The Effect of Platelet-Rich Plasma on the Bone Healing around Calcium Phosphate?Coated and Non-coated Oral Implants in Trabecular Bone

Abstract

The effect of local application of autologous platelet-rich plasma (PRP) on bone healing in combination with the use of titanium implants with 2 different surface configurations was investigated. PRP fractions were obtained from venous blood sample of 6 goats and applied via gel preparation and subsequent installation in the implant site or via dipping of the implant in PRP liquid before insertion. Thirty-six implants (18 non-coated and 18 calcium phosphate (CaP) coated) were placed into the goat femoral condyles (trabecular bone). The animals were sacrificed at 6 weeks after implantation, and implants with surrounding tissue were processed for light microscopical evaluation. In addition to subjective description of the histological findings, histomorphometrical variables were also evaluated (the boneimplant contact and the bone mass adjacent to the implant). Significantly more interfacial bone-to-implant contact was observed for all 3 groups of CaP-coated implants and the titanium / liquid group (non-coated implant with PRP liquid) than for the other 2 non-coated titanium groups (with PRP gel or without PRP). The evaluation of the bone mass close to implant surface indicated that all the groups induced a significant increase of the bone mass except the PRP gel groups. On the basis of the observations, it was concluded that magnetron-sputtered CaP coatings can improve the integration of oral implants in trabecular bone. The additional use of PRP did not offer any significant effect on the bone response to the CaP-coated implants, whereas PRP in a liquid form showed a significant effect on bone apposition to roughened titanium implants during the early post-implantation healing phase.

Short dental implants as compared to maxillary sinus augmentation procedure for the rehabilitation of edentulous posterior maxilla: Three‐year results of a randomized clinical study

“…28,46,47 Furthermore, a layer of liquid-PRP sprayed onto the implant surface before insertion showed a tendency to increase the bone apposition to roughened titanium implants during early healing phase. 48,49 All of these findings may therefore support the clinical use of PRP during oral bone regenerative procedures where differentiation and proliferation of bone cells at the site of surgery is required.…”

Dental Implant Surface Enhancement and Osseointegration

“…A clinical study in which 1391 implants were placed in 295 patients after bioactivating the surface with PRGF, stability and implant survival were evaluated, and it was reported that 99.6% of the implants treated with PRGF were well osseointegrated suggesting that the clinical use of this technique in oral implantology can improve the prognosis (Anitua, 2006). Animal studies in which platelet-rich plasma in liquid form was applied to the implant surface by dipping the implant in PRP prior to placement have demonstrated that PRP in a liquid form showed a tendency to increase bone apposition to roughened titanium implants (Nikolidakis et al, 2008, Nikolidakis et al, 2006. Nikolidakis et al (2006) investigated the effect of local application of autologous platelet-rich plasma (PRP) on bone healing in combination with the use of titanium implants with 2 different surface configurations -CaP coated and non-coated implants.…”

“…Animal studies in which platelet-rich plasma in liquid form was applied to the implant surface by dipping the implant in PRP prior to placement have demonstrated that PRP in a liquid form showed a tendency to increase bone apposition to roughened titanium implants (Nikolidakis et al, 2008, Nikolidakis et al, 2006. Nikolidakis et al (2006) investigated the effect of local application of autologous platelet-rich plasma (PRP) on bone healing in combination with the use of titanium implants with 2 different surface configurations -CaP coated and non-coated implants. PRP fractions were obtained from venous blood sample of 6 goats and applied via gel preparation and subsequent installation in the implant site or via dipping of the implant in PRP liquid before insertion.…”

Bone marrow mesenchymal stem cells, platelet-rich plasma and nanohydroxyapatite-type I collagen beads were integral parts of biomimetic bone substitutes for bone regeneration

“…PRP was harvested from blood for tissue regeneration because of the many factors within it that activate osteoid production, collagen synthesis and cell proliferation (Frechette et al, 2005;Uggeri et al, 2007). In addition, the fibrinogen in PRP gel gives it a fibril structure that, when mixed with thombin or calcium chloride, creates a plastic substance that easily moulds to fit a defect (Nikolidakis et al, 2006).…”