Effect of successful weight loss program on biomarkers for breast cancer in postmenopausal high-risk women.

Fabian, CJ; Klemp, Jennifer R.; Kimler, BF; Aversman, Sonya; Phillips, Teresa A.; Zalles, CM; Sullivan, Debra K.; Smith, B. L.; Donnelly, J.

doi:10.1200/jco.2010.28.15_suppl.1522

Cited by 3 publications

(4 citation statements)

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“…The weight management clinics [Weight Control Research Project (WCRP)] were based on Social Cognitive Theory (SCT) and have been directed by the PI (JED) of the current trial for over 25 years . Behavioral clinic meetings for both groups were conducted weekly during the weight loss phase (month 0‐6), and then gradually reduced during weight maintenance (months 7‐18).…”

Section: Methods and Proceduresmentioning

confidence: 99%

Equivalent weight loss for weight management programs delivered by phone and clinic

Donnelly

Goetz

Gibson

et al. 2013

Obesity

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Objective Face-to-face weight management is costly and presents barriers for individuals seeking treatment; thus, alternate delivery systems are needed. The objective of this study was to compare weight management delivered by face-to-face (FTF) clinic or group conference calls (phone). Design and Methods Randomized equivalency trial in 295 overweight/obese men/women (BMI = 35.1±4.9, Age = 43.8±10.2, Minority = 39.8%). Weight loss (0–6 months) was achieved by reducing energy intake between 1,200– 1,500 kcal/day and progressing physical activity to 300 minutes/week. Weight maintenance (7–18 months) provided adequate energy to maintain weight and continued 300 minutes/week of physical activity. Behavioral weight management strategies were delivered weekly for 6 months and gradually reduced during months 7–18. A cost analysis provided a comparison of expenses between groups. Results Weight change from baseline to 6 months was −13.4 ± 6.7% and −12.3 ± 7.0% for FTF clinic and phone, respectively. Weight change from 6 months to 18 months was 6.4 ± 7.0% and 6.4 ± 5.2%, for FTF clinic and phone, respectively. The cost to FTF participants was $789.58 more person. Conclusions Phone delivery provided equivalent weight loss and maintenance and reduced program cost. Ubiquitous access to phones provides a vast reach for this approach.

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Section: Methods and Proceduresmentioning

confidence: 99%

Equivalent weight loss for weight management programs delivered by phone and clinic

Donnelly

Goetz

Gibson

et al. 2013

Obesity

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“…In previous investigations by our group using a similar diet, weight loss at 3 months averaged 12.5% (range (11.1-13.7%) [41, 43, 47]. Participants reaching a BMI of 22 kg/m 2 during weight loss will be transitioned to the prevention of weight regain diet described below; however, in our experience, this is an infrequent occurrence.…”

Section: Methodsmentioning

confidence: 64%

“…The weight loss and weight regain prevention diets for this study will be based on 25 + years of experience with weight management [41-43, 46, 47]. EI will be reduced to ~1,200 to 1,500 kcal/day using a combination of commercially available prepackaged meals (PM’s), fruits and vegetables, low calorie shakes, and non-caloric beverages.…”

Section: Methodsmentioning

confidence: 99%

The Midwest Exercise Trial for the Prevention of Weight Regain: MET POWeR

Szabo

Washburn

Sullivan

et al. 2013

Contemporary Clinical Trials

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Weight reduction in overweight and obese individual’s results in physiological and behavioral changes that make the prevention of weight regain more difficult than either initial weight loss or the prevention of weight gain. Exercise is recommended for the prevention of weight regain by both governmental agencies and professional organizations. To date, the effectiveness of exercise recommendations for the prevention of weight regain has not been evaluated in a properly designed, adequately powered trial. Therefore, we will conduct a randomized trial to evaluate the effectiveness of 3 levels of exercise on the prevention of weight regain, in initially overweight and obese sedentary men and women. Participants will complete a 3 month weight loss intervention of decreased energy intake (EI) and increased exercise (100 minutes/week). Participants achieving clinically significant weight loss (≥ 5% of initial weight), will then be randomly assigned to 12 months of verified exercise at 3 levels (150, 225 or 300 minutes/week). This study will evaluate: 1) the effectiveness of 3 levels of exercise on the prevention of weight regain over 12 months subsequent to clinically significant weight loss (≥ 5%); 2) gender differences in weight regain in response to 3 levels of exercise; and 3) potential compensatory changes in daily physical activity (PA) and EI on weight regain in response to 3 levels of exercise. Results of this investigation will provide information to develop evidenced based recommendations for the level of exercise associated with the prevention of weight regain.

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“…When combined with a variety of fruits and vegetables, PCM's (entrees + shakes) provide a diet with all necessary nutrients specified by the Dietary Reference Intakes [53]. The weight loss and weight regain prevention diets for this study will be based on 25+ years of investigator experience with weight management [54-58]. Participants reaching a BMI of 22 kg/m 2 during weight loss will be transitioned to the prevention of weight regain diet described below; however, in our experience, this is an infrequent occurrence…”

Section: Methodsmentioning

confidence: 99%

Brain function predictors and outcome of weight loss and weight loss maintenance

Szabo-Reed

Breslin

Lynch

et al. 2015

Contemporary Clinical Trials

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Obesity rates are associated with public health consequences and rising health care costs. Weight loss interventions, while effective, do not work for everyone, and weight regain is a significant problem. Eating behavior is influenced by a convergence of processes in the brain, including homeostatic factors and motivational processing that are important contributors to overeating. Initial neuroimaging studies have identified brain regions that respond differently to visual food cues in obese and healthy weight individuals that are positively correlated with reports of hunger in obese participants. While these findings provide mechanisms of overeating, many important questions remain. It is not known whether brain activation patterns change after weight loss, or if they change differentially based on amount of weight lost. Also, little is understood regarding biological processes that contribute to long-term weight maintenance. This study will use neuroimaging in participants while viewing food and non-food images. Functional Magnetic Resonance Imaging will take place before and after completion of a twelve-week weight loss intervention. Obese participants will be followed though a 6-month maintenance period. The study will address three aims: 1. Characterize brain activation underlying food motivation and impulsive behaviors in obese individuals. 2. Identify brain activation changes and predictors of weight loss. 3. Identify brain activation predictors of weight loss maintenance. Findings from this study will have implications for understanding mechanisms of obesity, weight loss, and weight maintenance. Results will be significant to public health and could lead to a better understanding of how differences in brain activation relate to obesity.

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Effect of successful weight loss program on biomarkers for breast cancer in postmenopausal high-risk women.

Cited by 3 publications

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Equivalent weight loss for weight management programs delivered by phone and clinic

Equivalent weight loss for weight management programs delivered by phone and clinic

The Midwest Exercise Trial for the Prevention of Weight Regain: MET POWeR

Brain function predictors and outcome of weight loss and weight loss maintenance

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