arranged grooves. Sa (average roughness) and Sdr (interfacial area ratio) values of the Laser-Ti were significantly higher than those of Ti (titanium) implants (p<0.05). The 3.5 implants were implanted into the bone defects of rabbits to evaluate bone responses and 1.0 implants were implanted into the extracted sockets of rat maxilla to evaluate gingival connective tissue responses. After implantation periods, the specimens were excised and non-decalcified thin sections prepared to evaluate histological responses. After 12 weeks of implantation in the rabbit experiments, bone-to-implant contact for the Laser-Ti implants was significantly higher than for the Ti in both tibia and femoral condyle (p<0.05). Improved attachment of gingival connective tissue to the implant surface was observed for Laser-Ti and Coll/Laser-Ti in the rat maxilla. Polarized light microscopy showed perpendicular rod-like attachments of gingival collagen fibers on the Laser-Ti and Coll/ Laser-Ti implant surfaces. Ti implants had no discernible attachments with gingival connective tissue along the implant surface. In conclusion, nanosecond-pulsed laser treatment with a defocus technique produced roughened titanium surfaces with parallel grooves and micro-roughened asperities. Laser treatment of implants resulted in improved bone responses and attachment of gingival connective tissue.

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Effect of surface roughness and calcium phosphate coating on the implant/bone response

Cited by 79 publications

References 25 publications

The Effect of Platelet-Rich Plasma on the Bone Healing around Calcium Phosphate?Coated and Non-coated Oral Implants in Trabecular Bone

The Effect of Platelet-Rich Plasma on the Bone Healing around Calcium Phosphate?Coated and Non-coated Oral Implants in Trabecular Bone

The Effect of Implant Surfaces sputter-coated with Hydroxyapatite Target

Bone and Gingival Connective Tissue Responses towards Nanosecond-Pulsed Laser-Treated Titanium Implants

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