Effect of stretch on the isolated cat sinoatrial node

Lange, Gertrude; Lu, HH; Chang, Audrey N.; Brooks, CM

doi:10.1152/ajplegacy.1966.211.5.1192

Cited by 71 publications

(43 citation statements)

References 2 publications

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“…As found in previous experiments performed on denervated atrium and isolated SA nodal tissue (LUDWIG and LUCHSINGER, 1881;BLINKS, 1956;DECK, 1963;BROOKS et al, 1966;LANGE et al, 1966), the increase in the pacemaker frequency was always observed by stretch or load application of isolated rabbit SA nodal tissue with normal discharge frequency of 200-250/min. The literature Japanese Journal of Physiology i imt Fig.…”

Section: Discussionsupporting

confidence: 83%

“…Concerning the link between the length changes and the pacemaker frequency changes in the pacemaker cells, LANGE et al (1966) suggest the stretch-induced reduction of membrane potential as a cause of the stretch-induced increase in discharge frequency. The stretch-induced reduction in membrane potential has also been reported on various excitable tissues such as vertebrate muscle spindle (KATZ, 1950), invertebrate stretch receptor (EYZAGUIRRE and KUFFLER, 1955a, b), vertebrate myelinated nerve (GRAY and RITcHIE, 1954), vertebrate skeletal muscle fibers (IsHIKo and SATO, 1960), and rhesus ape cardiac muscles (KAUFMANN and THEOPHILE, 1967).…”

Section: Discussionmentioning

confidence: 95%

“…Thus, the stretch-induced depolarization and increase in discharge frequency seem to be common phenomenon taking place in various excitable membranes including the pacemaker cell membrane. As to the mechanism of stretchinduced increase in discharge frequency, an increase in Na permeability is likely to be involved in this process (IsHIKo and SATO, 1960;LANGE et al, 1966).…”

Section: Discussionmentioning

confidence: 99%

“…Brooks and his coworkers LANGE et al, 1966) studied the effect of stretch on the discharge rate of in situ or isolated mammalian SA nodal region and suggested that the stretch-induced acceleration of pacemaker activity is mediated by a lowering of membrane potential caused by an increase in Na permeability, while extrinsic nerves are not essential to this reaction.…”

mentioning

confidence: 99%

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Length-dependent changes of pacemaker frequency in the isolated rabbit sinoatrial node.

1984

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To correlate changes in pacemaker frequency with those of length and tension in mammalian atrial tissues, a strip of the sinoatrial (SA) nodal tissue (about 10 mm in length and 4 mm in width) isolated from the rabbit heart was subjected to constant-length and constantload stretches, and the relation between the resulting pacemaker frequency changes and the segmental length changes of the preparation was examined by means of cinematographic recording of the preparation with carbon markers on its surface. The amount of stretch-induced length changes was larger in the perinodal tissue segments than in the SA nodal segments, indicating that the nodal area is less extensible than the perinodal area. The time course of stretch-induced length changes of one nodal segment (closer to the inferior versa cava) was found to roughly parallel that of pacemaker frequency changes, suggesting that the pacemaker frequency is primarily dependent on the length but not on the tension of the SA nodal area.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Length-dependent changes of pacemaker frequency in the isolated rabbit sinoatrial node.

1984

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“…Tachycardia observed in neonatal rabbit atria was not altered by propranolol or by reducing the passive tension, therefore the adrenergic beta mechanism and stretching of S-A nodes (12,13) are not involved. The rate was effectively slowed by acetylcholine (present study) and also by increase in K+, elevation of Ca++ or deprivation of Na+ in bathing media (unpublished data).…”

Section: Discussionmentioning

confidence: 88%