Effect of sugars in solutions on subjective appetite and short-term food intake in 9- to 14-year-old normal weight boys

Engelen, Marissa Van; Khodabandeh, S; Akhavan, Tina; Agarwal, Jolly; Gladanac, Branka; Bellissimo, Nick

doi:10.1038/ejcn.2014.33

Cited by 19 publications

(25 citation statements)

References 41 publications

(70 reference statements)

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“…Total dietary fructose has been shown to be positively related to increased visceral adiposity, increased blood pressure, and HOMA-IR in a large sample of adolescents (Pollock et al, 2012). An experiment comparing glucose, HFCS, sucrose, and sucralose found that food intake after a HFCS or sucrose drink led to higher energy intake at a subsequent ad libitum meal (Van Engelen et al, 2014). …”

Section: Introductionmentioning

confidence: 99%

“…Previous research has focused on the satiating action of acute intake of either fiber or SSB (Chang et al, 2012; Soenen & Westerterp-Plantenga, 2007; Van Engelen et al, 2014b; A J Wanders et al, 2011; Anne J Wanders et al, 2013). Research has shown acute satiety after a sugar pre-load (Anderson & Woodend, 2003), however the effect of prolonged sugar consumption is, to date, understudied.…”

Section: Introductionmentioning

confidence: 99%

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The impact of sugar sweetened beverage intake on hunger and satiety in minority adolescents

et al. 2016

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This study hypothesized that high versus low habitual intake of SSBs would result in greater hunger, decreased fullness, and a blunted gut hormone response after a high sugar low fiber (HSLF) and a low sugar high fiber meal (LSHF). This was a randomized crossover feeding trial with 47 overweight/obese African American and Hispanic adolescents (mean age=15.6 y, 48% female, 35% African American). Participants were randomly fed a HSLF or LSHF breakfast and lunch followed by an ad libitum meal. During the breakfast and lunch, blood was drawn every 30 minutes on a subset of 18 subjects. During the entire visit, hunger and fullness visual analogue scales were completed every 30 minutes for 5 hours. Subjects were grouped into the following habitual SSB categories: low (蠄1 SSB serv/day), medium (>1 ‐ <2 serv/day), and high (蠅2 serv/day). Mixed modeling was used to explore how SSB categories predicted ghrelin/PYY values and hunger/fullness ratings. The low group had lower hunger ratings compared to the high group (p<0.01) and higher ghrelin concentrations compared to the medium and high group (p=0.02). The LSHF meal was rated less filling than the HSLF (p=0.05). The medium group showed the highest PYY concentrations (p=0.03). Habitual SSB intake appears to impact hunger/fullness. Support: NCHMD P60 MD002254

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The impact of sugar sweetened beverage intake on hunger and satiety in minority adolescents

et al. 2016

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“…Those dieting, taking medications affecting brain physiology, breakfast skippers, or with learning, behavioral, or emotional difficulties were excluded from the study. Participant characteristics are described in greater detail in our previous publication (11). The study was approved by the Research Ethics Board, Mount Saint Vincent University.…”

Section: Participantsmentioning

confidence: 99%

“…The subjective appetite and food intake data were previously reported (11). Following a telephone screening interview with the parent, an in-person interview was scheduled where informed written consent and assent were obtained from the parent and child, respectively.…”

Section: Protocolmentioning

confidence: 99%

“…Following a telephone screening interview with the parent, an in-person interview was scheduled where informed written consent and assent were obtained from the parent and child, respectively. Anthropometric measurements including height (m), weight (kg) and skinfold measurements (mm) at four points (triceps, biceps, supra-ilial, and subscapular) were taken as previously reported (11).…”

Section: Protocolmentioning

confidence: 99%

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Effect of Sugars in Solutions on Immediate and Delayed Word List Recall in Normal Weight Boys

Akhavan¹,

Eskritt²,

Engelen³

et al. 2014

Int J School Health

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Background: Dietary glucose improves memory performance in several adult populations; however, there are no comparative studies of commonly consumed sugars on memory performance in children. Objectives:The objective was to compare the effect of glucose, sucrose and high-fructose corn syrup-55 (HFCS) solutions on immediate and delayed word list recall in 9 to 14 year-old normal weight boys. Patients and Methods:In a repeated measures design, 15 normal weight boys received, in random order, preloads (200 kcal/250 mL) of glucose, sucrose, HFCS, or non-caloric sucralose control. The boys were presented with a 15 item word list to memorize 15 minutes after ingestion of the preloads and asked to recall the words immediately after, and at 30, 45, 60 and 90 minutes. Results: There were no significant differences among the glucose, sucrose and HFCS preloads on word list recall compared with the noncaloric sucralose control at any of the time points. However, word list recall was highest at 15 minutes, and decreased over time to 90 minutes after all preloads (P < 0.0001). Conclusions: Sugars in solutions do not differ in their effects on word list memory recall compared with a non-caloric sucralose control in 9 to 14 year-old normal weight boys.

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Glucose Can Epigenetically Alter the Gene Expression of Neurotrophic Factors in the Murine Brain Cells

2017

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Glucose is believed to improve the memory in both human and mice, but the detailed insights were mostly elusive. In this study, we focused on two major neurotrophic factors, brain-derived neurotrophic factor (BDNF) and fibroblast growth factor 1 (FGF1), which are believed to be associated with the memory enhancement and assessed their expressional regulation among the murine neuronal and glial cells. Our findings showed that the glucose administration increased phosphorylated Akt, phosphorylated CREB, exon 1- and exon 4-specific BDNF transcripts, and FGF1 transcripts that are associated with the epigenetic changes expected to open the chromatin and a reduction in histone deacetylase 2 (HDAC2) in neurons and astrocytes of the murine hippocampus. The glucose administration enhanced the long-term potentiation and the number of dendritic spines in the CA1 and CA3 subfields of hippocampus. The intrahippocampal injection of short hairpin RNA against TrkB canceled the glucose-mediated memory enhancement. Like the glucose, we also report that the HDAC inhibitor can enhance the memory through the BDNF-TrkB pathway but it targeted different brain cell populations to enhance the BDNF and FGF1 transcripts. In addition, the soluble FGF1 treatments significantly increased the BDNF expression in astrocytes and neurons, suggesting that the glucose-mediated induction of the neurotrophic factors could contribute to the memory. Our study provides the valuable insights, explaining the distinctive neuronal and glial cell regulation of the neurotrophic factors by glucose and HDAC inhibitor, which could likely explain how our brain cells can control the release of neurotrophic factors.

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Effect of sugars in solutions on subjective appetite and short-term food intake in 9- to 14-year-old normal weight boys

Abstract: Change from baseline subjective average appetite was the highest after sucrose, but only the glucose solution suppressed FI at the test meal 60 min later in NW boys.

Cited by 19 publications

References 41 publications

The impact of sugar sweetened beverage intake on hunger and satiety in minority adolescents

The impact of sugar sweetened beverage intake on hunger and satiety in minority adolescents

Effect of Sugars in Solutions on Immediate and Delayed Word List Recall in Normal Weight Boys

Glucose Can Epigenetically Alter the Gene Expression of Neurotrophic Factors in the Murine Brain Cells

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