Effect of Sub-Lethal Concentrations of Endosulfan on Hematological and Serum Biochemical Parameters in the Carp Cyprinus carpio

Jenkins, Fameeka S.; Smith, Judy V.; Rajanna, B.; Shameem, U.; Umadevi, K.; Sandhya, V.; Madhavi, R.

doi:10.1007/s00128-003-0080-7

Cited by 77 publications

(45 citation statements)

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“…Also, Svobodova et al (2003) reported significantly lower values of red blood cells and Hb in Cyprinus carpio after acute exposure to deltamethrin. The reduction in hemoglobin might be due to the inhibition of erythropoiesis, hemosynthesis, osmoregulatory dysfunction or due to increased rate of erythrocyte destruction in the hematopoietic organ, as reported in Cyprinus carpio exposed to endosulfan (Jenkins et al 2003). Whereas fish exposed to 0.50 and fed diet supplemented with 1 or 2 g vit.E/kg diet showed slightly increased Ht and Hb compared to the fish not exposed to fungicide and fed diet with normal level of vit.E, this indicates that supplemented diet with 1 or 2 g vit.E decreased the toxic effect of copperoxychloride and stimulated immune response to cope up the copperoxychloride stress.…”

Section: Discussionmentioning

confidence: 90%

Protective effect of dietary vitamin E against fungicide copperoxychloride stress on Nile tilapia, Oreochromis niloticus (L.), fingerlings

et al. 2014

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A 2 9 3 factorial experiment was designed to study the effect of sublethal toxicity of technical grade copperoxychloride, dietary vitamin E and their interactions on growth performance, some blood parameters, DNA fragmentation and histopathological lesions of Nile tilapia (Oreochromis niloticus). The 96 h LC 50 of copperoxychloride was found to be 129.21 mg/l. Four hundred and fifty fingerlings with an average initial body weight ranged from 1.92 to 2.04 ± 0.11 g were randomly distributed equally in six treatments (T1-T6) with each of triplicates. T4, T5 and T6 were exposed to sublethal concentration 0.25 LC 50 of copperoxychloride. Fish of T1, T2 and T3 fed diet supplemented with different levels of vitamin E (0, 1 and 2 g/kg diet), respectively. While fish of T4, T5 and T6 fed diet supplemented with different levels of vitamin E (0, 1 and 2 g/kg diet), respectively. At the end of the experiment (90 days) the results indicated that fish exposed to 0.25 LC 50 of copperoxychloride and fed diet with normal level of vitamin E, showed significantly lower values (P \ 0.01) of all growth and feed utilization parameters, white blood cells and immunoglobulin M, but they showed significantly increased (P \ 0.05) values of alanine aminotransferase, aspartate aminotransferase, hematocrit, hemoglobin, uric acid and creatinine. Fish fed with varied concentrations of vitamin E neutralized the toxic effect of copperoxychloride as well as vitamin E, significantly lowered the hematological and biochemical response and enhanced the growth parameters and feed utilization. The toxic effect of copperoxychloride exposure and vitamin E feeding on histopathological alterations of liver and gill of the same studied fish will be taken in concern. The results showed improvement in samples treated with vitamin E. This study suggests that vitamin E can be effectively used to decrease the toxic effect of copperoxychloride on O. niloticus and its amelioration through dietary vitamin E supplementation.

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Section: Discussionmentioning

confidence: 90%

Protective effect of dietary vitamin E against fungicide copperoxychloride stress on Nile tilapia, Oreochromis niloticus (L.), fingerlings

et al. 2014

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“…46 Decreased protein level observed in this study may be attributed to stress mediated immobilization of these compounds to fulfill an increased element for energy by the organism to cope with environmental condition caused by the toxicant. 47 The depletion in total protein content may also be due to augmented proteolysis and possible utilization of their product for metabolic purposes as reported by Ravinder and Suryanarayana. 48 Neff 49 has opined that decline in protein content may be related to impaired food intake, increased energy cost of homeostasis, tissue repair and detoxification mechanism during stress.…”

Section: Articlementioning

confidence: 89%

Diazinon mediated biochemical changes in the African toad (Bufo regularis)

Tongo¹,

Ezemonye²,

Ochei

2012

J Xenobiotics

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The sublethal toxicity of diazinon to the adult African toad, Bufo regularis was assessed using an integration of biomarkers. Changes in acetylcholinesterase (AChE), corticosterone and total protein levels were assessed in the serum, brain, liver, lungs and gastrointestinal tract (GIT) and the results supported by bioaccumulation data. The biomarkers were chosen as indicators of key physiological functions: AChE for neurotoxicity, corticosterone and total protein levels as indicators of oxidative stress. Toads were exposed to 0.01, 0.02, 0.03 and 0.04 g/L for 28 days. Brain AChE activity reduced by 96% in the highest concentration (0.04 g/L) compared to the control brain. Similarly, AChE activities in serum, liver, lungs and GIT tissues (88%, 88%, 87, 87% umg -1 protein respectively) were also inhibited in the toads. Corticosterone and total protein levels in the tissues decreased compared to the control. The accumulation results obtained showed accumulation in the tissues (liver>serum>brain> lung>GIT), with a direct relationship between tissue concentration and changes in the biochemical indices. The alterations in all the indices were significantly concentration dependent. The biomarkers described in this study could be useful complementary indices in the risk assessment of diazinon pesticide.

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“…Holbrook (1980) stated that the toxicant can directly stop protein synthesis. Decrease in the liver and muscle protein level has been reported in Cyprinuscarpio exposed to endosulfan [Jenkins et al, 2003].…”

Section: Genomic Changesmentioning

confidence: 94%