Effect of subacute administration of three organophosphorus pesticides on the hepatic phosphatases under various nutritional conditions

Malathion-induced hepatotoxicity in male Wistar rats: biochemical and histopathological studies

“…According to the literature, malathion may cause hepatocyte necrosis (Deckers-Passau et al 1957;Bulsu and Chakravarty 1987). In the same context, the administration, by gavage, of dichlorvos (1.6 mg/kg for 7 weeks), an OP insecticide, to adult male rats caused hepatocellular necrosis in addition to other liver damages (Ogutcu et al 2008).…”

“…The membrane of these organelles may also undergo LPO by ROS, and there is a spill of liposomal enzyme content in the hepatocyte cytoplasm which wills necrotic hepatocytes (Deckers-Passau et al 1957;Bulsu and Chakravarty 1987) which can be another cause of the necrosis observed.…”