Effect of supplementation of vitamin C and E on oxidative stress in osteoporosis

Chavan, Sarita; More, Umesh; Mulgund, Shruti; Saxena, Vishal; Sontakke, Alka N.

doi:10.1007/bf02913324

Cited by 39 publications

(40 citation statements)

References 8 publications

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“…Conversely, Li and colleagues had found no any effect of vitamin E supplementation on these enzymes activities [Li et al 1996]. Chavan and colleagues observed a significant rise in their activities only in combination with vitamin C supplementation [Chavan et al 2007].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of vitamin E in knee osteoarthritis management of North Indian geriatric population

Bhattacharya¹,

Saxena²,

Gupta³

2011

Therapeutic Advances in Musculoskeletal

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Background: Osteoarthritis (OA) is the most common cause of chronic pain and disability in the elderly. It involves progressive destruction of articular cartilage as a consequence of various factors including augmented oxidative stress with advancing age which has not yet been controlled. It is conceivable that exogenous vitamin E supplementation ameliorates the modifiable indexes via regulation of free radical production and the consumption of antioxidant reserve. The objectives of the present study were to investigate the therapeutic effect of vitamin E supplementation in ameliorating the altered activity of antioxidant enzymes (superoxide dismutase, ceruloplasmin, glutathione peroxidase and catalase), erythrocyte malondialdehyde level (MDA, i.e. marker of lipid peroxidation) and markers of systemic inflammation (plasma C-reactive protein [CRP] and synovial fluid interleukin 6 [IL-6]) in osteoarthritic elderly. Methods: Antioxidant enzymes status, MDA, IL-6 and CRP levels were estimated by using standard methods in 40 healthy individuals (control group) and in 40 osteoarthritic patients aged 50-70 years before and after 3 months of vitamin E supplementation, i.e. group I (nonsupplemented) and group II (200 mg/day vitamin E supplemented). The obtained values were compared statistically by using Student's t-test. Results: Marked alteration in antioxidant enzymes, MDA and inflammatory markers were observed in group I (p < 0.05) as compared with controls. These levels were ameliorated significantly after vitamin E supplementation (p < 0.05) in group II. However, elevated levels of serum CRP and synovial fluid IL-6 (r = 0.034; p < 0.05) were decreased insignificantly (p < 0.1) after vitamin E supplementation in knee OA patients. Conclusions: These findings confirm the protective role of vitamin E supplementation against oxidative stress mediated biomolecular deterioration in OA. However, the anti-inflammatory role of vitamin E remains to be explored.

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Section: Discussionmentioning

confidence: 99%

Efficacy of vitamin E in knee osteoarthritis management of North Indian geriatric population

Bhattacharya¹,

Saxena²,

Gupta³

2011

Therapeutic Advances in Musculoskeletal

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“…Previous studies [20] have shown that lipid peroxidation was increased in osteoporosis due to oxidative stress. We were interested in measuring the status of antioxidant vitamin i.e.…”

Section: Resultsmentioning

confidence: 85%

Effect of Antiresorptive Therapy on Urinary Hydroxyproline in Postmenopausal Osteoporosis

Jagtap

Ganu

2011

Ind J Clin Biochem

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Osteoporosis becomes a serious health threat for older postmenopausal women by predisposing them to an increased risk of fracture. Osteoporosis and associated fractures are an important cause of morbidity and mortality. Special attention is being paid to early detection, management, and treatment of postmenopausal osteoporosis in women. Biochemical markers can enable dynamic and rapid measurement of total body skeletal metabolism and will be clinically useful in the management of postmenopausal osteoporosis women (PMO) and also for assessing the effects of antiresorptive therapy. With this view, we planned to assess osteoclastic activity by determining urinary hydroxyproline in osteoporotic women. The aim of this study is to measure urinary hydroxyproline (expressed as mg of hydroxyproline/g of creatinine) and serum ascorbic acid in postmenopausal women with osteoporosis and without osteoporosis. These biochemical parameters were determined 3 months post antiresorptive therapy (alendronate ? calcium ? vitamin D) in postmenopausal osteoporosis patients. 60 postmenopausal women with osteoporosis in the age group 45-60 years and 60 healthy postmenopausal women (normal bone mineral density) in the same age group were included in the study. Urinary hydroxyproline levels were significantly increased (P \ 0.001) in PMO at baseline level as compared to control group. These levels were decreased significantly (P \ 0.001) post therapy in PMO patients. Serum vitamin C levels were significantly decreased (P \ 0.001) in PMO patients at baseline level as compared to controls. No significant change occurred of serum vitamin C level post therapy. Raised excretion of hydroxyproline at the baseline level might be due to increased degradation of collagen type I from the bone matrix in osteoporosis. Breakdown of collagen seems to be lowered as reflected by lowering of hydroxyproline excretion post antiresorptive therapy. Alteration in the concentration of this marker can be very well utilized to monitor the effectiveness of therapy. Thus simple, direct urinary assay to measure bone resorption is very useful in monitoring the therapy in PMO and may become an integral part of the management of osteoporosis.

