Effect of Supranutritional Dosage Selenium in Neonatal Goat Kids on Productive Performance, Physicochemical Profiles in Meat, Selenium Levels in Tissues, and Histopathological Findings

Ortiz-Morales, Oscar; Ramírez-Bribiesca, J. Efrén; Bautista, Jorge Hernández; Hernández-Sánchez, David; Bárcena-Gama, J.R.; Trujillo, Elein Hernández; Díaz-Sánchez, Víctor; Fariña, Germán Isauro Garrido; López-Ojeda, José Carlos; Hernández-Rodríguez, Martha

doi:10.1007/s12011-022-03528-5

Cited by 2 publications

(1 citation statement)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pathomorfologically, it manifests with degeneration, paleness, fibrosis, necrosis and calcification in the heart muscle [2,3,4]. WMD is usually seen in kids (Capra aegagrus hircus), lambs (Ovis aries), calves (Bos taurus) and camels (Camelus) [5,6,7]. WMD shows a global incidence of around 1%.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of local expressions of acute phase proteins in white muscle disease in lambs by the immunohistochemical method

Karatas,

Akcakavak

2024

RC FCV-LUZ

View full text Add to dashboard Cite

White muscle disease (WMD) and/or nutritional muscular dystrophy is defined as a disease with a generally acute course that results in degeneration and necrosis of the heart muscle. In this study, it was aimed to reveal local tissue expressions of acute phase proteins such as C–reactive protein (CRP), Serum amyloid–A (SAA) and Haptoglobin (Hp) in lambs with WMD. The study material consisted of 27, one–six months old lamb heart tissues, 6 of which were healthy and 21 with WMD. The lambs were necropsied, and the relevant heart samples were taken into neutral formaldehyde. Afterwards, paraffin blocks were obtained by going through routine tissue follow–up processes. Sections were taken from paraffin blocks and stained with Hematoxylin–Eosin (H–E) and Immunohistochemical methods. Histopathologically, control groups exhibited normal histology. Hyaline degeneration, Zenker necrosis, calcification, inflammatory cell infiltration and an increase in connective tissue were detected in the heart tissues of lambs with WMD. Lambs with WMD had significantly increased CRP and SAA proteins compared to control (P<0.01). However, there was no difference between the groups in Hp (P>0.05). In conclusion, local tissue expressions of CRP, SAA and Hp in lambs with WMD were identified immunohistochemically for the first time. It is possible to say that CRP and SAA may play important roles in the pathophysiology of WMD and that CRP and SAA may provide more sensitive results in the diagnosis and prognosis of the disease.

show abstract