Effect of static magnetic field on cell migration

Abstract

SUMMARYThe effect of a magnetic field on cells has long been investigated, but there are few quantitative investigations of the migration of cells. Cell migration is important as one of the fundamental activities of the cell. This study proposes a method to evaluate quantitatively the cell diffusion constant and the effect of a static magnetic field on cell migration. The cell lines are neuroblastoma (NG108-15), fibroblastoma (NIH/3T3), and osteoblastoma (MC3T3-E1). The static magnetic field of 30 or 120 mT is impressed by a permanent magnet in a vertical or horizontal direction to the dish. It is shown that the cell diffusion constant can represent the cell migration as the cell activity. It is found that the cell migration is enhanced by exposure to the magnetic field, depending on the kind of cell. It is conjectured that the static magnetic field affects cell migration, which is downstream of the information transmission.

Static magnetic field regulates proliferation, migration, differentiation and YAP/TAZ activation of human dental pulp stem cells

“…Migration induced by SMF depends on the different cell types. Cell migration was enhanced by 30 and 120 mT of SMF in neuroblastoma and fibroblastoma (Hashimoto, Kawasumi, & Saito, ). In contrast, 5 mT of SMF inhibited the migration of human vascular smooth muscle cells (Li et al, ).…”

Use of 0.4‐Tesla static magnetic field to promote reparative dentine formation of dental pulp stem cells through activation of p38 MAPK signalling pathway

“…Hashimoto et al . () used SMF to stimulate the migration of various types of cells and found that the migration behaviour was significantly enhanced for high‐activity cells, such as neuroblastoma and fibroblastoma. The present study has similarly found that 0.4‐T SMF promotes the migration of DPSCs towards the injured site (scratch wound) (Fig.…”

“…Hashimoto et al . () reported that SMFs stimulate the migration of certain cell types. A growing body of evidence suggests that the p38 MAPK signalling pathway plays a fundamental role in cell proliferation, cell migration and odontogenesis (Vandomme et al .…”

Cellular Perception: When the Cell Model Includes a Sense Order which Ensues from a Philosophy of Nature, the Signaling and Epigenetics Effects which Can Result from Exposure to Magnetic Fields Are Described Better

“…transmission of significant information, indicated Hashimoto, (2007, [79]). Wang, (2009, [34]), showed that the exposure of embryonic cells to SMF modulates genes expressions of more than nine signaling networks associated to the inflammatory cytokine IL-6.…”