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“…Intervention studies show mixed results, which may be due to trial length. postmenopausal women receiving 10g/d oral vitamin C showed no effect on markers of bone turnover in a four week study 73 , although 1000mg/d given with 600mg/d vitamin e for six months showed a significant improvement in spine BMD 74 and 500mg/d vitamin C in combination with 400mg/d vitamin e for 90 days increased sod, gsh and osteoblastic markers in osteoporosis patients 10 . although humans have lost the ability to synthesis vitamin C, knock-out studies in animals show that vitamin C deficiency correlated with increased fracture risk, decreased expression of bone formation markers 75 and increased osteoclastogenesis by increasing expression of raNK 76 , while treatment generally reduced bone fragility and improved healing, BMd and osteoblastic survival 28,77 , while reducing lipid peroxidation and osteoclast differentiation, with decreasing NF-kappaB and raNKl expression 78 .…”

Section: Calcificationmentioning

confidence: 91%

“…Valabhji et al found that the inverse association between total antioxidant status and CaC became non-significant after adjustment for age and/or diabetes duration 22 , while a sod mimetic could reduce induced medial calcification in rats 23 but worsened aortic valve calcification 13 . Nevertheless, antioxidants can generally inhibit raNKl expression 8,9 , while vitamins C and e also act by increasing serum sod and gsh 10 and selenium by increasing glutathione peroxidase levels 25 . Zinc can also raise insulin-like growth factor (IgF) 1, known to be involved in bone formation 26 , although in VSMC the driver for calcification may be IGF-2 27 .…”

Section: Oxidative Stress CV Calcificationmentioning

confidence: 99%

“…While a certain level of ROS production is necessary for an effective immune response, overproduction induces an imbalance between cellular and tissue pro-oxidants and endogenous antioxidant enzymes, such as superoxide dismutase (sod), catalase (Cat) and glutathione peroxidase (gpx), which may decline with age and lack of appropriate dietary nutrients. 5,7 antioxidants generally can inhibit expression of receptor activator of NF-kB ligand (raNKl) 8,9 , while vitamins C and e also act by increasing serum sod and gsh 10 .…”

Section: Introductionmentioning

confidence: 99%

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Cardiovascular calcification and bone: a comparison of the effects of dietary and serum antioxidants

Nicoll¹,

Howard²,

Henein³

2015

ICFJ

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<p>Severe cardiovascular (CV) calcification can manifest as fully formed bone and is regularly found with osteoporosis; both have been shown to be associated with oxidative stress. Studies of the effect of antioxidants on CV calcification are few, but show that deficiency can induce both CV calcification and bone loss, while in conditions of oxidative stress such as renal failure, diabetes and smoking or in osteoporosis and fracture, antioxidants can reduce CV calcification and improve bone. The benefit of antioxidants in healthy adults is less clear and some may be detrimental. Higher intake of <em>α</em>-tocopherol (105.5mg/d vs 76.4mg/d) and β-cryptoxanthin may increase risk of CV calcification while high intake of retinol (≥3000mcg/d) may increase hip fracture risk, although possibly only with vitamin D intake ≤440IU/d; the carotenoids lycopene and β-carotene, however, appear beneficial in bone. Vitamin C shows little effect on CV calcification, although longer term supplementation may improve bone mineral density where calcium intake is >500mg/d. Potential reasons for this include a U-shaped dose/response curve for the fat-soluble antioxidants vitamins A and E (with peak bone mass achieved with retinol intake of 600–840 mcg/d), a failure to measure baseline concentrations so that the response cannot be stratified by requirement, the need to be replete in calcium and vitamin D and supplementation of the wrong isomer of vitamin E. Finally, although little studied, tocotrienols, tocopherols (with the exception of α-tocopherol), resveratrol, epigallocatechin gallate, quercetin, α-lipoic acid and N-acetylcysteine may be effective in both the CV system and bone. </p>

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Effect of supplementation of vitamin C and E on oxidative stress in osteoporosis

Cited by 39 publications

References 8 publications

Efficacy of vitamin E in knee osteoarthritis management of North Indian geriatric population

Efficacy of vitamin E in knee osteoarthritis management of North Indian geriatric population

Effect of Antiresorptive Therapy on Urinary Hydroxyproline in Postmenopausal Osteoporosis

Cardiovascular calcification and bone: a comparison of the effects of dietary and serum antioxidants

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