Effect of Stent Placement, Balloon or Cutting Balloon Dilatation on Stricture Formation after Caustic Esophageal Burn in Rats

Kapısız, Alparslan; Karabulut, Ramazan; Sönmez, Kaan; Türkyılmaz, Zafer; Poyraz, Aylar; Gülbahar, Özlem; Önal, Baran; Ozbayoglu, Asli; Başaklar, A. Can

doi:10.1055/s-0031-1275700

Cited by 6 publications

(4 citation statements)

References 15 publications

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“…Furthermore, studies conducted on small animals, such as mice, used immunodeficient animals, and did not allow for stent deployment with an endoscope (14,17,21,22). Therefore, in present study rabbits were selected as an animal model, as they are sufficiently large to allow for the oral insertion of an ultra-slim endoscope and stent introducer set (25,26). …”

Section: Discussionmentioning

confidence: 99%

Effect of a paclitaxel-eluting metallic stent on rabbit esophagus

Yin¹,

Gao²,

Chen³

et al. 2016

Experimental and Therapeutic Medicine

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The use of self-expanding metallic stents (SEMS) is the current treatment of choice for malignant gastrointestinal obstructions. A paclitaxel-eluting metallic SEMS (PEMS) may have an antitumor effect on esophageal tissue. PEMS with 10% paclitaxel or conventional SEMS were inserted into the lower esophagus of rabbits. Following the insertion of the stents for 1, 2, 4 and 6 weeks, the rabbits were sacrificed and the status of the stent insertion was examined, as well as any macroscopic or microscopic mucosal changes in the esophageal tissue. All the rabbits survived until death without any complications. No migration following stent insertion occurred. The number of cases with proximal obstruction increased in a time-dependent manner, and no significant difference was observed between the two groups. Gross histological examination showed similar tissue reaction to the stents at 1, 2 and 4 weeks, and inflammatory cell infiltrating was higher in the SEMS group at 1 and 2 weeks. However, inflammatory cell infiltration was markedly higher in the PEMS group at 4 and 6 weeks. Food-intake and weight were similar in the two groups. The results of the present study demonstrated that PEMS may serve as a safe alternative treatment strategy for esophageal obstruction. Furthermore, PEMS may inhibit the tumor growth of the esophageal wall through inflammatory infiltration and targeted drug delivery. A tumor model will be required in the future for evaluating the prognosis of patients with advanced esophageal carcinoma.

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Section: Discussionmentioning

confidence: 99%

Effect of a paclitaxel-eluting metallic stent on rabbit esophagus

Yin¹,

Gao²,

Chen³

et al. 2016

Experimental and Therapeutic Medicine

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show abstract

“…The fact that the thickness of the esophageal wall in both groups has remained constant, while the luminal diameter has not, supports the hypothesis that the device does not increase tissue damage and allows the preservation of the intraluminal space. This tube's protective effect against stricture formation could be explained by the reduction of potential inflammation, and fibroblast collagen secretion, which improved the organization into fine bundles, allowing reparation with less formation of scar tissue [27,28]. These findings will need to be confirmed in children with caustic burns of the esophagus, who are ultimately the main beneficiaries of this translational research.…”

Section: Discussionmentioning

confidence: 98%

Protective effect of early placement of nasogastric tube with solid dilator on tissue damage and stricture formation after caustic esophageal burns in rabbits

Defagó

Moyano

Bernhardt

et al. 2015

Journal of Pediatric Surgery

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“…Thus, they were only used to assess the safety of stenting [21-23]. Furthermore, small animal models, such as mice, were immunodeficient and may potentially exhibit malignant esophagostenosis, this, could be used to study the efficiency and mechanism of stenting; however, these small animal models can not allow for stenting, according to the procedures designed for humans [24-26]. Thus, they are unsuitable and are seldom used for studies on stents.…”

Section: Discussionmentioning

confidence: 99%

Establishing a rabbit model of malignant esophagostenosis using the endoscopic implantation technique for studies on stent innovation

et al. 2014

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BackgroundStents are recommended in patients with dysphagia caused by esophageal stricture, but an ideal stent does not currently exist. Thus, studies on new esophageal stents are necessary, and suitable animal models are desperately needed for these studies. The aim of this study was to establish a model of malignant esophageal stricture in rabbit for studies on stent innovation.MethodsA total of 38 New Zealand white rabbits were used in this study. Using the endoscopic submucosal injection technique, VX2 fragments were inoculated into the submucosal layer of the rabbit thoracic esophagus, and an endoscopic follow-up was subsequently performed to observe the tumor development and progression. The self-expandable metal stents were randomly deployed in rabbits with severe esophageal stricture to investigate the safety and feasibility of the animal models for stenting.ResultsAn endoscopic implantation procedure for VX2 tumors was completed in 34/38 rabbits, and tumor development was confirmed in 30/34 animals. The success rate of the endoscopic implantation and tumor development were 89.4% (95% CI, 79.6% to 99.2%) and 88.2% (95% CI, 76.9% to 99.5%) respectively. During the endoscopic follow-up period, severe esophageal stricture occurred in 22/30 rabbits with a rate of 73.3% (95% CI, 57.5% to 89.1%), and 12/22 models received stent placement. During and after stent implantation, no severe stent-related complication or mortality occurred in the animal models. The rabbits that received stent placement survived longer than those without stent implantation (the mean survival time: 53.9 days versus 40.3 days, P = 0.016).ConclusionThe endoscopic method is a safe and effective method for establishing a malignant esophagostenosis model in rabbits. This model can simulate the human body environment for stent deployment and is an excellent tool for the study of stent innovation for the treatment of esophageal cancer.

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Effect of Stent Placement, Balloon or Cutting Balloon Dilatation on Stricture Formation after Caustic Esophageal Burn in Rats

Abstract: Stenting performed at the time of corrosive injury and cutting balloon dilatation performed after stricture formation had a positive effect with regard to SI and weight gain in an animal model.

Cited by 6 publications

References 15 publications

Effect of a paclitaxel-eluting metallic stent on rabbit esophagus

Effect of a paclitaxel-eluting metallic stent on rabbit esophagus

Protective effect of early placement of nasogastric tube with solid dilator on tissue damage and stricture formation after caustic esophageal burns in rabbits

Establishing a rabbit model of malignant esophagostenosis using the endoscopic implantation technique for studies on stent innovation

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