Effect of Subanesthetic Concentrations of Halothane and Methoxyflurane on Pain Threshold in Conscious Volunteers

Siker, Ephraim S.; Wolfson, Bernard; Ciccarelli, Harold E.; Telan, Ruben A.

doi:10.1097/00000542-196703000-00011

Cited by 19 publications

(18 citation statements)

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“…In anesthetized animals, it is possible that a specific nociceptive threshold involves both peripheral and central anesthetic effects (Cornett et al, 2008;Devor and Zalkind, 2001). A previous human study reported that the pain threshold was increased by anesthesia (Siker et al, 1967). Thus, there are significant advantages to observing mechanical nociception in the oral cavity of conscious animals.…”

Section: Discussionmentioning

confidence: 99%

Novel methods of applying direct chemical and mechanical stimulation to the oral mucosa for traditional behavioral pain assays in conscious rats

Hitomi

Ono

Miyano³

et al. 2015

Journal of Neuroscience Methods

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Section: Discussionmentioning

confidence: 99%

Novel methods of applying direct chemical and mechanical stimulation to the oral mucosa for traditional behavioral pain assays in conscious rats

Hitomi

Ono

Miyano³

et al. 2015

Journal of Neuroscience Methods

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“…Using the same analgesimetry method, Dundee and Love [14] found no increase in pain thresholds when subanaesthetic concentrations of methoxyflurane were inhaled. Later studies found that halothane increased pain thresholds to heat [15] and pressure [5,15], and that methoxyflurane increased pain thresholds to pressure [4,5]. In these older studies, simple pain models were used, and most measurements were performed under nonsteady state conditions.…”

Section: Discussionmentioning

confidence: 99%

“…The analgesic effect at subanaesthetic concentrations of the "older" inhalation anaesthetics (ether, trichloroethylene, methoxyflurane and halothane) has been investigated using either clinical assessment or pain threshold measurements [2][3][4][5], but with conflicting results. The purpose of the present study was to evaluate the analgesic effects of isoflurane on different pain modalities, using experimental models.…”

Section: Introductionmentioning

confidence: 99%

The analgesic effect in humans of subanaesthetic isoflurane concentrations evaluated by experimentally induced pain

Petersen-Felix

Arendt‐Nielsen

Bak

et al. 1996

European Journal of Anaesthesiology

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SummaryThe analgesic effect of subanaesthetic concentrations of ether, trichloroethylene, methoxyflurane and halothane has been investigated previously using either clinical assessment or pain threshold measurements, but with conflicting results. The purpose of the present study was to evaluate the analgesic effect of isoflurane using experimental pain models. We studied 12 healthy volunteers at three randomly chosen subanaesthetic isoflurane concentrations: low (0.10-0.14 vol %), middle (0.16-0.20 vol %) and high (0.22-0.26 vol %). We used thermal pain detection and pain tolerance thresholds to argon laser stimulation, pressure pain detection and pain tolerance thresholds, immersion of the hand in ice water, and the nociceptive reflex to single and repeated (temporal summation) electrical stimulations, as experimental models to assess analgesia. There were no significant changes in the response to heat, cold or mechanical pressure at any of the subanaesthetic concentrations of isoflurane used. The nociceptive reflex thresholds to single stimulations, but not the thresholds for repeated stimulations, were significantly increased in all three isoflurane groups compared with baseline values. The difference between the different isoflurane concentrations was not statistically significant. In experimental pain models, subanaesthetic isoflurane concentrations have little or no analgesic potency. (Br. J. Anaesth. 1995; 75: 55-60)

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“…7 An assessment of six inhalation anaesthetic agents used at sub-anaesthetic concentrations found that methoxyflurane and nitrous oxide possessed both analgesic and hypnotic actions, which halothane, enflurane, isoflurane and sevoflurane did not. 8 A role for methoxyflurane was suggested in situations where general anaesthesia was a significant hazard or regional anaesthesia was deemed impractical or contraindicated.…”

Section: Accepted Articlementioning

confidence: 99%

Methoxyflurane: a review with emphasis on its role in dental practice

Kingon¹,

Yap

Bonanno

et al. 2016

Australian Dental Journal

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Publishing in a subscription based journal Accepted (peer-reviewed) VersionThe accepted version of an article is the version that incorporates all amendments made during the peer review process, but prior to the final published version (the Version of Record, which includes; copy and stylistic edits, online and print formatting, citation and other linking, deposit in abstracting and indexing services, and the addition of bibliographic and other material.

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Effect of Subanesthetic Concentrations of Halothane and Methoxyflurane on Pain Threshold in Conscious Volunteers

Cited by 19 publications

References 0 publications

Novel methods of applying direct chemical and mechanical stimulation to the oral mucosa for traditional behavioral pain assays in conscious rats

Novel methods of applying direct chemical and mechanical stimulation to the oral mucosa for traditional behavioral pain assays in conscious rats

The analgesic effect in humans of subanaesthetic isoflurane concentrations evaluated by experimentally induced pain

Methoxyflurane: a review with emphasis on its role in dental practice

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