Effect of Surface Compositional Heterogeneities and Microphase Segregation of Fluorinated Amphiphilic Copolymers on Antifouling Performance

Abstract

In this paper, a series of fluorinated amphiphilic copolymers composed of 2-perfluorooctylethyl methacrylate (FMA) and 2-hydroxyethyl methacrylate (HEMA) monomers were prepared, and their surface properties and antifouling performance were investigated. Bovine serum albumin (BSA) and human plasma fibrinogen (HFg) were used as model proteins to study protein adsorption onto the fluorinated amphiphilic surfaces. All the fluorinated amphiphilic surfaces exhibit excellent resistant performance of protein adsorption measured by X-ray photoelectron spectroscopy (XPS). The surface compositional heterogeneities on the molecular scale play an important role in the antifouling properties. It was found that the copolymers exhibited better antifouling properties than the corresponding homopolymers did, when the percentage of hydrophilic hydroxyl groups is from 4% to 7% and the percentage of hydrophobic fluorinated moieties is from 4% to 14% on the surface. In addition, the protein molecular size scale and the pattern of microphase segregation domains on the surface strongly affect the protein adsorption behaviors. These results demonstrate the desirable protein-resistant performance from the fluorinated amphiphilic copolymers and provide deeper insight of the effect of surface compositional heterogeneity and microphase segregation on the protein adsorption behaviors.

Self-assembled monolayers of perfluoroalkylsilane on plasma-hydroxylated silicon substrates

“…The contributions of C 1s electrons from C * -N and C * H 2 -CF 2 groups at 286.0 eV ( E = 1.0 eV) were too close together to be resolved and therefore were summed together. The peak at 287.8 eV ( E = 2.8 eV) was attributed to C * -O, while the peak at 288.5 eV ( E = 3.5 eV) was assigned to carbonyl carbon (C * O), which in close agreement with previously reported values [20,53]. The signals with high binding energies were attributed to the C*F 2 -CH 2 at 290.8 eV ( E = 5.8 eV), C*F 2 -CF 2 and C*F 2 -CF 3 at 291.4 eV ( E = 6.4 eV), and terminal C*F 3 groups at 293.6 eV ( E = 8.6 eV), respectively.…”

“…The liquid phase method has been widely studied in the last decades, though some conditions (such as temperature, solvent polarity, viscosity and moisture content, etc.) are still needed to be optimized [9,[19][20][21], most of the self-assembly processes with organosilanes http://dx.doi.org/10.1016/j.apsusc.2015.05.073 0169-4332/© 2015 Elsevier B.V. All rights reserved. are performed at solution/solid interface.…”

Toward efficient water/oil separation material: Effect of copolymer composition on pH‐responsive wettability and separation performance

“…These peaks are clearly observed in Figures 7B-D and agreed with the related bonding energies of the functional group in the block copolymer as confirmed by previously works. 44,63,64 The composition proportion results shown in Table 2 indicate that the contents of the -CF, -CF 2 and -CF 3 groups at the topmost surface decrease with the decrease in bulk composition of the fluorinated moieties. Meanwhile, the surface contents of the -C5O group increase with the increase in PAA block length.…”

Preparation, surface wetting properties, and protein adsorption resistance of well‐defined amphiphilic fluorinated diblock copolymers

“…More recently, Zhao et al reported copolymer films which were prepared by amphiphilic random copolymers. It is found that these copolymers exhibited better antifouling properties for bovine serum albumin (BSA) and human plasma fibrinogen (HFg) than the corresponding homopolymers …”