Effect of Subthalamic Nucleus or Globus Pallidus Interna Stimulation on Oculomotor Function in Patients with Parkinson’s Disease

Fridley, Jared; Adams, Gerald J.; Sun, Peng; York, Michelle M.; Atassi, Farah; Lai, Eugene C.; Simpson, Richard K.; Viswanathan, Ashwin; Yoshor, Daniel

doi:10.1159/000343200

Cited by 8 publications

(7 citation statements)

References 60 publications

(44 reference statements)

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“…The pathophysiology of SWJs is unknown, but they have been related to disruption of cerebral, cerebellar, basal ganglia function [33], [34] and specifically in lesions of the GP [16], [33], [35]. High number of SWJ has been previously reported in PD [36], after unilateral pallidotomy [16], [37], or stimulation of the nucleus subthalamicus [38], and they have also been found in progressive supranuclear palsy (PSP) [39]. Similar to PSP, EP patients show gait and speech disturbances, and a non levodopa responsive parkinsonian syndrome.…”

Section: Discussionmentioning

confidence: 99%

Eye Movements in Ephedrone-Induced Parkinsonism

et al. 2014

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Patients with ephedrone parkinsonism (EP) show a complex, rapidly progressive, irreversible, and levodopa non-responsive parkinsonian and dystonic syndrome due to manganese intoxication. Eye movements may help to differentiate parkinsonian syndromes providing insights into which brain networks are affected in the underlying disease, but they have never been systematically studied in EP. Horizontal and vertical eye movements were recorded in 28 EP and compared to 21 Parkinson's disease (PD) patients, and 27 age- and gender-matched healthy subjects using standardized oculomotor tasks with infrared videooculography. EP patients showed slow and hypometric horizontal saccades, an increased occurrence of square wave jerks, long latencies of vertical antisaccades, a high error rate in the horizontal antisaccade task, and made more errors than controls when pro- and antisaccades were mixed. Based on oculomotor performance, a direct differentiation between EP and PD was possible only by the velocity of horizontal saccades. All remaining metrics were similar between both patient groups. EP patients present extensive oculomotor disturbances probably due to manganese-induced damage to the basal ganglia, reflecting their role in oculomotor system.

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Section: Discussionmentioning

confidence: 99%

Eye Movements in Ephedrone-Induced Parkinsonism

et al. 2014

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“…There is evidence that patients with Parkinson disease (PD) who receive deep brain stimulation (DBS) of the STN experience a significant improvement in both saccadic performance [ 92 , 93 ] and locomotion [ 93 - 95 ] compared to patients that receive other DBS targets, such as the globus pallidus interna (GPi). GPi DBS has been shown to improve locomotion [ 96 ], but there is less evidence supporting an improvement in saccadic performance [ 97 ], though one study found improvement in antisaccades [ 98 ].…”

Section: Neural Components Of Saccades Fixations and Locomotionmentioning

confidence: 99%

The Relationship between Saccades and Locomotion

Srivastava

Ahmad

Pacia

et al. 2018

JMD

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Human locomotion involves a complex interplay among multiple brain regions and depends on constant feedback from the visual system. We summarize here the current understanding of the relationship among fixations, saccades, and gait as observed in studies sampling eye movements during locomotion, through a review of the literature and a synthesis of the relevant knowledge on the topic. A significant overlap in locomotor and saccadic neural circuitry exists that may support this relationship. Several animal studies have identified potential integration nodes between these overlapping circuitries. Behavioral studies that explored the relationship of saccadic and gait-related impairments in normal conditions and in various disease states are also discussed. Eye movements and locomotion share many underlying neural circuits, and further studies can leverage this interplay for diagnostic and therapeutic purposes.

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“…Although all saccades share this final common pathway, differing task demands can result in differential recruitment of higher-level control areas. As with voluntary body movements, voluntary saccades seem to be Fischer et al, 2016;Goelz et al, 2017;Lohnes & Earhart, 2012;Nilsson et al, 2013;Sauleau et al, 2008;Temel et al, 2008;Yugeta et al, 2010Yugeta et al, , 2013 ↑ A ↓ L Gpi DBS (Antoniades et al, 2015;Fridley et al, 2013) No eff VIM DBS (Kronenbuerger et al, 2010) ↓ L STN DBS Sauleau et al, 2008, Temel et al, 2008, Yugeta et al, 2010, Lohnes & Earhart, 2012, Nilsson et al, 2013, Yugeta et al, 2013, Fischer et al, 2016, Dec-Cwiek et al, 2017, Goelz et al, 2017 (Fujiwara et al, 2017) No eff R STN DBS…”

Section: Saccadesmentioning

confidence: 99%