Effect of Oxytocin, Epinephrine and Atropine on the Oestrous Cycle of the Cow

Black, D. L.; Duby, R.T.

doi:10.1530/jrf.0.0090003

Cited by 16 publications

(10 citation statements)

References 10 publications

(10 reference statements)

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“…We believe, however, that our results do demonstrate a physiological phenomenon because there is a strong precedent for oxytocin as a luteolytic agent in mammals (Armstrong & Hansel, 1959 ;Milne, 1963 ;Black & Duby, 1965 ;Auletta et al, 1972a ;Cooke & Knifton, 1981 ). Oxytocin is released selectively into the ovarian venous effluent on the corpus luteum side in sheep after systemic administration of a potent PGF-2oc analogue (Flint & Sheldrick, 1982), PGF-2a is probably the uterine luteolysin in sub-primate mammals (Horton & Poyser, 1976 Khan-Dawood & Dawood, 1983) and monkeys (Khan-Dawood et al, 1984).…”

Section: Resultsmentioning

confidence: 51%

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Oxytocin is luteolytic in the rhesus monkey (Macaca mulatta)

Auletta¹,

Paradis²,

Wesley³

et al. 1984

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Summary. Oxytocin (10 mi.u./\g=m\1/h) or vehicle (0\m=.\5% chlorobutanol in saline, 1 \g=m\1/h) was chronically infused directly into the corpus luteum of normally cyclic rhesus monkeys, by means of an Alzet pump\p=n-\ovarian cannula system. Infusion of oxytocin (N = 6) or vehicle (N = 5) began 6 days after the preovulatory oestradiol surge, and daily peripheral blood samples were taken. Oxytocin caused a significant (P < 0\m=.\05) decrease in progesterone, beginning 1 day after treatment, and oestradiol after 4 days; progesterone and oestradiol remained significantly depressed until menstruation. However, peripheral LH concentrations remained unchanged. The duration of the luteal phase, menstrual cycle and the onset of menses from the initiation of oxytocin infusion were significantly (P < 0\m=.\01) shorter when compared to those of vehicle\x=req-\ treated controls. These results show that oxytocin can induce functional luteolysis in the primate and supports the hypothesis that oxytocin of luteal origin may play a role in spontaneous luteolysis.

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Section: Resultsmentioning

confidence: 51%

“…Exogenously administered oxytocin has been shown to induce premature luteal regression in several domestic animals (Armstrong & Hansel, 1959;Milne, 1963;Black & Duby, 1965;Auletta, Currie & Black, 1972a;Cooke & Knifton, 1981). The neurohypophysial hormones, oxytocin and vasopressin, have been isolated from the human corpus luteum .…”

Section: Introductionmentioning

confidence: 99%

Oxytocin is luteolytic in the rhesus monkey (Macaca mulatta)

Auletta¹,

Paradis²,

Wesley³

et al. 1984

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“…Exogenously administered OT has, however, been shown to induce some degree of luteal regression or insufficiency in several ruminants (222)(223)(224)(225)(226)(227)(228), a process requiring the presence of the uterus (229,230). Although these effects were originally considered pharmacological, several new studies suggest that OT may have a physiological role during luteolysis in ruminants.…”

Section: Oxytocin (Ot) and Luteolysis: Sheep And Cowsmentioning

confidence: 99%

Mechanisms Controlling Corpus Luteum Function in Sheep, Cows, Nonhuman Primates, and Women Especially in Relation to the Time of Luteolysis

Auletta

Flint²

1988

Endocrine Reviews

164

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“…Daily administration of oxytocin to heifers during the first week after oestrus markedly shortens the ensuing dioestrus, and the subsequent oestrus occurs 8-12 days, instead of the usual 21 days, after the preceding oestrus (Armstrong & Hansel, 1959;Anderson & Bowerman, 1963;Anderson, Bowerman & Melampy, 1965 ;Black & Duby, 1965). Premature oestrus is also induced when oxytocin is administered on Days 3 to 6 (Hansel & Wagner, 1960;Black & Duby, 1965;Auletta, Currie & Black, 1972) or Days 3 to 7 after oestrus (Harms & Malven, 1969).…”

Section: Introductionmentioning

confidence: 99%

“…Premature oestrus is also induced when oxytocin is administered on Days 3 to 6 (Hansel & Wagner, 1960;Black & Duby, 1965;Auletta, Currie & Black, 1972) or Days 3 to 7 after oestrus (Harms & Malven, 1969). Armstrong & Hansel (1959) found that oxytocin was ineffective in hysterectomized heifers, but induced precocious oestrus in shamoperated animals.…”

Section: Introductionmentioning

confidence: 99%

The effect of oxytocin treatment on the levels of prostaglandin F in the blood of heifers

Newcomb¹,

Booth²,

Rowson³

1977

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Six heifers with normal oestrous cycles were treated i.m. with 100 i.u. oxytocin on 3 consecutive days, commencing on Days 1-6 after oestrus, and the levels of prostaglandin (PG) F in posterior vena cava plasma were compared with pretreatment values. An increase of PGF in response to oxytocin was significantly influenced by day, with the greatest response occurring on Day 3 after oestrus. In an ovariectomized heifer the levels of PGF in posterior vena cava plasma increased 24 h after priming with oestradiol, but no further increase occurred after oxytocin injection. Peak levels of PGF were higher in the plasma of the posterior vena cava than in the jugular vein. Various storage conditions of the blood before centrifugation and freezing (--20 degrees C) produced significant differences in plasma levels of endogenous PGF, but storage experiments with added labelled PGF-2alpha indicated that the PG was stable in plasma and whole blood.

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Effect of Oxytocin, Epinephrine and Atropine on the Oestrous Cycle of the Cow

Cited by 16 publications

References 10 publications

Oxytocin is luteolytic in the rhesus monkey (Macaca mulatta)

Oxytocin is luteolytic in the rhesus monkey (Macaca mulatta)

Mechanisms Controlling Corpus Luteum Function in Sheep, Cows, Nonhuman Primates, and Women Especially in Relation to the Time of Luteolysis

The effect of oxytocin treatment on the levels of prostaglandin F in the blood of heifers

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