Effect of Stimulation of Neurotransmitter Systems on Heart Rate Variability and β-Adrenergic Responsiveness of Erythrocytes in Outbred Rats

Kur’yanova, E. V.; Tryasuchev, A. V.; Stupin, V. O.; Teplyi, D. L.

doi:10.1007/s10517-017-3731-0

Cited by 5 publications

(1 citation statement)

References 8 publications

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“…It has been hypothesized that interventions that increase HRV may be protective against cardiac mortality and sudden cardiac death. These interventions consist of beta adrenergic blockade, antiarrhythmic drugs, muscarinic receptor blockers, thrombolysis, and physical activity (Kur'yanova, Tryasuchev, Stupin, & Teplyi, 2017Larosa et al, 2005). Amongst these, regular physical training might contribute to cardiac health by modulating the autonomic functions.…”

Section: Introductionmentioning

confidence: 99%

How Do Different Types of Physical Activity Affect Cardiac Functions in Children?

Pektas¹,

Pektaş²

2021

ERISS

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This study aims to investigate how different types of regular physical activity affect cardiac functions in school children. This is a cross-sectional review of 15 children who are not engaged with any regular physical activity (controls) and 60 athletes who swim (n=15), play basketball (n=15), play volleyball (n=15), and play tennis (n=15) regularly. The mean age of the control children was computed as 11.3±1.8 years whereas the mean ages of swimmer children, the children who play basketball, volleyball and tennis regularly were calculated as 10.7±1.5 years, 12.0±1.9 years, 12.6±2.2 years and 10.6±1.4 years respectively. The children who are not engaged with any sports, the children who swim, and the children who play basketball, volleyball, and tennis are statistically similar with respect to age, sex, height, weight, and body mass index (p>0.05 for all). When compared to the controls and other athletes, the swimmer children have significantly higher left ventricle diastolic mass, higher left ventricle posterior wall systolic thickness, lower mitral A wave, higher mitral annular plane systolic excursion, and higher mitral E/A ratio (p=0.006, p=0.035, p=0.030, p=0.025 and p=0.043 respectively). The swimmer children have significantly lower interventricular septum E and A waves and significantly longer left ventricle isovolumic relaxation time than the controls and other athletes (p=0.001, p=0.040 and p=0.004 respectively). When compared with the controls and other athletes, the swimmer children have significantly lower p-wave dispersion and QT dispersion values (p=0.038 and p=0.035 respectively). The swimmer children have significantly higher total power and SDNN values than the controls and other athletes (p=0.046 and p=0.026 respectively). Swimming might contribute to the growth of cardiac muscles and help to improve the cardiac conduction system and enhance parasympathetic innervation of the heart in children.

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Section: Introductionmentioning

confidence: 99%

How Do Different Types of Physical Activity Affect Cardiac Functions in Children?

Pektas¹,

Pektaş²

2021

ERISS

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Effect of Atropine on Adrenergic Responsiveness of Erythrocyte and Heart Rhythm Variability in Outbred Rats with Stimulation of the Central Neurotransmitter Systems

et al. 2018

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Single injection of muscarinic cholinoceptor blocker atropine (1 mg/kg) to outbred male rats reduced β-adrenergic responsiveness of erythrocytes (by 2.2 times) and the content of epinephrine granules on erythrocytes (by 1.5 times), significantly increased HR and rigidity of the heart rhythm, and manifold decreased the power of all spectral components of heart rhythm variability. Stimulation of the central neurotransmitter systems increased β-adrenergic responsiveness of erythrocytes (by 15-26%), decreased the number of epinephrine granules on erythrocytes (by 25-40%), and increased HR and cardiac rhythm intensity. These changes were most pronounced after stimulation of the serotoninergic system. Administration of atropine against the background of activation of central neurotransmitter systems did not decrease β-adrenergic responsiveness of erythrocytes (this parameter remained at a stably high level and even increased during stimulation of the dopaminergic system), but decreased the number of epinephrine granules on erythrocytes, increased HR, and dramatically decreased the power of all components of heart rhythm variability spectrum. The response to atropine was maximum against the background of noradrenergic system activation and less pronounced during stimulation of the serotoninergic system. Thus, substances that are complementary to cholinergic receptors modulated adrenergic effect on the properties of red blood cells, which, in turn, can modulate the adrenergic influences on the heart rhythm via the humoral channel of regulation. Stimulation of central neurotransmitter systems that potentiates the growth of visceral adrenergic responsiveness weakens the cholinergic modulation of the adrenergic influences, especially with respect to erythrocyte responsiveness. Hence, changes in the neurotransmitter metabolism in the body can lead to coupled modulation of reception and reactivity to adrenergic- and choline-like regulatory factors at the level of erythrocyte membranes, which can be important for regulation of heart rhythm.

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Effects of Blockage of Peripheral Choline, Serotonin, and Dopamine Receptors on Heart Rhythm Variability in Rats under Conditions of Stimulation of Neurotransmitter Systems

et al. 2019

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Effect of Stimulation of Neurotransmitter Systems on Heart Rate Variability and β-Adrenergic Responsiveness of Erythrocytes in Outbred Rats

Cited by 5 publications

References 8 publications

How Do Different Types of Physical Activity Affect Cardiac Functions in Children?

How Do Different Types of Physical Activity Affect Cardiac Functions in Children?

Effect of Atropine on Adrenergic Responsiveness of Erythrocyte and Heart Rhythm Variability in Outbred Rats with Stimulation of the Central Neurotransmitter Systems

Effects of Blockage of Peripheral Choline, Serotonin, and Dopamine Receptors on Heart Rhythm Variability in Rats under Conditions of Stimulation of Neurotransmitter Systems

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