Effect of supplemental phytonutrients on impairment of the flow-mediated brachialartery vasoactivity after a single high-fat meal

Plotnick, Gary D.; Corretti, Mary C.; Vogel, Robert A.; Hesslink, R. L.; Wise, John A.

doi:10.1016/s0735-1097(03)00302-4

Cited by 81 publications

(67 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Earlier studies have demonstrated that elevations in lipid availability through either acute lipid/heparin infusions or short-term high-fat diets can induce impairments in insulin-mediated glucose uptake in lean insulin-sensitive individuals. Such impairments in insulin-mediated glucose disposal in response to lipid and heparin infusions or high-fat diets are commonly attributed to impaired insulin signalling events within skeletal muscle fibres (Ellis et al 2000;Itani et al 2002;Shulman 2000;Yu et al 2002) and/or to lipid-mediated endothelial dysfunction (Bae et al 2003;Clerk et al 2002;de Jongh et al 2004;Fard et al 2000;Gosmanov et al 2010;Plotnick et al 2003;Vogel et al 1997). The magnitude and time course of the lipemic response to the test meals was not measured in the present study; however, earlier studies have demonstrated that similar highfat meals induce elevations in plasma TAG and a delayed rise in plasma FFA 3-6 h after feeding (Giacco et al 2004;Gosmanov et al 2010).…”

Section: Discussionmentioning

confidence: 99%

Acute high-fat feeding does not prevent the improvement in glucose tolerance after resistance exercise in lean individuals

et al. 2011

View full text Add to dashboard Cite

Our first aim was to investigate whether the ingestion of a single high-fat meal impairs glucose tolerance. Our second aim was to investigate whether improvements in glucose tolerance that are seen after resistance exercise remain when exercise is performed after ingestion of a high-fat meal. Eight young males consumed either a high fat (HF) or an isocaloric control (CON) meal in the morning and underwent an oral glucose tolerance test (OGTT) 6 h later. On two other occasions, a single 1 h bout of resistance exercise was completed 2 h after consumption of each meal (HFE and CONE). There were no significant differences in plasma glucose and plasma insulin areas under the curve (AUC) or estimates of insulin sensitivity between the HF and CON trials (P > 0.05). The HFE and CONE trials elicited a ~20% lower plasma glucose AUC (P < 0.05) compared to their respective control trials. The HFE also elicited a ~25% lower plasma insulin AUC (P < 0.05) in comparison to the HF trial. The HFE trial also significantly improved estimates of insulin sensitivity in comparison to the HF condition (P < 0.05). In conclusion, this study demonstrates that consumption of a single HF meal does not impair glucose tolerance in the resting state in lean individuals and that an acute bout of resistance exercise remains effective in enhancing glucose tolerance following the ingestion of a single high-fat meal.

show abstract

Section: Discussionmentioning

confidence: 99%

Acute high-fat feeding does not prevent the improvement in glucose tolerance after resistance exercise in lean individuals

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Many previous studies have shown that a single meal containing high levels of saturated fat impairs endothelial function for 2 to 6 h (for review, see [10,11]), and there is evidence that other nutrients contained in a meal can modify this response [12,13]. Few studies have examined acute vascular effects of polyunsaturated and monounsaturated fatty acids (MUFA) [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Acute effects of monounsaturated fatty acids with and without omega-3 fatty acids on vascular reactivity in individuals with type 2 diabetes

et al. 2004

View full text Add to dashboard Cite

Aims/hypothesis: We examined the acute postprandial effects of meals containing unsaturated fatty acids on flow-mediated dilation (FMD) of the brachial artery and triacylglycerols in individuals with type 2 diabetes. We hypothesised that consumption of omega-3 fatty acids would enhance vascular function. Saturated fat reduces FMD for several hours, but there is inconsistent evidence about whether foods containing unsaturated fats impair FMD acutely. Little is known about the acute effects of omega-3 fatty acids on vascular reactivity. Methods: We measured FMD before and 4 h after 3 test meals (50 g fat, 2,615 kJ) in 18 healthy adults with type 2 diabetes. The monounsaturated fatty acids (MUFA) meal contained 50 g fat from high oleic safflower and canola oils. Two additional meals were prepared by replacing 7% to 8% of MUFA with docosahexaenoic acid and eicosapentaenoic acid from sardine oil or α-linolenic acid from canola oil. Results: In the sample as a whole, FMD was increased 17% at 4 h vs. the fasting baseline. After the MUFA meal, subjects with the largest increases in triacylglycerols had the largest FMD decreases. The opposite pattern was observed after meals containing docosahexaenoic acid and eicosapentaenoic acid or α-linolenic acid. In subjects with high fasting triacylglycerols, meals containing 3 to 5 g of omega-3 fatty acids increased FMD by 50% to 80% and MUFA alone had no significant effects on FMD. Conclusions/ interpretation: Endothelium-dependent vasodilation was not impaired 4 h after meals containing predominantly unsaturated fatty acids. The fatty acid composition of the meal and the metabolic status of the individual determine the vascular effects of a high-fat meal.

show abstract

“…A high-fat meal is usually followed by transient endothelial dysfunction in association with raised triglyceride-rich lipoproteins (6). Abnormal vasoactivity after a fatty meal is attenuated by pretreatment with antioxidant phytochemicals (7) or addition of antioxidants to the meal (8,9), suggesting that postprandial oxidative stress plays an important role. Elevated concentrations of the endogenous NO inhibitor ADMA may also contribute to fatty meal-induced endothelial dysfunction (3).…”

mentioning

confidence: 99%

Acute Effects of High-Fat Meals Enriched With Walnuts or Olive Oil on Postprandial Endothelial Function

Cortés

Núñez²,

Cofán³

et al. 2006

Journal of the American College of Cardiology

200

166

View full text Add to dashboard Cite

show abstract

Effect of supplemental phytonutrients on impairment of the flow-mediated brachialartery vasoactivity after a single high-fat meal

Abstract: Daily ingestion of modest amounts of a fruit/vegetable juice concentrate with or without adjunctive phytonutrient supplementation can reduce the immediate adverse impact of high-fat meals on flow-mediated vasoactivity and increase nitrate/nitrite blood concentration.

Cited by 81 publications

References 51 publications

Acute high-fat feeding does not prevent the improvement in glucose tolerance after resistance exercise in lean individuals

Acute high-fat feeding does not prevent the improvement in glucose tolerance after resistance exercise in lean individuals

Acute effects of monounsaturated fatty acids with and without omega-3 fatty acids on vascular reactivity in individuals with type 2 diabetes

Acute Effects of High-Fat Meals Enriched With Walnuts or Olive Oil on Postprandial Endothelial Function

Contact Info

Product

Resources

About