Effect of Stimulation of the Reproductive Organs of the Cow on the Release of an Oxytocin-Like Substance

Hays, R. L.; Vandemark, N. L.

doi:10.1210/endo-52-6-634

Cited by 54 publications

(23 citation statements)

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“…Pituitary is, nevertheless, the main source of circulating OT at this stage of the cycle. Mating may stimulate OT release since milk ejection has been observed in cows during mating [32,33]. Importantly, the marked increase in receptor concentrations is by itself sufficient to initiate responses to low endogenous concentrations of OT also without an increase in plasma OT, since the response is related to the concentration of receptors even at concentrations of free ligand, which are much below the dissociation constant of the receptor [34].…”

Section: Discussionmentioning

confidence: 99%

Oxytocin Receptors in Bovine Cervix: Distribution and Gene Expression during the Estrous Cycle1

Fuchs

Ivell²,

Fields

et al. 1996

Biology of Reproduction

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Oxytocin (OT) receptor (OTR) concentrations were determined in the cervix of nonpregnant cows on cycle Days 0, 3, 7-8, 17, and 19 (n = 3-4 cows each day); [3H]OT was used as the labeled ligand. Mucosal and muscle layers of the cervix were also analyzed separately for both ligand binding and expression of the OTR gene using a newly developed RNase protection assay (RAP). Cellular localization of OTR protein was determined by immunohistochemistry. All regions of cervix from cows at estrus had high concentrations of OTR; in the luteal phase, all were sharply down-regulated. At estrus the mucosal layer had about 30-fold higher concentrations than the muscle layer. OTR mRNA was readily detected by RAP in the mucosa from estrous cows, while much weaker signals were found in the muscle. On Days 7-17, the OTR mRNA signals in both mucosa and muscle were very faint or nondetectable. Thus, there was a good correlation between ligand binding and mRNA expression, which suggests that OTR concentrations are mainly regulated at the transcriptional level. The epithelial cells at the luminal surface of the mucosa were the principal site of immunoreactive OTR; muscle cells showed significantly weaker signals. Previously, OT was found to stimulate prostaglandin (PG) E2 output in vitro in bovine cervical tissues. Since PGE2 is capable of softening the cervix, our findings suggest that OT may have a novel physiological function to cause softening of the bovine cervix mediated by the release of PGE2.

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Section: Discussionmentioning

confidence: 99%

Oxytocin Receptors in Bovine Cervix: Distribution and Gene Expression during the Estrous Cycle1

Fuchs

Ivell²,

Fields

et al. 1996

Biology of Reproduction

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“…Authors do not generally differentiate between an active or passive receptivity with the exception of Benedek & Rubinstein (1942), who did so on the basis of unconscious dream material provided by patients under psycho-analysis. The most striking com¬ parison with the human situation is the fact that although there is a 'hyperresponsivity' of the uterus in oestrous cows, the uterine response in post-oestrous cows still appears after ejaculation (Hays & VanDemark, 1953). Rodolfo (1934) also noted the lack of need for 'heat' to induce the boar to ejaculate into the sow.…”

Section: Hormonal Changesmentioning

confidence: 99%

A Comparative Study of Coital Physiology, With Special Reference to the Sexual Climax

Fox¹,

Fox²

1971

Reproduction

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This review attempts a critical evaluation of experiments dealing with the process of coitus, and highlights the features which are common to many mammalian copulations. Data for blood pressure changes in the dog and bitch during coitus have been re-analysed and compared with findings for the human. Four criteria for orgasm are suggested, and these are traced through the mammalian kingdom for possible similarities. The question of female climax is discussed and its temporal and qualitative aspects are outlined in relation to the male climax.

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“…Corpora lutea from heifers treated with oxytocin have fewer functional luteal cells and an abundance of connective tissue elements, and their progestin con¬ tent is low Staples, McEntee & Hansel, 1961 (Hays & VanDemark, 1953 Armstrong & Hansel (1958). In their experiments, epinephrine in¬ hibited the release of L.H.…”

Section: Introductionmentioning

confidence: 99%

Effect of Oxytocin, Epinephrine and Atropine on the Oestrous Cycle of the Cow

Black¹,

Duby²

1965

Reproduction

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Effect of Stimulation of the Reproductive Organs of the Cow on the Release of an Oxytocin-Like Substance

Cited by 54 publications

References 0 publications

Oxytocin Receptors in Bovine Cervix: Distribution and Gene Expression during the Estrous Cycle1

Oxytocin Receptors in Bovine Cervix: Distribution and Gene Expression during the Estrous Cycle1

A Comparative Study of Coital Physiology, With Special Reference to the Sexual Climax

Effect of Oxytocin, Epinephrine and Atropine on the Oestrous Cycle of the Cow

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